Iovel Kutateladze Institute of Pharmacochemistry

Tbilisi, Georgia

Iovel Kutateladze Institute of Pharmacochemistry

Tbilisi, Georgia

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Skhirtladze A.,Iovel Kutateladze Institute of Pharmacochemistry | Kemertelidze E.,Iovel Kutateladze Institute of Pharmacochemistry | Nebieridze V.,Iovel Kutateladze Institute of Pharmacochemistry | Ganzera M.,University of Innsbruck
Helvetica Chimica Acta | Year: 2016

Three new phenylethanoid glycosides, named digicilisides A - C (1 - 3, resp.), have been isolated from the roots of Digitalis ciliata, along with five known phenylethanoid glycosides. The structures of 1 - 3 were identified as 2-(4-hydroxy-3-methoxyphenyl)ethyl β-d-glucopyranosyl-(1→3)-[α-l-rhamnopyranosyl-(1→6)]-4-O-[(E)-feruloyl]-β-d-glucopyranoside (1), 2-(3,4-dihydroxyphenyl)ethyl α-l-arabinopyranosyl-(1→2)-[β-d-glucopyranosyl-(1→3)]-[α-l-rhamnopyranosyl-(1→6)]-4-O-[(E)-feruloyl]-β-d-glucopyranoside (2), and 2-(3,4-dihydroxyphenyl)ethyl β-d-glucopyranosyl-(1→3)-{6-O-[(E)-feruloyl]-β-d-glucopyranosyl-(1→6)}-4-O-[(E)-caffeoyl]-β-d-glucopyranoside (3). © 2016 Verlag Helvetica Chimica Acta AG, Zürich.


Kemertelidze E.,Iovel Kutateladze Institute of Pharmacochemistry | Skhirtladze A.,Iovel Kutateladze Institute of Pharmacochemistry | Ganzera M.,University of Innsbruck
Helvetica Chimica Acta | Year: 2015

Three new furostanol glycosides, named ciliatasides A, B, and C (1-3, resp.), have been isolated from the roots of Digitalis ciliata, along with two known furostanol glycosides. The structures of the new compounds were identified as (2α,3β,5α,14β,25R)-26-(β-D-glucopyranosyloxy)-2-hydroxyfurost-20(22)-en-3-yl β-D-glucopyranosyl-(1→2)-[β-D-glucopyranosyl-(1→3)]-β-D-galactopyranoside (1), (2α,3β,5α,14β,22R)-26-(β-D-glucopyranosyloxy)-2-hydroxy-22-methoxyfurost-25(27)-en-3-yl β-D-galac-topyranosyl-(1→2)-[β-D-xylopyranosyl-(1→3)]-β-D-glucopyranosyl-(1→4)-β-D-galactopyranoside (2), and (2α,3β,5α,14β,22R, 25R)-26-(β-D-glucopyranosyloxy)-2,22-dihydroxyfurostan-3-yl β-D-glucopyrano-syl-(1 → 2)-[β-D-glucopyranosyl-(1→3)]-β-D-galactopyranoside (3). © 2015 Verlag Helvetica Chimica Acta AG, Zürich.


Skhirtladze A.,Iovel Kutateladze Institute of Pharmacochemistry | Perrone A.,University of Salerno | Montoro P.,University of Salerno | Benidze M.,Iovel Kutateladze Institute of Pharmacochemistry | And 3 more authors.
Phytochemistry | Year: 2011

The occurrence of steroidal saponins in the rhizomes of Yucca gloriosa has been detected by LC-MS. On the basis of the LC-MS analysis, five steroidal glycosides, including three spirostane, one furostane and one cholestane glycosides, along with seven known compounds have been isolated and characterized by ESI-MS and by the extensive use of 1D- and 2D-NMR experiments. Quantitative analysis of the steroidal glycosides in Y. gloriosa rhizomes was performed by an LC-MS method validated according to European Medicines Agency (EMEA) guidelines. The dried BuOH extract obtained from rhizomes contains more than 25% w/w of glycosides, thus Y. gloriosa rhizomes can be considered a rich source of steroidal glycosides. © 2010 Elsevier Ltd. All rights reserved.


Meskheli M.,Tbilisi State Medical University | Bakuridze A.,Tbilisi State Medical University | Vachnadze V.,Iovel Kutateladze Institute of Pharmacochemistry
ICBEE 2010 - 2010 2nd International Conference on Chemical, Biological and Environmental Engineering, Proceedings | Year: 2010

Alkaloids are the natural compounds which mostly contain basic nitrogen atoms. They are characterized by multilateral pharmacological activity, broad spectrum of therapeutic action and hypo toxicity. Receipt of herbal alkaloids is difficult technological process connected with heavy financial expenses. Together with it, there are used organic solvents polluting environment and finished product. The purpose of our research was to develop of alternative and safe technologies of herbal alkaloids receipt. Extraction of alkaloids from medicinal herbal raw material was realized by two methods: with organic solvent and with diluents gas - recirculation of the latter in closed system. The results were justified by HPLC method. © 2010 IEEE.


PubMed | Iovel Kutateladze Institute of Pharmacochemistry
Type: Journal Article | Journal: Phytochemistry | Year: 2010

The occurrence of steroidal saponins in the rhizomes of Yucca gloriosa has been detected by LC-MS. On the basis of the LC-MS analysis, five steroidal glycosides, including three spirostane, one furostane and one cholestane glycosides, along with seven known compounds have been isolated and characterized by ESI-MS and by the extensive use of 1D- and 2D-NMR experiments. Quantitative analysis of the steroidal glycosides in Y. gloriosa rhizomes was performed by an LC-MS method validated according to European Medicines Agency (EMEA) guidelines. The dried BuOH extract obtained from rhizomes contains more than 25% w/w of glycosides, thus Y. gloriosa rhizomes can be considered a rich source of steroidal glycosides.

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