Saint Petersburg, Russia
Saint Petersburg, Russia

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Dadali V.A.,St. Petersburg State Medical Academy | Tutelyan V.A.,Russian Academy of Medical Sciences | Dadali Y.V.,Interregional Center Adaptogen | Kravchenko L.V.,Russian Academy of Medical Sciences
Voprosy Pitaniia | Year: 2010

The review provides data on the structure and the major biotransformation pathways of the most prevalent carotenoids. Eventual mechanisms of their antiradical and antioxidant activity in different model systems in vitro are thoroughly discussed. Special attention is paid to carotenoids as potential membrane protector.

Shikov A.N.,Saint Petersburg Institute of Pharmacy | Kundracikova M.,Institute of Biology | Palama T.L.,University of Reunion Island | Pozharitskaya O.N.,Saint Petersburg Institute of Pharmacy | And 7 more authors.
Phytochemistry Letters | Year: 2010

The herb Gnaphalium uliginosum L. is an annual plant widely used in Russian and Bulgarian phytotherapy in the treatment of hypertension, thrombophlebitis, phlebothrombosis and ulcers. Decoction and infusion of G. uliginosum are known to possess anti-inflammatory, astringent, and antiseptic properties. Oil extracts are used in the treatment of laryngitis, upper respiratory catarrh and tonsillitis. However, there is still lack of information about the active compounds. Ten phenolic compounds have been identified from the aerial parts of G. uliginosum including seven flavonoid glucosides and three phenylpropanoids. Their chemical structures were elucidated on the basis of 1D and 2D NMR and HRESIMS. Among the identified compounds the first full assignments of the 1H and 13C NMR spectra of, 5,7,4′-trihydroxy-6,3′-dimethoxyflavone-7-O-β-d-(6″-O-caffeoyl)-glucopyranoside are firstly reported in this paper. © 2009 Phytochemical Society of Europe.

Hellstrom J.K.,Mtt Agrifood Research Finland | Shikov A.N.,Interregional Center Adaptogen | Makarova M.N.,Interregional Center Adaptogen | Pihlanto A.M.,Mtt Agrifood Research Finland | And 5 more authors.
Journal of Functional Foods | Year: 2010

The blood pressure-lowering properties of lyophilized chokeberry juice and polyphenols were monitored using in vitro angiotensin-converting enzyme (ACE) inhibition measurement and a 10day in vivo study with spontaneously hypertensive rats (SHR). Juice and polyphenols indicated weak ACE-inhibitory activity. The IC50 values for polyphenols and juice were 1.5-2.5 and 4.5mg dry matter/ml, respectively. In the SHR study the blood pressure-lowering effects of juice and polyphenol extract seemed to be short-term and were generally highest after 3h from administration (50mg/kg/day) when mean reductions in systolic blood pressure were 20±8 and 15±7mmHg, respectively. Corresponding mean decreases in diastolic blood pressure were 23±6 and 13±2mm Hg in juice and polyphenol groups, respectively. It was concluded that both chokeberry juice and polyphenols had blood pressure-lowering effects. We hypothesize that chokeberry polyphenols enhance endothelial nitric oxide production with an ACE-independent mechanism, e.g. by activation of endothelial nitric oxidase enzyme; this is yet to be verified. © 2010 Elsevier Ltd.

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