Fragoso J.M.,Interventional Genetic Study Group in Cardiovascular Diseases |
Zuniga-Ramos J.,Instituto Nacional Of Enfermedades Respiratorias Ismael Cosio Villegas |
Villegas-Torres B.E.,Instituto Nacional Of Medicina Genomica |
Cruz-Lagunas A.,Instituto Nacional Of Enfermedades Respiratorias Ismael Cosio Villegas |
And 7 more authors.
Experimental and Molecular Pathology | Year: 2015
The aim of the present study was to establish the role of IL-6 and TGF-β1 gene polymorphisms in the risk of developing in-stent restenosis. Two IL-6 [rs1800796 (-572 G>C), rs2069827 (-1426 T>G)] and two TGF-β1 [rs1800469 (-509 T>C), rs1800470 (T29C)] gene polymorphisms were analyzed by 5' exonuclease TaqMan genotyping assays in a group of 244 patients, who underwent coronary artery stenting. Basal and procedure coronary angiography were analyzed, looking for angiographic predictors of restenosis and follow-up angiography was performed to screen for binary restenosis. Under the dominant and additive models adjusted for hypertension, stable angina, stent used, and diameter of stent, the TGF-β1 T29C (rs1800470) polymorphism was significantly associated with an increase risk of restenosis when compared to patients without restenosis (OR=2.06, 95% CI: 1.03-4.11, PDom=0.034 and OR=1.64, 95% CI: 1.09-2.45, PAdd=0.016). TGF-β1 polymorphisms were in linkage disequilibrium and one haplotype (TT) was significantly increased in patients with restenosis when compared to patients without restenosis (OR=2.03, P=0.041). In summary, our results suggest that the TGF-β1 T29C gene polymorphism could be involved in the risk of developing restenosis after coronary stent placement. © 2014.