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Vlad C.,Ion Chiricuta Institute of Oncology Cluj Napoca | Kubelac P.,University of Medicine and Pharmacy, Cluj-Napoca | Fetica B.,Ion Chiricuta Institute of Oncology Cluj Napoca | Vlad D.,University of Medicine and Pharmacy, Cluj-Napoca | And 2 more authors.
Journal of B.U.ON. | Year: 2015

Purpose: The evaluation ofCD3+ T-cell density is believed to have a higher prognostic value than the conventionally used TMN stage in colorectal cancer (CRC), but the role of regulatory T lymphocytes (Treg) is still debated. Our study determined the prognostic value offorkhead box P3 nuclear transcription factor (F0XP3) positive Treg and CD3+ T-cells in the invasive margin of CRC compared with other known prognostic factors. Methods: The prognostic factors analysed in 42 pa-tients with CRC stage II (N=13) and III (N=29), were age, tumor location, TNM stage, histological grade, vascular, lymphatic and perineural invasion. CD3+ T-cells and FOXP3∗ Treg density was evaluated by im- munohistochemistry. Results: The median CD3+ T-cells and F0XP3+ Treg density was 438.93/mm2 and 162.25/mm2, respectively. Patients with high F0XP3+ Treg density showed improved 5-year survival rate of 89.41%, compared with 64.6% of those with low density (p=0.024). Conclusions: Increased CD3+ T-cells and F0XP3+ Treg density is associated with improved survival, but only the latter proved to be an independent prognostic factor. FOXP3∗ Treg infiltrate may play an important prognostic role, which, in combination with other predictive factors, could lead to the development of specific treatment regimens. Source


Vlad C.,Ion Chiricuta Institute of Oncology Cluj Napoca | Kubelac P.,University of Medicine and Pharmacy, Cluj-Napoca | Vlad D.,University of Medicine and Pharmacy, Cluj-Napoca | Irimie A.,Ion Chiricuta Institute of Oncology Cluj Napoca | Cadariu P.A.,Ion Chiricuta Institute of Oncology Cluj Napoca
Journal of B.U.ON. | Year: 2015

Purpose: Morphopathological factors continue to be the most important prognostic factors in colorectal cancer, but there is evidence regarding the prognostic value of some factors that are not yet used in current clinical practice. The purpose of the present study was to evaluate the most important clinical, morphopathological and therapeutic prognostic factors in rectal cancer. Methods: This study retrospectively analyzed 317 patients diagnosed and treated at the Ion Chiricuta Institute of Oncology between 2000-2008. The prognostic value of 13 variables was analyzed and correlations between them were established. Nine variables were included in a multivariate analysis model. Results: The 5-year overall survival (OS) was 55.6%, significantly higher for patients with TNM stage I disease (71.7%), compared to stage II (71.4%), stage III (45.4%) and stage IV (12.5%; p<0.001). In multivariate analysis, the independent prognostic factors were tumor stage, age, lymph node invasion, venous, lymphatic and perineural invasion. Conclusions: In addition to the TNM stage and lymph node invasion, age, venous, lymphatic and perineural in-vasion were also proved to have prognostic significance in rectal cancer. Further studies are required for the validation of prognostic assessment models in patients diagnosed with rectal cancer. Source

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