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Jakubcova R.,Radiologicka Klinika LF MU a FN Brno | Moulis M.,Ustav Patologie LF MU a FN | Salek D.,Interni hematoonkologicka klinika FN | Foukal J.,Radiologicka Klinika LF MU a FN Brno
Ceska Radiologie | Year: 2010

Aim. On the basis of correlation of ultrasound and histological findings to determine changes in the structure of examined benign and malignant lymph nodes, that led to various types of enhancement in contrast-enhanced ultrasound examination. Method. 78 patients with peripheral lymphadenopathy were examined from January 2008 to July 2009 (27 women and 51 men, age 22-86 years), total number of 82 lymph nodes were extirpated. All patients were examined with Philips iU22 ultrasound machine with 17MHz probe natively and with 9MHz probe after intravenous application of 1.5 ml sulphur hexafluoride contrast agent (SonoVue®, Bracco, Italy). According to postcontrast enhancement lymph nodes were divided into benign and malignant group. Lymph nodes were subsequently extirpated and examined histologically. Ultrasound and histological findings were correlated. Results. The overall accuracy of the method was 92,7% for CEUS. In total 76 lymph nodes (92,7%) were correctly evaluated in terms of their benign or malignant changes. Five histologically benign lymph nodes (6,1%) were incorrectly identified as malignant ones. One malignant node was incorrectly classified as benign by CEUS. In most cases of malignant lymphadenopathy it was possible to distinguish between metastasis and lymphoproliferative disorder. Conclusion. Various processes developing in the lymph node are also reflected in the macroscopic image of the node in contrast-enhanced ultrasound examination. Depending on the type of contrast agent distribution in the node, we can assess the maintenance or, on the contrary, disappearance of its normal structure in most cases, and thus to distinguish between benign and malignant process. Source


Stankova M.,Radiologicka klinika FN | Andrasina T.,Radiologicka klinika FN | Sedmik J.,Radiologicka klinika FN | Valek V.,Radiologicka klinika FN | And 2 more authors.
Ceska Radiologie | Year: 2015

Aim: To evaluate the survival of patients with hepatocellular carcinoma (HCC) treated by transarterial chemoembolization (TACE) with drug-eluting beads, to evaluate the correlation of the length of survival with the factors related to primary liver tumour and factors related to interventions, treatment and response to treatment. Another aim is to evaluate the interobserver variability of measurement in the evaluation response to treatment using RECIST and mRECIST criteria and volumetry. Methods: The total of 49 patients treated in the University Hospital Brno with the diagnosis of HCC were included in this retrospective study. The tumour range was evaluated on the CT/MR input and output by two independent doctors. The survival of the patients was evaluated since the date of the first TACE, in relation to well-known factors effecting the treatment of HCC. The survival was evaluated by the Kaplan-Meier method and the differences in survival by the logrank test. The interobserver variability was determined by using Pearson and Spearman correlation coefficient. Results: The strongest correlation has been proven between the length of survival and determination of the viable part of tumour using volumetry and the ratio viable/aviable parts of the tumour. The median of survival since the first performed TACE is 17.1 months. The evaluation of the response to treatment using RECIST and mRECIST criteria and volumetry has been proven with statistically significant small interobserver variability; however, the best result was achieved by using volumetric analysis. Conclusion: TACE with drug-eluting beads is a modern method of treatment of HCC. When evaluating the response to treatment, it is convenient to use volumetric analysis. Source


Maisnar V.,II. interni klinika OKH | Pelcova J.,Interni hematoonkologicka klinika FN | Klimes D.,Institute Biostatistiky A Analyz | Sandecka V.,Interni hematoonkologicka klinika FN | And 3 more authors.
Onkologie | Year: 2011

Registry of monoclonal gammopathies together with the programme CRAB represent currently two main projects of the Czech Myeloma Group. The purpose of this project is the prospective data analysis of monoclonal gammopathies patients in the region of the middle and also the east Europe including incidence of diseases, therapeutical modalities used, the treatment results and the most frequent adverse events of therapy. It is ambitious project which could help us to improve the care about patients with monoclonal gammopathies. Source

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