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Baltimore Highlands, MD, United States

Schreiber S.L.,The Broad Institute of MIT and Harvard | Schreiber S.L.,Harvard University | Schreiber S.L.,Howard Hughes Medical Institute | Kotz J.D.,The Broad Institute of MIT and Harvard | And 56 more authors.
Cell | Year: 2015

Small-molecule probes can illuminate biological processes and aid in the assessment of emerging therapeutic targets by perturbing biological systems in a manner distinct from other experimental approaches. Despite the tremendous promise of chemical tools for investigating biology and disease, small-molecule probes were unavailable for most targets and pathways as recently as a decade ago. In 2005, the NIH launched the decade-long Molecular Libraries Program with the intent of innovating in and broadening access to small-molecule science. This Perspective describes how novel small-molecule probes identified through the program are enabling the exploration of biological pathways and therapeutic hypotheses not otherwise testable. These experiences illustrate how small-molecule probes can help bridge the chasm between biological research and the development of medicines but also highlight the need to innovate the science of therapeutic discovery. ©2015 Elsevier Inc.

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