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Saint Petersburg, Russia

Pozharitskaya O.N.,Interregional Fund Adaptation | Shikov A.N.,Interregional Fund Adaptation | Makarova M.N.,Interregional Fund Adaptation | Kosman V.M.,Interregional Fund Adaptation | And 4 more authors.
Phytomedicine | Year: 2010

The anti-inflammatory potential of three doses of an aqueous infusion of aerial parts Bidens tripartita L. against carrageenan-induced acute paw edema in rats was investigated. A phytochemical study and qualitative-quantitative analyses revealed the presence of flavonoids, tannins, polysaccharides, phenols, amino acids, ascorbic acid, organic acids and polyacetylenes. Infusion doses of 20 ml/kg body wt. exhibited significant anti-inflammatory activity in rats, as compared with indomethacin. In addition, the infusion showed analgesic properties in a hot-plate test and antipyretic properties in carrageenan-induced local hyperthermia, both in rats. The effects were dose-dependent. Our results provide evidence for the potential usefulness of B. tripartita infusion in the treatment of inflammatory disorders. © 2009 Elsevier GmbH. All rights reserved.

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