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Galyavich A.S.,Kazan State Medical University | Rafikov A.Yu.,Interregional Clinical Diagnostic Center

The review contains contemporary data of assessment on right ventricular (RV) function by various instrumental methods of investigation. Among all these methods multispiral computed tomography (MSCT) appears to be most perspective. Accuracy and reproducibility of measurements of RV function by MSCT and comparable with those of magnetic resonance tomography. The uniqueness of MSCT is its ability to produce complex simultaneous evaluation not only of RV-functional parameters but also of other anatomical structures located in the scanning field. Source

Objective — to compare different doses of escitalopram (cipralex) in the prevention of dementia in patients with depression and moderate cognitive dysfunction associated with chronic brain ischemia. Material and methods. Two groups of patients, aged 65—78 years, with chronic brain ischemia and mild or moderate depression with moderate cognitive dysfunction were treated with different doses of escitalopram: 30 patients received 5 mg daily during all treatment period; 42 patients — 5 mg daily during the first week and 10 mg from the second week of treatment. The treatment lasted for 6 months; the period of observation was 8 months. Results and conclusion. The efficacy of escitalopram is demonstrated not only for the treatment of depression associated with cognitive dysfunction in patients with chronic brain ischemia but for decrease of the risk of dementia in long-term period. © 2015, Media Sphera. All Rights Reserved. Source

Biktagirova E.M.,Kazan Federal University | Sattarova L.I.,Interregional Clinical Diagnostic Center | Vagapova G.R.,Kazan State Medical Academy | Skibo Y.V.,Kazan Federal University | And 3 more authors.
Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry

Correlations between biochemical and immunological markers of programmed cell death (apoptosis), and the functional state of the thyroid gland (hyperthyroidism, euthyroidism, hypothyroidism) have been investigated in autoimmune thyroiditis (AT) (also known as chronic autoimmune thyroiditis). Annexin V, TRAIL and TNFα, as well as DNA-hydrolyzing antibodies were used as the main markers. Increased levels of TRAIL were found in the serum of AT patients (hyperthyroidism > hypothyroidism > euthyroidism) compared with healthy individuals. The highest frequency of antibodies to denatured DNA (Abs-dDNA) had the highest frequency in AT patients (97%) compared with healthy controls. Among these patients, 75% had hyperthyroidism, 85% had hypothyroidism, and 84.7% had euthyroidism. Abs hydrolyzing activity demonstrated correlation dependence with symptoms of the thyroid dysfunction. © 2015, Pleiades Publishing, Ltd. Source

Khafizova I.F.,Kazan State Medical University | Zalyalova Z.A.,Kazan State Medical University | Baranova E.A.,Interregional Clinical Diagnostic Center | Khakimova A.R.,Kazan State Medical University | And 2 more authors.
Zhurnal Nevrologii i Psihiatrii imeni S.S. Korsakova

Multiple sclerosis (MS) is a disease with multicentric lesions of central nervous system. These numerous lesions can cause a lot of different symptoms. Sometimes these signs are atypical and make difficulties for MS diagnosing. Hyperkinesis is extremely rare manifestation of MS especially if it concerns spinal myoclonus. Spinal myoclonic jerks can be caused by various focal damages of neuraxis including demyelination lesions. This report describes the case of spinal segmental myoclonus as an unusual manifestation of MS. The patient was diagnosed definite MS according to the McDonald criteria (2010). The nature of movement disorders was defined by careful neurologic and neurophysiologic examination. These movement disorders were reliably caused by demyelinating type lesions in the cervical cord. Source

Timerbaeva S.L.,Russian Academy of Sciences | Khasanova D.R.,Interregional Clinical Diagnostic Center | Korenko L.A.,St. Petersburg State Medical University | Belskaya G.N.,Chelyabinsk State Medical Academy
Zhurnal Nevrologii i Psihiatrii imeni S.S. Korsakova

Objective. The analysis of the results of treatment of the Russian patient population in the frame of international, multicenter, noninterventional study of CD, the primary purpose of which was to determine the response rate to therapy with BTA at the peak of the effect: After one course of injections in settings of routine practice, as well as the results of application of modern definition for “response” to treatment with BTA. Material and methods. In Russia 60 patients with idiopathic CD were included. Patients were classified as «responders» according to the following 4 criteria: Effect size (improvement by ≥25% assessed by TWSTRS); effect duration: ≥12 weeks interval between the BTA injection and the day when the patient reported a decrease of clinical effect, indicating the need for repeated treatment; good tolerability of treatment (no treatment-related serious adverse events (AEs) during the study period); patient-reported Clinical Global Improvement (CGI) score is +2 («significant improvement») or +3 («very significant improvement») at the visits 2 or 3. Results and conclusion. In the Russian population, patients with a ≥25% improvement by TWSTRS scale at visit 2 (peak effect) accounted for 88.3%. Most of patients (81.6%) and physicians (81.7%) evaluated the efficacy of therapy as a «significant improvement» or «very significant improvement» by CGI. The criterion of the effect duration was achieved in 50% of cases. The BTA therapy was well tolerated (no severe AEs related to treatment) in 98.3% of patients. Overall, 40% of all patients met all the criteria for response to BTA treatment. According to the analysis of the general population, a high degree of response was observed for the effect size (73.6%), tolerability (97.5%) and patient-reported global clinical improvement (69.8%). Subjective assessment of the duration of the effect was achieved in 49.3% of patients, with 28.6% of patients considered as responders. Most patients met three of the four criteria. The proposed multifactorial definition of «response» may be of practical use for routine practice. © 2015, Media Sphera. All rights reserved. Source

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