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Tsao C.-C.,Sudan University of Science and Technology | Wu W.-W.,International Science and Technology University
International Journal of Computer Integrated Manufacturing | Year: 2014

In highly competitive manufacturing technologies nowadays, delamination-free hole is expected for composite components using innovative designed tools and optimised drilling parameters due to increase in composite structure production and in the need for higher quality machining. An empirical study successfully applies the proposed fuzzy decision-making trial and evaluation laboratory (DEMATEL) to understand the causal influence of the various tool materials and geometries, as well as machining parameters, in drilling composites using compound special-core drill. The obtained result shows that feed rate is the most important factor in innovative project of tool research and design within the cause group. However, cutting velocity ratio, thickness of outer drill, stretch and grit size of diamond have the best effect on machined parameter selection during drilling composites using compound special-core drills. © 2014 © 2014 Taylor & Francis.

Lazakis I.,University of Strathclyde | Turan O.,University of Strathclyde | Aksu S.,International Science and Technology University
Ships and Offshore Structures | Year: 2010

Ship maintenance was initially considered as more of a financial burden than as a way to preserve safety, environment and quality transportation. The benefits from applying a sound and systematic maintenance policy are emerging both in the minimisation of unnecessary downtime as well as in the increase of operational capability. In this paper, a novel predictive maintenance strategy is demonstrated, combining the existing ship operational and maintenance tasks with the advances stemming from new applied techniques. The initial step for the application of the above-mentioned strategy is also shown regarding the machinery space of a cruise ship. Well-known tools are applied such as Failure Modes, Effects and Criticality Analysis (FMECA) and Fault Tree Analysis (FTA). Outcomes of this study are the identification of the critical components of the system, the estimation of the reliability of the overall system and sub-systems, the prioritisation of the maintenance tasks and finally the availability of the specific end events/items. © 2010 Taylor & Francis.

Viju N.,International Science and Technology University | Satheesh S.,International Science and Technology University | Satheesh S.,King Abdulaziz University | Vincent S.G.P.,International Science and Technology University
Saudi Journal of Biological Sciences | Year: 2013

In this study, antibiofilm activity of coconut husk extract (CHE) was tested by various assays in the laboratory. The effects of CHE on extracellular polymeric substance (EPS) production, hydrophobicity and adhesion ability of Pseudomonas sp., Alteromonas sp. and Gallionella sp. and the antimicrobial activity of the extract against these bacteria were assessed. CHE was found to possess antibacterial activity against all the bacterial strains and affected the EPS production. The CHE affected the growth of the biofilm-forming bacteria in a culture medium. The hydrophobicity of the bacterial cells was also changed due to the CHE treatment. The active compound of the CHE was characterised by thin-layer chromatography (TLC), high performance liquid chromatography (HPLC) and fourier transform infrared (FT-IR) analysis. HPLC spectrum showed a single peak and the FT-IR spectrum indicated the presence of an OH-group-containing compound in the extract. In conclusion the CHE could be used as a source for the isolation of antifouling compounds. © 2012.

Zander R.A.,The University of Oklahoma Health Sciences Center | Obeng-Adjei N.,National Institute of Allergy and Infectious Diseases | Guthmiller J.J.,The University of Oklahoma Health Sciences Center | Kulu D.I.,The University of Oklahoma Health Sciences Center | And 5 more authors.
Cell Host and Microbe | Year: 2015

The differentiation and protective capacity of Plasmodium-specific T cells are regulated by both positive and negative signals during malaria, but the molecular and cellular details remain poorly defined. Here we show that malaria patients and Plasmodium-infected rodents exhibit atypical expression of the co-stimulatory receptor OX40 on CD4 T cells and that therapeutic enhancement of OX40 signaling enhances helper CD4 T cell activity, humoral immunity, and parasite clearance in rodents. However, these beneficial effects of OX40 signaling are abrogated following coordinate blockade of PD-1 co-inhibitory pathways, which are also upregulated during malaria and associated with elevated parasitemia. Co-administration of biologics blocking PD-1 and promoting OX40 signaling induces excessive interferon-gamma that directly limits helper T cell-mediated support of humoral immunity and decreases parasite control. Our results show that targeting OX40 can enhance Plasmodium control and that crosstalk between co-inhibitory and co-stimulatory pathways in pathogen-specific CD4 T cells can impact pathogen clearance. © 2015 Elsevier Inc.

Cabuk S.,Cukurova University | Tanrikulu C.,International Science and Technology University | Gelibolu L.,Kafkas University
International Journal of Consumer Studies | Year: 2014

The aim of this research was to examine the effect of health consciousness, environmental concern and food safety concern on both the intention to buy organic foods and the attitude towards organic foods, and the effect of attitude towards organic foods on the intention to buy organic foods. It had also a specific aim to explore whether attitude has a mediation effect on the relationship between the intention to buy and health consciousness, environmental concern and food safety concern. Data were gathered from consumers using a survey. The questionnaire used was administered to a convenience sample of 385 consumers from Adana, Turkey, through a self-administered questionnaire. Regression and mediation analysis were used to test the hypotheses. The findings suggested that the attitude and the intention to buy were affected by health consciousness, environmental concern and food safety concern. They also showed that the attitude plays a fundamental role both in terms of the direct impact on the intention to buy and the indirect effect as a mediator on how the health consciousness, environmental concern and food safety concern affect the intention to buy. This research is useful to fill the gaps in the literature regarding the mediation effect of the attitude on the relationship between the intention to buy and food safety concern. Another contribution is being one of the first to examine the attitude as a mediator on the relationship between the intention to buy organic foods and health consciousness, environmental concern and food safety concern of Turkish consumers. © 2014 John Wiley & Sons Ltd.

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