Bullon P.,University of Seville |
Roman-Malo L.,University of Seville |
Marin-Aguilar F.,University of Seville |
Alvarez-Suarez J.M.,Marche Polytechnic University |
And 6 more authors.
Pharmacological Research | Year: 2015
Oxidative stress is implicated in several infectious diseases. In this regard, lipopolysaccharide (LPS), an endotoxic component, induces mitochondrial dysfunction and oxidative stress in several pathological events such as periodontal disease or sepsis. In our experiments, LPS-treated fibroblasts provoked increased oxidative stress, mitochondrial dysfunction, reduced oxygen consumption and mitochondrial biogenesis. After comparing coenzyme Q10 (CoQ10) and N-acetylcysteine (NAC), we observed a more significant protection of CoQ10 than of NAC, which was comparable with other lipophilic and hydrophilic antioxidants such as vitamin E or BHA respectively. CoQ10 improved mitochondrial biogenesis by activating PGC-1α and TFAM. This lipophilic antioxidant protection was observed in mice after LPS injection. These results show that mitochondria-targeted lipophilic antioxidants could be a possible specific therapeutic strategy in pharmacology in the treatment of infectious diseases and their complications. © 2014 Elsevier Ltd. All rights reserved.
Gonzalez-Nicieza C.,University of Oviedo |
Alvarez-Fernandez M.I.,University of Oviedo |
Pizarro-Garcia C.,University of Oviedo |
Oliva-Gonzalez A.O.,International University of Mexico
Environmental Earth Sciences | Year: 2014
The storage of CO2 in unused coal mines is a viable option for reducing emissions of CO2, whose accumulation in the atmosphere is one of the main contributors to global warming. Understanding CO2 behaviour and storage capacity of the coal is an important first step before injecting the CO2. We used experimental equipment to extract coal from a mine and to obtain a representative sample of both its internal structure (in terms of cleats, macropores, mesopores and micropores) and occluded gases. Storage capacity was studied in terms of variations in gas pressure. The adsorption isotherm was experimentally obtained applying a procedure specifically designed to avoid altering the coal. An unused coal bed was selected to determine how much CO2 it could adsorb and to study the feasibility of storing power plant CO2 in this kind of mine. © 2013 Springer-Verlag Berlin Heidelberg.
PubMed | University of the Atlantic, International University of Mexico, Marche Polytechnic University, University of Granada and University of the Americas in Chile
Type: | Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association | Year: 2017
A common denominator in the pathogenesis of most chronic inflammatory diseases is the involvement of oxidative stress, related to ROS production by all aerobic organisms. Dietary antioxidants from plant foods represent an efficient strategy to counteract this condition. The aim of the present study was to evaluate the protective effects of strawberry extracts on inflammatory status induced by E. Coli LPS on RAW 264.7 macrophages by measuring the main oxidative and inflammatory biomarkers and investigating the molecular pathways involved. Strawberry pre-treatment efficiently counteracted LPS-induced oxidative stress reducing the amount of ROS and nitrite production, stimulating endogenous antioxidant enzyme activities and enhancing protection against lipid, protein and DNA damage (P<0.05). Strawberry pre-treatment exerted these protective effects primarily through the activation of the Nrf2 pathway, which is markedly AMPK-dependent and also by the modulation of the NF-kB signalling pathway. Finally, an improvement in mitochondria functionality was also detected. The results obtained in this work highlight the health benefit of strawberries against inflammatory and oxidative stress in LPS-stimulated RAW 264.7 macrophages, investigating for the first time the possible involved molecular mechanisms.
Larraraga-Moreno M.,Polytechnic University of the State of Morelos |
Pineda-Mendez F.J.,International University of Mexico
IMSCI 2014 - 8th International Multi-Conference on Society, Cybernetics and Informatics, Proceedings | Year: 2014
Innovation is a key element that shifts competitive advantages for enterprises not matter their size and activity. For small and medium enterprises (SME) the challenge is imperative, they have to acquire the ability to develop innovation and technology as a resource to develop their strategies and achieve goals. The Internet has become a virtual place where customers are sharing and communicating information about their experiences with the enterprises. One important tool that offers a platform to make this interaction is digital social networks. The SME sector in Mexico has an important participation in the economy of the country. Finding a model to improve the management of innovation and technology will allow giving this sector the opportunity to take advantage of the information and interactions that are taking place in digital social networks.
Pistollato F.,University of the Atlantic |
Pistollato F.,International University of Mexico |
Giampieri F.,University of the Atlantic |
Giampieri F.,Marche Polytechnic University |
And 2 more authors.
Food and Chemical Toxicology | Year: 2015
In the last decades cancer has been considered as an epigenetic dysfunction, given the profound role of diet and lifestyle in cancer prevention and the determination of cancer risk. A plethora of recent publications have addressed the specific role of several environmental factors, such as nutritional habits, behavior, stress and toxins in the regulation of the physiological and cancer epigenome. In particular, plant-derived bioactive nutrients have been seen to positively affect normal cell growth, proliferation and differentiation and also to revert cancer related epigenetic dysfunctions, reducing tumorigenesis, preventing metastasis and/or increasing chemo and radiotherapy efficacy. Moreover, virtually all cancer types are characterized by the presence of cancer stem cell (CSC) subpopulations, residing in specific hypoxic and acidic microenvironments, or niches, and these cells are currently considered responsible for tumor resistance to therapy and tumor relapse. Modern anti-cancer strategies should be designed to selectively target CSCs and modulate the hypoxic and acidic tumor microenvironment, and, to this end, natural bioactive components seem to play a role. This review aims to discuss the effects elicited by plant-derived bioactive nutrients in the regulation of CSC self-renewal, cancer metabolism and tumor microenvironment. © 2014 Elsevier Ltd.
Carrera M.,Autonomous University of the State of Morelos |
Carrera M.,National Autonomous University of Mexico |
Gorin T.,University of Guadalajara |
Seligman T.H.,National Autonomous University of Mexico |
Seligman T.H.,International University of Mexico
Physical Review A - Atomic, Molecular, and Optical Physics | Year: 2014
This paper describes the dynamics of a quantum two-level system (qubit) under the influence of an environment modeled by an ensemble of random matrices. In distinction to earlier work, we consider here separable couplings and focus on a regime where the decoherence time is of the same order of magnitude as the environmental Heisenberg time. We derive an analytical expression in the linear response approximation, and study its accuracy by comparison with numerical simulations. We discuss a series of unusual properties, such as purity oscillations, strong signatures of spectral correlations (in the environment Hamiltonian), memory effects, and symmetry-breaking equilibrium states. © 2014 American Physical Society.
Pineda C.,National Autonomous University of Mexico |
Seligman T.H.,National Autonomous University of Mexico |
Seligman T.H.,International University of Mexico
Journal of Physics A: Mathematical and Theoretical | Year: 2015
We present and compare two families of ensembles of random density matrices. The first, static ensemble, is obtained foliating an unbiased ensemble of density matrices. As criterion we use fixed purity as the simplest example of a useful convex function. The second, dynamic ensemble, is inspired in random matrix models for decoherence where one evolves a separable pure state with a random Hamiltonian until a given value of purity in the central system is achieved. Several families of Hamiltonians, adequate for different physical situations, are studied. We focus on a two qubit central system, and obtain exact expressions for the static case. The ensemble displays a peak around Werner-like states, modulated by nodes on the degeneracies of the density matrices. For moderate and strong interactions good agreement between the static and the dynamic ensembles is found. Even in a model where one qubit does not interact with the environment excellent agreement is found, but only if there is maximal entanglement with the interacting one. The discussion is started recalling similar considerations for scattering theory. At the end, we comment on the reach of the results for other convex functions of the density matrix, and exemplify the situation with the von Neumann entropy. © 2015 IOP Publishing Ltd.
Suarez-Cerda J.,Tijuana Institute of Technology |
Nunez G.A.,National Autonomous University of Mexico |
Espinoza-Gomez H.,International University of Mexico |
Flores-Lopez L.Z.,Tijuana Institute of Technology
Materials Science and Engineering C | Year: 2014
This paper describes the effect of different types of cyclodextrins (CDs) in the synthesis of silver nanoparticles (Ag-NPs), using an easy green chemistry method. The Ag-NPs were obtained using an aqueous silver nitrate solution (AgNO3) with α-, β-, or γ-CDs (aqueous solutions) as stabilizing agents, employing the chemical reduction method with citric acid as a reducing agent. A comparative study was done to determine which cyclodextrin (CD) was the best stabilizing agent, and we found out that β-CD was the best due to the number of glucopyranose units in its structure. The formation of the Ag-NPs was demonstrated by analysis of UV-vis spectroscopy, atomic force microscopy (AFM), scanning electron microscopy-energy dispersive spectroscopy (SEM-EDS) and transmission electron microscopy (TEM). SEM-EDS showed the formation of a cluster with a significant amount of silver, for β-CD-Ag-NPs, spherical agglomerates can be observed. However, for α-, γ-CD, the agglomerates do not have a specific form, but their appearance is porous. TEM analysis shows spherical nanoparticles in shape and size between ∼ 0.5 to 7 nm. The clear lattice fringes in TEM images and the typical selected area electron diffraction (SAED) pattern, showed that the Ag-NPs obtained were highly crystalline with a face cubic center structure (FCC). © 2014 Elsevier B.V.
Alvarez-Martinez R.,CINVESTAV |
Alvarez-Martinez R.,National Autonomous University of Mexico |
Cocho G.,National Autonomous University of Mexico |
Rodriguez R.F.,National Autonomous University of Mexico |
And 2 more authors.
Physica A: Statistical Mechanics and its Applications | Year: 2014
Master equations for the evolution of complex networks with positive (birth) and negative (death) transition probabilities per unit time are analyzed. Explicit equations for the time evolution of the total number of nodes and for the relative node frequencies are given. It is shown that, in the continuous limit, the master equation reduces to a Fokker-Planck equation (FPE). The basic dynamical function for its stationary solution is the ratio between its drift and diffusion coefficients. When this ratio is approximated by partial fractions (Padé's approximants), a hierarchy of stationary solutions of the FPE is obtained analytically, which are expressed as an exponential times the product of powers of monomials and binomials. It is also shown that if the difference between birth and death transition probabilities goes asymptotically to zero, the exponential factor in the solution is absent. Fits to real complex network probability distribution functions are shown. Comparison with rank-ordered data shows that, in general, the value of this exponential factor is close to unity, evidencing crossovers among power-law scale invariant regimes which might be associated to an underlying criticality and are related to a generalization of the beta distribution. The time dependent solution is also obtained analytically in terms of hyper-geometric functions. It is also shown that the FPE has similarity solutions. The limitations of the approach here presented are also discussed. © 2014 Elsevier B.V. All rights reserved.
Platt J.J.,International University of Mexico
Journal of Marital and Family Therapy | Year: 2013
Topics such as national identity, patriotism, nationalism, and international issues often lead to polarization within the United States and as a result, critical dialogue about these complex topics often does not occur in a meaningful way. The lack of critical inquiry and interaction about these topics is manifest at the macro and the micro level, including within the context of marriage and family therapy training and practice. While the field of MFT has devoted greater attention to addressing issues of diversity in recent years, limited attention has been focused on examining nationality and nationalism. This article presents a critical patriotism framework that training programs can use to examine nationality and expand awareness of international issues and perspectives. Special attention is focused on examining how nationalism, a problematic extreme version of patriotism, infiltrates MFT training and practice. Recommendations are provided for how training programs can focus on nationality, expand awareness of international issues and perspectives, and guide trainees in exploring how their national identity, beliefs about patriotism, and nationalistic attitudes may influence their clinical work. © 2013 American Association for Marriage and Family Therapy.