Hemendra G.,Invertis University
Chinese Journal of Chemistry | Year: 2011
A natural proline-rich tetrapeptide cyclo-prolyl-leucyl-prolyl-phenylalanyl was prepared employing solution-phase method of peptide synthesis through coupling of dipeptide fragments Boc-l-Pro-l-Leu-OH and l-Pro-l-Phe-OMe which utilizes diisopropylcarbodiimide (DIPC) as coupling agent and N-methylmorpholine (NMM) as the base. Deprotection of linear tetrapeptide unit followed by its cyclization provided a cyclopeptide, identical in all aspects to the natural molecule. Pharmacological evaluation showed cytotoxic, antifungal and antihelmintic potential of synthesized peptide against Dalton's Lymphoma Ascites (DLA) and Ehrlich's Ascites Carcinoma (EAC) cell lines, pathogenic dermatophytes and earthworms. A natural proline-rich tetrapeptide cyclo-prolyl-leucyl-prolyl-phenylalanyl was prepared employing solution-phase method of peptide synthesis through coupling of dipeptide fragments Boc-l-Pro-l-Leu-OH and l-Pro-l-Phe-OMe which utilizes diisopropylcarbodiimide (DIPC) as coupling agent and N-methylmorpholine (NMM) as the base. Copyright © 2011 SIOC, CAS, Shanghai & WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Gupta A.,Rohilkhand University |
Dubey K.K.,Invertis University
Proceedings of the 2013 3rd IEEE International Advance Computing Conference, IACC 2013 | Year: 2013
This paper introduces a state of art compressor for DNA sequences that makes use of a replacement method. The replacement method introduces words and a word based compression scheme is used for encoding. The encoder uses frequency distribution for assigning the code of words. The designed statistical compression algorithm is efficient and effective for DNA sequence compression. Experiments show that our algorithm is shown to outperform existing compressors on typical DNA sequence datasets. © 2013 IEEE.
Singh V.,Invertis University
Gene | Year: 2014
Synthetic biology is the design and construction of new biological parts, devices and circuits not existing in nature. It provides a novel solution to imminent challenges in a wide variety of fields, including the discovery of new drugs, production chemicals, renewable biofuels, value-added products and cellular reprogramming. Many efforts have been made to design and characterize synthetic genetic parts, including promoter, transcription factors, RBS, degradation tags and transcriptional terminators, among others. These genetic parts have been assembled for construction of a number of synthetic devices and circuits like oscillators, toggle switches, amplifiers and biologic gates; they play a vital role in cell reprogramming for better understanding of cellular mechanisms and control of biological process. They are also useful for the periodic and tunable production of drugs, fine chemicals, vaccines and much more. It is the goal of this review to aid and accelerate future research in synthetic biology. © 2013 Elsevier B.V.
Maurya S.K.,Invertis University |
Tewari M.,Banaras Hindu University |
Sharma B.,Allahabad University |
Shukla H.S.,Banaras Hindu University
Korean Journal of Internal Medicine | Year: 2013
Background/Aims: The higher incidence of gallbladder cancer (GBC) in females has been accredited to the involvement of hormones. The clinical implications of sex hormone receptors in GBC are well established. Cysteine proteases (such as caspase-3-9, etc.) are known to play a central role in the apoptotic pathway. Of these, the downstream enzyme caspase-3 is often activated in the apoptotic path-way. The aim of this work was to examine the status of apoptosis (which directly correlated with the level of active caspase-3) in hormone-responsive GBC. Methods: We used 10 androgen receptor (AR)-positive, 14 estrogen receptor (ER)-positive, 12 HER/neu-positive, eight triple positive, and 10 triple negative malignant GBC human tissue samples. We isolated the total cellular protein from tumor tissues and carried out Western blotting using antipro-caspase-3 and anti-activated caspase-3 antibodies. Results: ER and HER/neu-positive GBC exhibited high caspase-3 activity and low procaspase-3 activity, whereas AR-positive GBC showed no significant level of apoptosis. We also evaluated the apoptosis status of triple positive GBC and triple negative GBC, and found significant apoptosis in triple positive GBC. Conclusions: The results indicate that ER and HER/neu-positive GBCs had active apoptosis, whereas AR-positive GBC was highly resistant to apoptosis. © 2013 The Korean Association of Internal Medicine.
Arora R.,Invertis University |
Mandal U.K.,University of Delhi |
Sharma P.,Jaypee University of Information Technology |
Srivastav A.,Middle East College
Materials Today: Proceedings | Year: 2015
Thermal Properties of Polyaniline (PANI) Composite Film Synthesized by Nanocomposite Material TiO2 and Polyvinyl Alcohol has been investigated by thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), dc conductivity analyses. The results clearly demonstrate that the composite film of nanocomposite material (encapsulated nano-TiO2 and Polyaniline) and poly-vinyl alcohol are more stable at higher temperature than pure polyaniline. © 2015.