Time filter

Source Type

Chinju, South Korea

International University of Korea is a private university located in Jinju, South Korea. It is located 5 miles east of Jinju.Established in 1978 and later as Jinjun International University, the post secondary institution was renamed the current named in 2008.The university is made up of seven colleges and 27 departments with total enrollment at 5,000.IUK offers studies in Korean and English attracting mostly students from Asia as well as from Australia, Canada, United States and Turkey. Wikipedia.

Do M.T.,Chungnam National University | Hwang Y.P.,Chungnam National University | Hwang Y.P.,International University of Korea | Kim H.G.,Chungnam National University | And 2 more authors.
Journal of Cellular Physiology

Mollugin is a naphthohydroquine found in the roots of Rubia cordifolia, and has been reported to have a variety of biological activities, including anti-inflammatory and apoptotic effects. In the present study, we investigated the molecular mechanisms by which mollugin exerts anti-tumor effect in HER2-overexpressing cancer cells. Our results showed that mollugin exhibited potent inhibitory effects on cancer cell proliferation, especially in HER2-overexpressing SK-BR-3 human breast cancer cells and SK-OV-3 human ovarian cancer cells in a dose- and time-dependent manner without affecting immortalized normal mammary epithelial cell line MCF-10A. Furthermore, we found that a blockade of Akt/SREBP-1c signaling through mollugin treatment significantly reduced FAS expression and subsequently suppressed cell proliferation and induced apoptosis in HER2-overexpressing cancer cells. Mollugin treatment caused a dose-dependent inhibition of HER2 gene expression at the transcriptional level, potentially in part through suppression of NF-κB activation. The combination of mollugin with a MEK1/2 inhibitor may be required in order to achieve optimal efficacy in HER2-overexpressing cancers. These data provide evidence that mollugin inhibits proliferation and induces apoptosis in HER2-overexpressing cancer cells by blocking expression of the FAS gene through modulation of a HER2/Akt/SREBP-1c signaling pathway. Our findings suggest that mollugin is a novel modulator of the HER2 pathway in HER2-overexpressing cancer cells with a potential role in the treatment and prevention of human breast and ovarian cancer with HER2 overexpression. J. Cell. Physiol. © 2012 Wiley Periodicals, Inc. Source

Bae S.-H.,Cheongam College | Kim G.-D.,International University of Korea | Kim K.-Y.,Dongshin University
Tohoku Journal of Experimental Medicine

Pain that occurs after a stroke lowers the quality of life. Such post-stroke pain is caused in part by the brain lesion itself, called central post-stroke pain. We investigated the analgesic effects of transcranial direct current stimulation (tDCS) in stroke patients through quantitative sensory testing. Fourteen participants with central post-stroke pain (7 female and 7 male subjects) were recruited and were allocated to either tDCS (n = 7) or sham-tDCS (n = 7) group. Their ages ranged from 45 to 55 years. tDCS was administered for 20 min at a 2-mA current intensity, with anodal stimulations were performed at primary motor cortex. The sham-tDCS group was stimulated 30-second current carrying time. Both group interventions were given for 3 days per week, for a period of 3 weeks. Subjective pain was measured using the visual analogue scale (VAS) of 0 to 10. Sensations of cold and warmth, and pain from cold and heat were quantified to examine analgesic effects. The sham-tDCS group showed no statistically significant differences in time. In contrast, tDCS group showed decreased VAS scores and skin temperature (p < 0.05). The threshold temperatures for the sense of cold and pain from cold increased (p < 0.05), and those for the sense of warmth and pain from heat decreased (p < 0.05). Our findings indicate that tDCS improved sensory identification and exerted analgesic effects in the stroke patients with central post-stroke pain. © 2014 Tohoku University Medical Press. Source

Park B.-S.,International University of Korea | Kim W.Y.,Kyungpook National University | Yoon K.-B.,Kyungpook National University
Korean Journal of Chemical Engineering

Coumarin was reacted with polyamic acid to form a luminous polyimide that is highly soluble in organic solvents and displays good thermal stability. Luminous side-chain coumarin 6 polyimide was obtained from incorporation of sulfonated coumarin 6 into polyamic acid. This polymer appeared in reddish brown solids and unusually exhibited a fairly strong visible light-emission of a yellowish green color. Fluorescence image patterning of side-chain coumarin 6 polyimide was successfully conducted by microtransfer molding of the polyamic acid and the subsequent thermal treatment for imidization. The polyimides exhibit high fluorescence, opening the possibility of new applications for these polymers. © 2013 Korean Institute of Chemical Engineers, Seoul, Korea. Source

Park B.-S.,International University of Korea | Song J.C.,Kyungpook National University | Park D.H.,Kyungpook National University | Yoon K.-B.,Kyungpook National University
Journal of Applied Polymer Science

Melt blending of polylactic acid (PLA) and a chain-extended polyethylene glycol (CE-PEG) have been performed in an effort to toughen the PLA without significant loss of modulus and ultimate tensile strength. The chain-extended PEG was prepared with melt condensation of a low molecular weight PEG and 4,4′-methylenebis(phenylisocyanate) (MDI) for enhancement of the molecular weight of PEG. The thermal and mechanical properties, miscibility and phase morphologies of blends were investigated. By using thermal and fracture surface analysis, the blends were found to be a partially miscible system with shifted glass transition temperatures. The addition of CE-PEG leads to slight decrease in tensile strength and modulus, while the elongation at break is characterized by an important increase (540%), compared with neat PLA and PLA/PEG (low molecular weight PEG, M n = 35,000). The relative ductility of PLA/CE-PEG is 40 times higher than that of neat PLA. The brittle fracture of neat PLA was transformed into a ductile fracture by the addition of CE-PEG. © 2011 Wiley Periodicals, Inc. Source

Lee Y.H.,International University of Korea
Ocean and Polar Research

The Korean Government is trying to construct an ocean research station in Dokdo's water. The station would be the third ocean research station following the Ieodo station and the Gageocho station. Although the new station would served as a scientific research base for peaceful and academic purposes, the construction of the station will almost certainly lead to a diplomatic dispute between Japan and Korea in the near future due to the disputed ownership of the island. In light of the diplomatic protests against the construction of the Ieodo station by the Chinese Government, various domestic and international legal issues which could be raised regarding the construction of the Dokdo station need to be reviewed. Therefore, this article reviews the international legal status of the station and the rights and duties pertaining to its construction, investigates the domestic legal grounds relating to the construction and operation of the marine scientific installation, evaluates the international legal impacts of the construction on the expansion of maritime jurisdiction, the effective control on Dokdo and the negotiations on maritime boundary delimitation, and finally draws conclusions on the future activities of the Korean Government for the construction and operation of the Dokdo Ocean Research Station. Source

Discover hidden collaborations