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Gami B.,Ipcowala Santram Institute of Biotechnology and Emerging science | Parabia F.,Ashok And Rita Patel Ins Of Integrated Study And Research In Biotechnology And Allied Science Aribas
International Journal of Pharmacy and Technology | Year: 2011

Increased resistance against Plasmodium falciparum in the present drugs is an impetus for dynamic study filed for new antimalarial agent from plants & chemically synthesized molecule. In present attempt, acetone extract of Alstonia scholaris, Moringa oleifera, and Tinospora cordifolia, was tested for schizonticidal activity of Plasmodium falciparum. The 50 % inhibitory concentration (IC50) value range from 0.08 μM to 0.26μM. Components of acetone fraction were separated by high performance thin layer chromatography (HPTLC) and scanned at 366 nm. All plants showed strong schizonticidal activity. All the three plant extracts by further purification could be use as an effective, alternative source of herbal anti-malarial drugs.

Gami B.,Ipcowala Santram Institute of Biotechnology and Emerging science | Pathak S.,Veer Narmad South Gujarat University | Parabia M.,Veer Narmad South Gujarat University
Asian Pacific Journal of Tropical Biomedicine | Year: 2012

Mimusops elengi is Indian native plant and is used for a long time in the history of the medicine. Plant was well studied in majority of the world because of its high potential medicinal value. Traditionally all different part of this plant, namely leaf, root, fruit, seed, bark and flower are used to cure various kinds of disorders. Information compiled here will be useful to improve the present investigation of several health care research regarding the Mimusops elengi. © 2012 Asian Pacific Tropical Biomedical Magazine.

Gami B.,Ipcowala Santram Institute of Biotechnology and Emerging science | Kothari I.L.,Ipcowala Santram Institute of Biotechnology and Emerging science
International Journal of Pharma and Bio Sciences | Year: 2011

Since ancient time, Phyllunthus niruri L. are using in many herbal preparations. Increasing demand of P. niruri lead to adulteration, and thus there is a global need to develop quality plant material. In present investigation, an efficient in vitro technology was developed for a rapid and large-scale production of P. niruri via axillary bud proliferation using nodal segments of the mature plants. Elongated shoots were cultured on half strength MS medium fortified with various auxins such as NAA, 2, 4-D, IBA, IAA and at different concentrations (0.5 - 5.0 mg/l). In vitro developed plantlets were harden and acclimatized in natural environment. The antimicrobial activity (by well diffusion method) and antioxidant activity (by DPPH scavenging assay, reducing power and total antioxidant capacity methods) of in vitro developed plant, naturally grown plant and commercial available sample of P.niruri were determined. Results of antimicrobial activity of methanol extract from in vitro cultured P.niruri showed great potential as source of antimicrobial agent. In DPPH scavenging assay IC50 value of the three extracts was found 49.24μg/ml (in vitro), 41.66μg/ml (in vivo) and 36.14μg/ml (market sample) while the IC50 value of the reference standard ascorbic acid was 53.89 μg/ml. Results suggest in vitro developed plant posses highest antimicrobial and antioxidant activity and thus developed in vitro cultivation technology would provide quality plant material for medicine.

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