International Scientific Production Holding Fitokhimiya

Karagandy, Kazakhstan

International Scientific Production Holding Fitokhimiya

Karagandy, Kazakhstan
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Shul'ts E.E.,RAS Institute of Organic Chemistry | Patrushev S.S.,Novosibirsk State University | Belovodskii A.V.,RAS Institute of Organic Chemistry | Shakirov M.M.,RAS Institute of Organic Chemistry | And 5 more authors.
Chemistry of Natural Compounds | Year: 2012

13-Aryl-substituted tourneforin derivatives were synthesized via the Heck reaction with aryliodides. The structure of (E)-13-(3,4-dimethoxybenzyl)-eudesma-4(5),11(13)-dien-6 α,12-olide was confirmed by an XSA. A study of the cytotoxicity of the synthesized derivatives for CEM-13, MT-4, and U-937 tumor models showed promise for the modification. © 2012 Springer Science+Business Media, Inc.


Shul'ts E.E.,RAS Institute of Organic Chemistry | Patrushev S.S.,RAS Institute of Organic Chemistry | Belovodskii A.V.,RAS Institute of Organic Chemistry | Shakirov M.M.,RAS Institute of Organic Chemistry | And 5 more authors.
Chemistry of Natural Compounds | Year: 2012

13-Aryl-substituted tourneforin derivatives were synthesized via the Heck reaction with aryliodides. The structure of (E)-13-(3,4-dimethoxybenzyl)- eudesma-4(5),11(13)-dien-6α,12-olide was confirmed by an XSA. A study of the cytotoxicity of the synthesized derivatives for CEM-13, MT-4, and U-937 tumor models showed promise for the modification. © 2012 Springer Science+Business Media, Inc.


Adekenov S.M.,International Scientific Production Holding Fitokhimiya
Chemistry of Natural Compounds | Year: 2013

New derivatives with hydroxyl, amino, and keto groups; halides; and N atoms were synthesized based on available guaiane-type sesquiterpene lactones arglabin, artefin, ludartin, and estafiatin isolated from yarrow and wormwood. The structures of the molecules were established using IR, UV, PMR, and 13C NMR spectral data. The molecular structures of 2, 6, 12, and 14 were proved by x-ray crystal structure analyses. © 2013 Springer Science+Business Media New York.


Kulakov I.V.,Institute of Organic Synthesis and Carbon Chemistry | Nurkenov O.A.,Institute of Organic Synthesis and Carbon Chemistry | Turdybekov D.M.,International Scientific Production Holding Fitokhimiya | Turdybekov K.M.,International Scientific Production Holding Fitokhimiya
Chemistry of Natural Compounds | Year: 2010

Allylthiourea derivatives were synthesized from the alkaloids cytisine and anabasine and allylisothiocyanate. 1,3-Thiazoline derivatives were synthesized from them via intramolecular heterocyclization using HCl and heating in a sealed ampul. The structures of the synthesized compounds were proved by IR and PMR spectroscopy, mass spectrometry, and x-ray structure analysis. © 2010 Springer Science+Business Media, Inc.

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