Interregional Clinical Diagnostic Center

Kazan, Russia

Interregional Clinical Diagnostic Center

Kazan, Russia
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Pokrovskii A.V.,Institute Of Surgery Named After Av Vishnevsky Under The Rf Ministry Of Public Health | Ignat'ev I.M.,Interregional Clinical Diagnostic Center | Volodiukhin M.Iu.,Interregional Clinical Diagnostic Center | Gradusov E.G.,Moscow Medical Academy
Angiologiia i sosudistaia khirurgiia = Angiology and vascular surgery | Year: 2016

The present study was aimed at assessing initial results of hybrid operations in obstructive lesions of the iliac-femoral veins in patients with post-thrombotic disease (PTD). Hybrid operations [open endovenectomy from the common femoral vein (CFV) with creation of an arteriovenous fistula + stenting of iliac veins] were performed carried out in a total of eleven patients with PTD. Of these, there were 7 men and 4 women aged from 34 to 52 years (mean age - 42.8±7 years). All patients had severe-degree chronic venous insufficiency (CVI). The distribution of patients according to the CEAP classification was as follows: C4a - 2 patients, C4b - 4 patients, C5 - 4 subjects, C6 - 1 patient. The time having elapsed since a newly onset episode of acute iliac-femoral venous thrombosis varied from 2 to 12 years (averagely - 7.1±3.3 years). The degree of manifestation of PTD was determined by means of the Villalta-Pradoni scale before and 6 months after the operation. Instrumental methods of study included ultrasound duplex scanning (USDS), magnetic resonance and/or multispiral computed venography, and contrast-enhanced X-ray venography. The technical success of the procedure amounted to 91%. In one patient with occlusion of the common and external iliac veins we failed to perform recanalization and stenting. A further one patient developed in-stent and CFV thrombosis on the second postoperative day. An attempt of catheter thrombolysis turned out unsuccessful. There were no wound complications in the postoperative period. Neither was pulmonary artery thromboembolism registered. The dynamic control was carried out by means of USDS before discharge from hospital and at 1, 3 and 6 months after the intervention. The outcomes of hybrid operations after 6 months were followed up in five patients. Secondary patency rate of the stented iliac veins amounted to 100%. No relapses of trophic ulcers were observed. According to the Villalta-Prandoni scale the value of the median of the composite index decreased from 15 to 7 (p=0.012). The first experience with hybrid operations for obstructive lesions of veins of the iliac-femoral segment demonstrated their high efficacy and safety. Efficiency of the operation was confirmed by significant clinical improvement and good results of patency of the restored-repaired segments of veins.


Objective – to compare different doses of escitalopram (Cipralex) in the prophylaxis of dementia in patients with depression and moderate cognitive dysfunction on the background of chronic cerebral ischemia. Materials and methods. Two groups of patients, aged 65–78 years, with chronic cerebral ischemia and mild-moderate depression and moderate cognitive dysfunction were studied and treated with different doses of escitalopram: 30 patients received escitalopram at a dose of 5 mg/day throughout the treatment period; 42 patients received escitalopram at a dose of 5 mg/day for the fi rst week and then 10 mg/day. Treatment duration was six months and the observation period was eight months. Results and conclusions. Escitalopram was shown to be effective not only in the treatment of depression-associated cognitive dysfunction in patients with chronic cerebral ischemia but also in decreasing the risk of dementia in the long term. The effectiveness of the prophylaxis of dementia was found to depend on the escitalopram dose used. © 2017, Springer Science+Business Media New York.


PubMed | Interregional Clinical Diagnostic Center, St. Petersburg State Medical University, Russian Academy of Sciences and Chelyabinsk State Medical Academy
Type: Journal Article | Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova | Year: 2015

The analysis of the results of treatment of the Russian patient population in the frame of international, multicenter, non-interventional study of CD, the primary purpose of which was to determine the response rate to therapy with BTA at the peak of the effect: after one course of injections in settings of routine practice, as well as the results of application of modern definition for response to treatment with BTA.In Russia 60 patients with idiopathic CD were included. Patients were classified as responders according to the following 4 criteria: effect size (improvement by 25% assessed by TWSTRS); effect duration: 12 weeks interval between the BTA injection and the day when the patient reported a decrease of clinical effect, indicating the need for repeated treatment; good tolerability of treatment (no treatment-related serious adverse events (AEs) during the study period); patient-reported Clinical Global Improvement (CGI) score is +2 (significant improvement) or +3 (very significant improvement) at the visits 2 or 3.In the Russian population, patients with a 25% improvement by TWSTRS scale at visit 2 (peak effect) accounted for 88.3%. Most of patients (81.6%) and physicians (81.7%) evaluated the efficacy of therapy as a significant improvement or very significant improvement by CGI. The criterion of the effect duration was achieved in 50% of cases. The BTA therapy was well tolerated (no severe AEs related to treatment) in 98.3% of patients. Overall, 40% of all patients met all the criteria for response to BTA treatment. According to the analysis of the general population, a high degree of response was observed for the effect size (73.6%), tolerability (97.5%) and patient-reported global clinical improvement (69.8%). Subjective assessment of the duration of the effect was achieved in 49.3% of patients, with 28.6% of patients considered as responders. Most patients met three of the four criteria. The proposed multifactorial definition of response may be of practical use for routine practice.


Galyavich A.S.,Kazan State Medical University | Rafikov A.Yu.,Interregional Clinical Diagnostic Center
Kardiologiya | Year: 2015

The review contains contemporary data of assessment on right ventricular (RV) function by various instrumental methods of investigation. Among all these methods multispiral computed tomography (MSCT) appears to be most perspective. Accuracy and reproducibility of measurements of RV function by MSCT and comparable with those of magnetic resonance tomography. The uniqueness of MSCT is its ability to produce complex simultaneous evaluation not only of RV-functional parameters but also of other anatomical structures located in the scanning field.


PubMed | Interregional Clinical Diagnostic Center and Kazan State Medical University
Type: Journal Article | Journal: Angiologiia i sosudistaia khirurgiia = Angiology and vascular surgery | Year: 2016

Presented herein is a clinical case report regarding treatment of a patient after endovascular prosthetic repair of an abdominal aortic aneurysm, complicated by ischaemic necrosis of the sigmoid colon. This is followed by analysing the causes of the development of the complication, as well as by a brief review of the literature concerning this problem.


PubMed | Interregional Clinical Diagnostic Center, Kazan State Medical Academy and Kazan Federal University
Type: Journal Article | Journal: Biomeditsinskaia khimiia | Year: 2016

Correlations between biochemical and immunological markers of programmed cell death (apoptosis), and the functional state of the thyroid gland (hyperthyroidism, euthyroidism, hypothyroidism) have been investigated in autoimmune thyroiditis (AT) (also known as chronic autoimmune thyroiditis). Annexin V, TRAIL and TNF-a, as well as DNA-hydrolyzing antibodies were used as the main markers. Increased levels of TRAIL were found in the serum of AT patients (hyperthyroidism>hypothyroidism>euthyroidism) compared with healthy individuals. The highest frequency of antibodies to denatured DNA (Abs-dDNA) had the highest frequency in AT patients (97%) compared with healthy controls. Among these patients, 75% had hyperthyroidism, 85% had hypothyroidism, and 84.7% had euthyroidism. Abs hydrolyzing activity demonstrated correlation dependence with symptoms of the thyroid dysfunction.


Shakhmaeva I.I.,Kazan Federal University | Saifullina D.V.,Kazan Federal University | Sattarova L.I.,Interregional Clinical Diagnostic Center | Abdullin T.I.,Kazan Federal University
Analytical and Bioanalytical Chemistry | Year: 2011

We designed an electrochemical sensor based on a carbon nanotube modified electrode (ME) to analyze DNA-cleaving activity. The cleavage of high molecular weight DNA resulted in an increase in the oxidation current from DNA guanine nucleotides due to a change in DNA adsorptive behavior on the surface of the ME. DNA digestion with DNAse I was accompanied by a linear increase in the DNA signal in proportion to the enzyme activity. We then proposed an assay based on the sensor for the direct assessment of the total deoxyribonuclease activity of blood serum as well as the separate detection of DNAse I and DNA abzymes. The assay was applied to analyze deoxyribonucleases in sera from 21 healthy donors and 17 patients with autoimmune thyroiditis. Our results show that the response of the sensor to DNA cleavage by blood deoxyribonucleases is a promising diagnostic criterion for autoimmune thyroiditis. This sensor can be implemented in a disposable screen-printed electrode format for application in clinical laboratories. © 2011 Springer-Verlag.


PubMed | Interregional Clinical Diagnostic Center and Kazan Federal University
Type: | Journal: BioMed research international | Year: 2017

The search for adequate markers of atherosclerotic plaque (AP) instability in the context of assessment of the ischemic stroke risk in patients with atherosclerosis of the carotid arteries as well as for solid physical and chemical factors that are connected with the AP stability is extremely important. We investigate the inner lining of the carotid artery specimens from the male patients with atherosclerosis (27 patients, 42-64 years old) obtained during carotid endarterectomy by using different analytical tools including ultrasound angiography, X-ray analysis, immunological, histochemical analyses, and high-field (3.4T) pulse electron paramagnetic resonance (EPR) at 94GHz. No correlation between the stable and unstable APs in the sense of the calcification is revealed. In all of the investigated samples, the EPR spectra of manganese, namely, Mn


Zhitkova J.V.,Interregional Clinical Diagnostic Center
Zhurnal Nevrologii i Psihiatrii imeni S.S. Korsakova | Year: 2015

Objective — to compare different doses of escitalopram (cipralex) in the prevention of dementia in patients with depression and moderate cognitive dysfunction associated with chronic brain ischemia. Material and methods. Two groups of patients, aged 65—78 years, with chronic brain ischemia and mild or moderate depression with moderate cognitive dysfunction were treated with different doses of escitalopram: 30 patients received 5 mg daily during all treatment period; 42 patients — 5 mg daily during the first week and 10 mg from the second week of treatment. The treatment lasted for 6 months; the period of observation was 8 months. Results and conclusion. The efficacy of escitalopram is demonstrated not only for the treatment of depression associated with cognitive dysfunction in patients with chronic brain ischemia but for decrease of the risk of dementia in long-term period. © 2015, Media Sphera. All Rights Reserved.


PubMed | Interregional Clinical Diagnostic Center
Type: Comparative Study | Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova | Year: 2015

to compare different doses of escitalopram (cipralex) in the prevention of dementia in patients with depression and moderate cognitive dysfunction associated with chronic brain ischemia.Two groups of patients, aged 65-78 years, with chronic brain ischemia and mild or moderate depression with moderate cognitive dysfunction were treated with different doses of escitalopram: 30 patients received 5 mg daily during all treatment period; 42 patients - 5 mg daily during the first week and 10 mg from the second week of treatment. The treatment lasted for 6 months; the period of observation was 8 months.The efficacy of escitalopram is demonstrated not only for the treatment of depression associated with cognitive dysfunction in patients with chronic brain ischemia but for decrease of the risk of dementia in long-term period.

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