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Friedewald S.M.,Advocate Lutheran General Hospital | Rafferty E.A.,Massachusetts General Hospital | Rose S.L.,Comprehensive Breast Center | Rose S.L.,Solis Womens Health | And 11 more authors.
JAMA - Journal of the American Medical Association | Year: 2014

IMPORTANCE: Mammography plays a key role in early breast cancer detection. Single-institution studies have shown that adding tomosynthesis to mammography increases cancer detection and reduces false-positive results. OBJECTIVE: To determine if mammography combined with tomosynthesis is associated with better performance of breast screening programs in the United States. DESIGN, SETTING, AND PARTICIPANTS: Retrospective analysis of screening performance metrics from 13 academic and nonacademic breast centers using mixed models adjusting for site as a random effect. EXPOSURES: Period 1: digital mammography screening examinations 1 year before tomosynthesis implementation (start dates ranged from March 2010 to October 2011 through the date of tomosynthesis implementation); period 2: digital mammography plus tomosynthesis examinations from initiation of tomosynthesis screening (March 2011 to October 2012) through December 31, 2012. MAIN OUTCOMES AND MEASURES: Recall rate for additional imaging, cancer detection rate, and positive predictive values for recall and for biopsy. RESULTS: A total of 454 850 examinations (n=281 187 digital mammography; n=173 663 digital mammography + tomosynthesis) were evaluated. With digital mammography, 29 726 patients were recalled and 5056 biopsies resulted in cancer diagnosis in 1207 patients (n=815 invasive; n=392 in situ). With digital mammography + tomosynthesis, 15 541 patients were recalled and 3285 biopsies resulted in cancer diagnosis in 950 patients (n=707 invasive; n=243 in situ). Model-adjusted rates per 1000 screens were as follows: for recall rate, 107 (95% CI, 89-124) with digital mammography vs 91 (95% CI, 73-108) with digital mammography + tomosynthesis; difference, -16 (95% CI, -18 to -14; P < .001); for biopsies, 18.1 (95% CI, 15.4-20.8) with digital mammography vs 19.3 (95% CI, 16.6-22.1) with digital mammography + tomosynthesis; difference, 1.3 (95% CI, 0.4-2.1; P = .004); for cancer detection, 4.2 (95% CI, 3.8-4.7) with digital mammography vs 5.4 (95% CI, 4.9-6.0) with digital mammography + tomosynthesis; difference, 1.2 (95% CI, 0.8-1.6; P < .001); and for invasive cancer detection, 2.9 (95% CI, 2.5-3.2) with digital mammography vs 4.1 (95% CI, 3.7-4.5) with digital mammography + tomosynthesis; difference, 1.2 (95% CI, 0.8-1.6; P < .001). The in situ cancer detection rate was 1.4 (95% CI, 1.2-1.6) per 1000 screens with both methods. Adding tomosynthesis was associated with an increase in the positive predictive value for recall from 4.3% to 6.4% (difference, 2.1%; 95% CI, 1.7%-2.5%; P < .001) and for biopsy from 24.2% to 29.2% (difference, 5.0%; 95% CI, 3.0%-7.0%; P < .001). CONCLUSIONS AND RELEVANCE: Addition of tomosynthesis to digital mammography was associated with a decrease in recall rate and an increase in cancer detection rate. Further studies are needed to assess the relationship to clinical outcomes. Copyright 2014 American Medical Association. All rights reserved.

Rehman A.A.,Illinois College | Elmore K.B.,Illinois College | Mattei T.A.,INVISION
Neurosurgical Focus | Year: 2015

Glioblastoma is both the most common and most lethal primary CNS malignancy in adults, accounting for 45.6% of all malignant CNS tumors, with a 5-year survival rate of only 5.0%, despite the utilization of multimodal therapy including resection, chemotherapy, and radiation. Currently available treatment options for glioblastoma often remain limited, offering brief periods of improved survival, but with substantial side effects. As such, improvements in current treatment strategies or, more likely, the implementation of novel strategies altogether are warranted. In this topic review, the authors provide a comprehensive review on the potential of alternating electric fields (AEFs) in the treatment of glioblastoma. Alternating electric fields-also known as tumor-treating fields (TTFs)-represent an entirely original therapeutic modality with preliminary studies suggesting comparable, and at times improved, efficacy to standard chemotherapeutic agents in the treatment of recurrent glioblastoma. A recent multicenter, Phase III, randomized clinical trial comparing NovoTTF-100A monotherapy to physician's best choice chemotherapy in patients with recurrent glioblastoma revealed that AEFs have similar efficacy to standard chemotherapeutic agents with a more favorable side-effects profile and improved quality of life. In particular, AEFs were shown to have limited systemic adverse effects, with the most common side effect being contact dermatitis on the scalp at the sites of transducer placement. This study prompted FDA approval of the NovoTTF-100A system in April 2011 as a standalone therapy for treatment of recurrent glioblastoma refractory to surgical and radiation treatment. In addition to discussing the available clinical evidence regarding the utilization of AEFs in glioblastoma, this article provides essential information regarding the supposed therapeutic mechanism as well as modes of potential tumor resistance to such novel therapy, delineating future perspectives regarding basic science research on the issue. © AANS, 2015.

Mattei T.A.,INVISION | Rehman A.A.,Illinois College
Neurosurgery | Year: 2014

Graphene, a monolayer atomic-scale honeycomb lattice of carbon atoms, has been considered the greatest revolution in metamaterials research in the past 5 years. Its developers were awarded the Nobel Prize in Physics in 2010, and massive funding has been directed to graphene-based experimental research in the last years. For instance, an international scientific collaboration has recently received a &OV0556;1 billion grant from the European Flagship Initiative, the largest amount of financial resources ever granted for a single research project in the history of modern science. Because of graphene's unique optical, thermal, mechanical, electronic, and quantum properties, the incorporation of graphene-based metamaterials to biomedical applications is expected to lead to major technological breakthroughs in the next few decades. Current frontline research in graphene technology includes the development of high-performance, lightweight, and malleable electronic devices, new optical modulators, ultracapacitors, molecular biodevices, organic photovoltaic cells, lithium-ion microbatteries, frequency multipliers, quantum dots, and integrated circuits, just to mention a few. With such advances, graphene technology is expected to significantly impact several areas of neurosurgery, including neuro-oncology, neurointensive care, neuroregeneration research, peripheral nerve surgery, functional neurosurgery, and spine surgery. In this topic review, the authors provide a basic introduction to the main electrophysical properties of graphene. Additionally, future perspectives of ongoing frontline investigations on this new metamaterial are discussed, with special emphasis on those research fields that are expected to most substantially impact experimental and clinical neurosurgery in the near future. ABBREVIATIONS:: BCI, brain-computer interfaceCNS, central nervous systemFRET, fluorescence resonance energy transferGO, graphene oxideMEMS, microelectromechanical systemNEMS, nanoelectromechanical systemNIR, near-infrared region; rGO, reduced graphene oxide © 2014 by the Congress of Neurological Surgeons.

Braga I.L.S.,INVISION | Moraes F.S.,State University of Norte Fluminense
Geophysics | Year: 2013

We have developed and applied an inverse Q filter formulation using the continuous wavelet transform (CWT), which provides a natural domain for time-variant operations, such as compensation for propagation in attenuating and dispersive media. The well-known linear attenuation model, given as a function of time and frequency, was applied very efficiently over wavelet coefficients in the time-frequency domain to correct for amplitude and phase distortions, as necessary. The inverse CWT yields the recovered trace with a broader bandwidth. The process works on a trace-by-trace basis, making no distinction if the data is pre-or poststack. Our motivation was to develop gather conditioning tools to enhance prestack interpretation techniques such as amplitude variation with offset (AVO) analysis and inversion -a technique that is often compromised by tuning and other propagation related issues that degrade seismic resolution. Thus, we investigated the AVO fidelity of our filter and the sensitivity of the results to incorrect values of Q, using real and synthetic data. Our synthetic data experiments clearly showed that AVO anomalies are recovered and preserved in a stable manner, even with values of Q off by 50% of its correct value. The application in time-migrated gathers shows a very natural increase in the vertical definition of the events, especially due to the partial elimination of the tuning effect. The benefits for imaging are also evidenced by comparing stacked sections before and after inverse Q filtering. The higher resolution of seismic sections leads to a better definition of smaller scale stratigraphic and structural features. © 2013 Society of Exploration Geophysicists.

Oliveira S.A.M.,North Fluminense State University | Oliveira S.A.M.,INVISION | Lupinacci W.M.,North Fluminense State University
Geophysical Prospecting | Year: 2013

In order to perform a good pulse compression, the conventional spike deconvolution method requires that the wavelet is stationary. However, this requirement is never reached since the seismic wave always suffers high-frequency attenuation and dispersion as it propagates in real materials. Due to this issue, the data need to pass through some kind of inverse-Q filter. Most methods attempt to correct the attenuation effect by applying greater gains for high-frequency components of the signal. The problem with this procedure is that it generally boosts high-frequency noise. In order to deal with this problem, we present a new inversion method designed to estimate the reflectivity function in attenuating media. The key feature of the proposed method is the use of the least absolute error (L1 norm) to define both the data and model error in the objective functional. The L1 norm is more immune to noise when compared to the usual L2 one, especially when the data are contaminated by discrepant sample values. It also favours sparse reflectivity when used to define the model error in regularization of the inverse problem and also increases the resolution, since an efficient pulse compression is attained. Tests on synthetic and real data demonstrate the efficacy of the method in raising the resolution of the seismic signal without boosting its noise component. © 2013 European Association of Geoscientists & Engineers.

Mattei T.A.,INVISION | Rodriguez A.H.,University of Illinois at Peoria | Sambhara D.,University of Illinois at Peoria | Mendel E.,Ohio State University
Neurosurgical Review | Year: 2014

Neurosurgery is one of the most demanding surgical specialties in terms of precision requirements and surgical field limitations. Recent advancements in robotic technology have generated the possibility of incorporating advanced technological tools to the neurosurgical operating room. Although previous studies have addressed the specific details of new robotic systems, there is very little literature on the strengths and drawbacks of past attempts, currently available platforms and prototypes in development. In this review, the authors present a critical historical analysis of the development of robotic technology in neurosurgery as well as a comprehensive summary of the currently available systems that can be expected to be incorporated to the neurosurgical armamentarium in the near future. Finally, the authors present a critical analysis of the main technical challenges in robotic technology development at the present time (such as the design of improved systems for haptic feedback and the necessity of incorporating intraoperative imaging data) as well as the benefits which robotic technology is expected to bring to specific neurosurgical subspecialties in the near future. © 2014 Springer-Verlag.

Invision | Date: 2014-10-09

Application software; computer software downloaded from the Internet; electronic publications (downloadable); computer software.

News Article | August 25, 2015

Slack is giving other companies a new way to integrate their content into the startup's business chat app. Outside developers can now incorporate a button into their own apps and sites called "Add to Slack." The button lets users of those apps share content or otherwise post in Slack, but without leaving the other apps. Think of it as the Facebook "Like" plugin, but instead of sharing content back to Facebook, you're sharing content into a Slack chat. More than a dozen third-party apps have already added the button to their sites, including Nuzzel, a companion app for Twitter; InVision, a prototyping and design app; and cloud storage service Box. Box's new integration with Slack, for instance, lets Box users import a file from Box or share a link to a file in Slack. InVision's integration means designers can share designs with their team directly to a Slack channel. Slack is also releasing documentation on the new button so that outside developers can incorporate it into their apps. The new function may help Slack keep growing its users at a time when it faces competition in the business collaboration space from established players like Google and Microsoft, as well as from other startups. Over 80 other applications have been already integrated with Slack using its APIs, including Twitter, Google Drive and Dropbox. With the feature announced Tuesday, Slack said it will increase the number of integrations allowed to free users of its app, from five to 10. Users of Slack's paid versions get unlimited external integrations. Slack, which launched in early 2014, claims to have over 1.1 million daily active users. The company says it had roughly 125,000 users a year ago.

News Article | September 17, 2015

Design platform InVision has added another partnership to its mix: Slack. In an effort to “support the entire product design process from start to finish.” InVision is simply adding another tool designers were already using. It also hopes integrating with Slack will lead to more collaboration. InVision has previously teamed up with the likes of Dribbble, Sketch and Box. The company has made use of Slack before, but it was a simple screen sharing workaround. The new Slack integration is similar (you can still share your work directly to Slack), but adds a conversational aspect to your design environment as you’ll now get responses within InVision. That means quicker feedback, which should improve review times and faster project turnarounds.

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