Inventiva

Daix, France

Inventiva

Daix, France
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Inventiva (Paris:IVA), société biopharmaceutique spécialisée dans le développement de traitements innovants, notamment contre la fibrose, annonce aujourd’hui les résultats de l’étude toxicologique de 12 mois chez des primates non humains portant sur son principal candidat-médicament, IVA337, un agoniste pan-PPAR actuellement en phase IIb de développement clinique dans la stéatohépatite non alcoolique (NASH) et la sclérodermie systémique. Au cours de la période de traitement et quelle que soit la dose, aucun signe clinique indésirable dont ceux habituellement liés aux thiazolidinediones n’ont été observés. Cette étude toxicologique a été conduite pour répondre aux exigences règlementaires des autorités de santé, dont la FDA et l’EMA. Inventiva mène également actuellement deux études de carcinogénicité de 24 mois chez des rongeurs, et après 18 mois de traitement les deux études se déroulent comme prévu. Lorsque ces études seront terminées, Inventiva disposera alors mi-2018 du dossier toxicologique requis pour initier les études de phase III et demander les autorisations de mise sur le marché. « Ces résultats seront importants pour les discussions de fin de phase IIb que nous aurons avec les autorités réglementaires. Inventiva poursuit ainsi sa stratégie qui consiste à préparer IVA337 pour les études pivots d’enregistrement dans la NASH et la sclérodermie systémique, » commente le Dr Pierre Broqua, Directeur scientifique et cofondateur d’Inventiva. « Nous sommes impressionnés par le profil d’innocuité d’IVA337, qui ne montre pas les effets indésirables habituellement observés avec les thiazolidinediones ou les fibrates, » ajoute le Dr Jeri El-Hage, Toxicologue et Consultant Règlementaire spécialiste du domaine des PPARs au sein de Aclairo Pharmaceutical Development Group. Inventiva conduit actuellement des études cliniques de phase IIb avec IVA337, à la fois dans la NASH et la sclérodermie systémique, pour des résultats attendus au cours du second semestre 2018. Dans les études cliniques antérieures réalisées avec IVA337, le médicament a été bien toléré et a montré une bonne sécurité d’emploi, avec notamment une absence d’effet sur les taux sanguins de créatinine, les paramètres hépatiques, la CPK, la pression artérielle, l’hémodilution ou la prise de poids. Son produit phare, IVA337, est un candidat médicament qui dispose d’un mécanisme d’action unique passant par l’activation de l’ensemble des PPAR (récepteurs activés par les proliférateurs de peroxysomes) alpha, gamma et delta qui jouent un rôle fondamental dans le contrôle du processus fibrotique. Son action anti-fibrotique permet notamment de cibler deux indications à fort besoin médical : la NASH, une pathologie sévère du foie en fort développement et qui touche déjà aux États-Unis plus de 30 millions de personnes, et la sclérodermie systémique, une maladie dont le taux de mortalité est très élevé et sans aucun traitement approuvé à ce jour. Inventiva emploie à ce jour plus de 100 personnes hautement qualifiées et bénéficie d’installations de R&D de pointe achetées au groupe pharmaceutique international Abbott regroupant, près de Dijon, une chimiothèque de plus de 240 000 molécules et des plateformes en biologie, chimie, ADME et pharmacologie. Certaines déclarations figurant dans ce document ne se rapportent pas à des faits historiquement avérés, mais constituent des projections, estimations et autres données à caractère prévisionnel basées sur l’opinion des dirigeants. Ces déclarations traduisent les opinions et hypothèses qui ont été retenues à la date à laquelle elles ont été faites. Elles sont sujettes à des risques et incertitudes connus et inconnus à raison desquels les résultats futurs, la performance ou les événements à venir peuvent significativement différer de ceux qui sont indiqués ou induits dans ces déclarations.


News Article | May 15, 2017
Site: www.businesswire.com

Inventiva (Paris:IVA), a biopharmaceutical company developing innovative therapies, particularly to treat fibrosis, announced today the results of a 12 month non-human primate toxicology study with its lead drug candidate IVA337, a pan PPAR agonist in phase IIb clinical development in non-alcoholic steato-hepatitis (NASH) and systemic sclerosis (SSc). No adverse clinical signs were observed during the treatment period at any dose-level and none of the typical adverse effects related to the thiazolidinones were observed. This toxicology study was conducted to meet the regulatory requirements of health authorities including the FDA and EMA. Inventiva is also advancing with two carcinogenity studies of 24 month duration in rodents, and after 18 months of treatment both studies are progressing as planned. Once these are completed, Inventiva will have by mid-2018 the necessary toxicology package required to move into Phase III testing and for regulatory filing. “These results will be important for the end of phase IIb discussions with regulatory authorities. Inventiva continues to deliver on its strategy to have IVA337 ready to enter into pivotal trials in NASH and SSc,” said Dr. Pierre Broqua, Chief Scientific Officer and Cofounder of Inventiva. “We are impressed by the benign profile of IVA337, which does not show the side effects typically observed with thiazolidinediones or fibrates” added Dr. Jeri El-Hage, Toxicologist and Regulatory Consultant, expert in the PPAR field at Aclairo Pharmaceutical Development Group. The objective of this study was to evaluate the safety profile of IVA337 following daily oral administration to cynomolgus monkeys over 52 weeks. Forty eight monkeys received a daily oral administration of IVA337 at doses of 100, 250 or 625 mg/kg/day or placebo for 52 weeks. On completion of the treatment period, designated animals were held for a 6-week treatment-free period in order to evaluate the reversibility of any findings. Inventiva is currently conducting Phase IIb clinical trials with IVA337 in both NASH and SSc, and results are expected in the second half of 2018. In previous clinical studies with IVA337, the drug was well tolerated and safe, in particular there were no changes of creatinine blood levels, liver function tests, CPK, blood pressure, no signal of haemodilution or weight gain. Inventiva is a biopharmaceutical company specialized in the development of drugs interacting with nuclear receptors, transcription factors and epigenetic modulators. Inventiva’s research engine opens up novel breakthrough therapies against fibrotic diseases, cancers and orphan diseases with substantial unmet medical needs. IVA337, its lead product, is an anti-fibrotic treatment with a strong action mechanism permitting the activation of all three alpha, gamma and delta PPARs (peroxisome proliferator-activated receptors), which play key roles in controlling the fibrotic process. Its anti-fibrotic action targets two initial indications with substantial unmet medical need: NASH, a severe and increasingly prevalent liver disease already affecting over 30 million people in the United States, and systemic sclerosis, a disease with a very high mortality rate and for which there is no approved treatment to date. Inventiva is also developing in parallel, a second clinical product, IVA336, which is a treatment for three different forms of mucopolysaccharidosis: MPS I or Hurler-Scheie syndrome, MPS II or Hunter syndrome and MPS VI also known as Maroteaux-Lamy syndrome. Inventiva has a preclinical stage oncology portfolio. Inventiva benefits from partnerships with world-leading research entities such as the Institut Curie. Two strategic commercial partnerships, one of which is at clinical stage, have also been developed with AbbVie and Boehringer Ingelheim, making Inventiva eligible for preclinical, clinical, regulatory and commercial milestone payments, in addition to royalties on the products resulting from the partnerships. Inventiva employs over 100 highly qualified employees and owns state-of-the-art R&D facilities near Dijon, acquired from the international pharmaceutical group Abbott. The Company owns, a proprietary chemical library of over 240,000 molecules as well as integrated biology, chemistry, ADME and pharmacology platforms. Some of the statements contained in this document are not historical facts but rather are statements of future expectations and other forward-looking statements that are based on management's beliefs. These statements reflect such views and assumptions prevailing as of the date of the statements and involve known and unknown risks and uncertainties that could cause future results, performance or future events to differ materially from those expressed or implied in such statements. Please refer to the « Document de Base » filed with the Autorité des Marchés Financiers on July 8, 2016 under n° l.16-066, and its update submitted on January 12, 2017 under n° D.16-0535-A01 for additional information in relation to such factors, risks and uncertainties. Inventiva has no intention and is under no obligation to update or review the forward-looking statements referred to above. Consequently Inventiva accepts no liability for any consequences arising from the use of any of the above statements.


News Article | May 17, 2017
Site: www.businesswire.com

Inventiva (Paris:IVA) makes available the English version of its 2016 Reference Document, which has been filed on April 26, 2017 with the “Autorité des Marchés Financiers (AMF)”. This document is available to the public free of charge, as provided for in applicable legislation, and may be viewed and download on the Company’s website www.inventivapharma.com. The 2016 Reference Document includes the annual financial report, the report of the Chairman of the Board of Directors on the conditions for preparing and organizing the Board’s activities and the internal control procedures, the independent third party report on consolidated human resources, environmental and social information published in the Management Report, the auditors’ reports and information about fees paid to statutory auditors. Inventiva is a biopharmaceutical company specialized in the development of drugs interacting with nuclear receptors, transcription factors and epigenetic modulators. Inventiva’s research engine opens up novel breakthrough therapies against fibrotic diseases, cancers and orphan diseases with substantial unmet medical needs. IVA337, its lead product, is an anti-fibrotic treatment with a strong action mechanism permitting the activation of all three alpha, gamma and delta PPARs (peroxisome proliferator-activated receptors), which play key roles in controlling the fibrotic process. Its anti-fibrotic action targets two initial indications with substantial unmet medical need: NASH, a severe and increasingly prevalent liver disease already affecting over 30 million people in the United States, and systemic sclerosis, a disease with a very high mortality rate and for which there is no approved treatment to date. Inventiva is also developing in parallel, a second clinical product, IVA336, which is a treatment for three different forms of mucopolysaccharidosis: MPS I or Hurler-Scheie syndrome, MPS II or Hunter syndrome and MPS VI also known as Maroteaux-Lamy syndrome. Inventiva has a preclinical stage oncology portfolio. Inventiva benefits from partnerships with world-leading research entities such as the Institut Curie. Two strategic commercial partnerships, one of which is at clinical stage, have also been developed with AbbVie and Boehringer Ingelheim, making Inventiva eligible for preclinical, clinical, regulatory and commercial milestone payments, in addition to royalties on the products resulting from the partnerships. Inventiva employs over 100 highly qualified employees and owns state-of-the-art R&D facilities near Dijon, acquired from the international pharmaceutical group Abbott. The Company owns, a proprietary chemical library of over 240,000 molecules as well as integrated biology, chemistry, ADME and pharmacology platforms. Some of the statements contained in this document are not historical facts but rather are statements of future expectations and other forward-looking statements that are based on management's beliefs. These statements reflect such views and assumptions prevailing as of the date of the statements and involve known and unknown risks and uncertainties that could cause future results, performance or future events to differ materially from those expressed or implied in such statements. Please refer to the « Document de Base » filed with the Autorité des Marchés Financiers on July 8, 2016 under n° l.16-066, and its update submitted on January 12, 2017 under n° D.16-0535-A01 for additional information in relation to such factors, risks and uncertainties. Inventiva has no intention and is under no obligation to update or review the forward-looking statements referred to above. Consequently Inventiva accepts no liability for any consequences arising from the use of any of the above statements.


Patent
Inventiva | Date: 2016-12-28

The invention relates to compounds of formula (I), where R, R1, R2 n, A and Cy have the meanings indicated in the description. The compounds of formula (I) are Nurr-1 modulators.


The invention relates to the use of a pan-PPAR agonist, or of a pharmaceutical composition containing said agonist, for the treatment of a fibrotic condition.


Patent
Inventiva | Date: 2015-02-19

The invention relates to compounds of formula (I). where R, R_(1), R_(2), n, A and Cy have the meanings indicated in the description. The compounds of formula (I) are Nurr-1 modulators.


The invention relates to compounds of formula I The compounds of formula I are useful for the treatment of diseases where inhibition of the YAP/TAZ-TEAD interaction is required.


News Article | November 14, 2016
Site: www.prnewswire.co.uk

ReportsnReports.com adds "Idiopathic Pulmonary Fibrosis - Pipeline Review, H2 2016" to its store providing comprehensive information on the therapeutics under development for Idiopathic Pulmonary Fibrosis (Respiratory), complete with analysis by stage of development, drug target, mechanism of action (MoA), route of administration (RoA) and molecule type. The guide covers the descriptive pharmacological action of the therapeutics, its complete research and development history and latest news and press releases. Complete report on H2 2016 pipeline review of Idiopathic Pulmonary Fibrosis with 78 market data tables and 15 figures, spread across 260 pages is available at http://www.reportsnreports.com/reports/743476-idiopathic-pulmonary-fibrosis-pipeline-review-h2-2016.html . Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal disease characterized by inflammation and scarring of lung tissue and loss of lung function. Symptoms of IPF include dry cough, shortness of breath, especially during or after physical activity, lasting tiredness and weight loss. Risk factors include smoking, environmental exposure, viral infections, family history and abnormal acid reflux. Treatment includes antioxidants, biological response modulators, anti-fibrotic agents and anticoagulants. Companies discussed in this Idiopathic Pulmonary Fibrosis Pipeline Review, H2 2016 report include AdAlta Pty Ltd., Aeolus Pharmaceuticals, Inc., Afferent Pharmaceuticals, Inc., Apellis Pharmaceuticals Inc, ARMO Biosciences, Inc., Asahi Kasei Pharma Corp., Biogen Inc, Bioneer Corporation, BiOrion Technologies B.V., Bristol-Myers Squibb Company, Celgene Corporation, Chrysalis Pharma SAS, Compugen Ltd., Cynata Therapeutics Limited, F. Hoffmann-La Roche Ltd., FibroGen, Inc., FibroStatin SL, Galapagos NV, GenKyoTex S.A., GlaxoSmithKline Plc, Global Blood Therapeutics, Inc., GNI Group Ltd., HEC Pharm Co., Ltd., Histocell S.L., iBio, Inc., Immunomet Therapeutics, Inc., Inventiva, Isarna Therapeutics GmbH, Kadmon Corporation, LLC, Kasiak Research Private Limited, Kolltan Pharmaceuticals, Inc., Kyorin Pharmaceutical Co., Ltd., Lung Therapeutics Inc, Moerae Matrix, Inc., MorphoSys AG, Novartis AG, Nuevolution AB, Pharmaxis Limited, Promedior, Inc., ProMetic Life Sciences Inc., Pulmatrix, Inc., Respira Therapeutics Inc, Ribomic Inc., Saje Pharma, LLC, Samumed LLC, Sanofi Sorrento Therapeutics, Inc., SPR Biosciences LLC, Teva Pharmaceutical Industries Ltd., Therabron Therapeutics, Inc., Vicore Pharma AB and Yuhan Corporation. The Idiopathic Pulmonary Fibrosis (Respiratory) pipeline guide also reviews of key players involved in therapeutic development for Idiopathic Pulmonary Fibrosis and features dormant and discontinued projects. The guide covers therapeutics under Development by Companies /Universities /Institutes, the molecules developed by Companies in Phase III, Phase II, Phase I, IND/CTA Filed, Preclinical and Discovery stages are 1, 14, 13, 1, 49 and 8 respectively for Similarly, the Universities portfolio in Preclinical and Discovery stages comprises 4 and 3 molecules, respectively for Idiopathic Pulmonary Fibrosis. Idiopathic Pulmonary Fibrosis (Respiratory) pipeline guide helps in identifying and tracking emerging players in the market and their portfolios, enhances decision making capabilities and helps to create effective counter strategies to gain competitive advantage. The guide is built using data and information sourced from Global Markets Direct’s proprietary databases, company/university websites, clinical trial registries, conferences, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources. Additionally, various dynamic tracking processes ensure that the most recent developments are captured on a real time basis. The report helps in identifying and tracking emerging players in the market and their portfolios, enhances decision making capabilities and helps to create effective counter strategies to gain competitive advantage. Another newly published market research report titled Bronchiectasis - Pipeline Review, H2 2016 provides comprehensive information on the therapeutic development for Bronchiectasis, complete with comparative analysis at various stages, therapeutics assessment by drug target, mechanism of action (MoA), route of administration (RoA) and molecule type, along with latest updates, and featured news and press releases. It also reviews key players involved in the therapeutic development for Bronchiectasis and special features on late-stage and discontinued projects. The report enhances decision making capabilities and help to create effective counter strategies to gain competitive advantage. It strengthens R&D pipelines by identifying new targets and MOAs to produce first-in-class and best-in-class products. Companies Involved in Therapeutics Development are Alitair Pharmaceuticals, Inc., Bayer AG, Grifols, S.A., Insmed Incorporated, Kamada Ltd., Polyphor Ltd., Raptor Pharmaceutical Corp., Recipharm AB, Savara Inc. and Vertex Pharmaceuticals Incorporated. Bronchiectasis Pipeline market research report of 84 pages is available at http://www.reportsnreports.com/reports/743455-bronchiectasis-pipeline-review-h2-2016.html . ReportsnReports.com is your single source for all market research needs. Our database includes 500,000+ market research reports from over 100+ leading global publishers & in-depth market research studies of over 5000 micro markets. With comprehensive information about the publishers and the industries for which they publish market research reports, we help you in your purchase decision by mapping your information needs with our huge collection of reports. Connect With Us on:


The present invention relates to a method of treatment of a mucopolysaccharidosis with 4-methyl-2-oxo-2H-1-benzopyran-7-yl-5-thio--D-xylopyranoside.


Receive press releases from IQ4I Research & Consultancy Pvt. Ltd.: By Email This pipeline analysis gives comprehensive insights on drugs being developed for the treatment of NASH & their various stages of development in 144 slide decks. This pipeline focuses on novel pharmacologic drugs & regenerative medicines covering small molecules, antibodies, stem cell therapies, recombinant proteins and RNA-based therapeutics. Boston, MA, February 24, 2017 --( This report enables Pharmaceutical/Biotech companies, Academic institutes, Individual researchers, Investors, Medical technology companies, Service providers and other associated stake holders to identify and analyze the available licensing/collaborative commercial opportunities in the Non-alcoholic steatohepataitis (NASH) drugs market. The report also provides strategic insights on some of the molecules that are yet to be launched in the next few years. Some of the key sections covered in the report are given below: *Epidemiology -In this section, epidemiology of NASH is reviewed to understand potential significance and impact of the disease. -Global & US prevalence rates. *Hot Targets, Mechanisms & Therapies -In this section, various NASH associated targets, mechanism and upcoming therapies are discussed. Also, covers novel targets in early research for NASH along with disease progression biomarkers associated with NASH (Inflammatory, apoptosis, fibrosis). *Market analysis -In market analysis section, global NASH drugs market is indicated along with the estimated Peak sales ($) of leading clinical stage drugs forecasted from 2019-2025. -Forecasting model for NASH market. -NASH market dynamics -NASH Market and estimated Peak sales of 8 clinical candidates (OCA-Intercept, Aramchol-Galmed, -GR-MD-02-Gilead, Cenicriviroc-Tobira, Simtuzumab-Gilead, Remo Biphasic-Avolynt, IVA 337- Inventiva Pharma, GFT505-Genfit) -NASH related deals analysis with financials (upfront, milestones and royalties) -Funding scenario in NASH market *Pipeline Analysis -Pipeline analysis was carried to get deeper insights on various treatment modalities in discovery, preclinical & development section, pipelines from major companies were identified and Potential targets were reported along with Mechanism of action, Current development status & nature of molecule. Pipeline analysis by developmental stage (Discovery to Clinical development) -Pipeline analysis by modalities --Monoclonal Antibodies pipeline analysis --RNA-therapeutics pipeline analysis --Recombinant protein pipeline analysis -Pipeline analysis by leading players & Target analysis -Drug analysis based on mechanism (Anti-Inflammatory, Anti-fibrotic & Metabolic) *Key Players Analysis -The key player’s analysis section provides an in-depth understanding of various companies working on Nonalcoholic steatohepatitis (NASH) and their Pipelines with development phase as well as understanding partnering strategies such as deals entered by the company. -Global key players overview -Global key players Pipeline data (Discovery, Pre-clinical & Clinical development) -Global key players deals (Collaborations, Licensing, Service agreements, grants, funds) Boston, MA, February 24, 2017 --( PR.com )-- “Non-alcoholic steatohepataitis (NASH) Pipeline Analysis” gives comprehensive insights on the various drugs being developed for the treatment of NASH. The report covers all the drugs that are in various phases of development (Discovery, Preclinical & Clinical). The pipeline focuses on novel pharmacologic drugs & regenerative medicines covering small molecules, antibodies, stem cell therapies, recombinant proteins and RNA-based therapeutics, but excludes symptom relief drugs, generic combinations and supplemental drugs. The report also covers some of the hot targets in research for NASH treatments and NASH related biomarkers.This report enables Pharmaceutical/Biotech companies, Academic institutes, Individual researchers, Investors, Medical technology companies, Service providers and other associated stake holders to identify and analyze the available licensing/collaborative commercial opportunities in the Non-alcoholic steatohepataitis (NASH) drugs market. The report also provides strategic insights on some of the molecules that are yet to be launched in the next few years.Some of the key sections covered in the report are given below:*Epidemiology-In this section, epidemiology of NASH is reviewed to understand potential significance and impact of the disease.-Global & US prevalence rates.*Hot Targets, Mechanisms & Therapies-In this section, various NASH associated targets, mechanism and upcoming therapies are discussed. Also, covers novel targets in early research for NASH along with disease progression biomarkers associated with NASH (Inflammatory, apoptosis, fibrosis).*Market analysis-In market analysis section, global NASH drugs market is indicated along with the estimated Peak sales ($) of leading clinical stage drugs forecasted from 2019-2025.-Forecasting model for NASH market.-NASH market dynamics-NASH Market and estimated Peak sales of 8 clinical candidates (OCA-Intercept, Aramchol-Galmed,-GR-MD-02-Gilead, Cenicriviroc-Tobira, Simtuzumab-Gilead, Remo Biphasic-Avolynt, IVA 337- Inventiva Pharma, GFT505-Genfit)-NASH related deals analysis with financials (upfront, milestones and royalties)-Funding scenario in NASH market*Pipeline Analysis-Pipeline analysis was carried to get deeper insights on various treatment modalities in discovery, preclinical & development section, pipelines from major companies were identified and Potential targets were reported along with Mechanism of action, Current development status & nature of molecule. Pipeline analysis by developmental stage (Discovery to Clinical development)-Pipeline analysis by modalities--Monoclonal Antibodies pipeline analysis--RNA-therapeutics pipeline analysis--Recombinant protein pipeline analysis-Pipeline analysis by leading players & Target analysis-Drug analysis based on mechanism (Anti-Inflammatory, Anti-fibrotic & Metabolic)*Key Players Analysis-The key player’s analysis section provides an in-depth understanding of various companies working on Nonalcoholic steatohepatitis (NASH) and their Pipelines with development phase as well as understanding partnering strategies such as deals entered by the company.-Global key players overview-Global key players Pipeline data (Discovery, Pre-clinical & Clinical development)-Global key players deals (Collaborations, Licensing, Service agreements, grants, funds) Click here to view the list of recent Press Releases from IQ4I Research & Consultancy Pvt. Ltd.

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