Cicenas J.,University of Bern |
Cicenas J.,Vilnius University |
Cicenas J.,International School of Law and Business |
Kvederaviciute K.,Vilnius University |
And 3 more authors.
Cancers | Year: 2017
Pancreatic cancer is a disease that has a very high fatality rate and one of the highest mortality ratios among all major cancers, remaining the fourth leading cause of cancer-related deaths in developed countries. The major treatment of pancreatic cancer is surgery; however, only 15–20% of patients are candidates for it at the diagnosis of disease. On the other hand, survival in patients, who undergo surgery, is less than 30%. In most cancers, genome stability is disturbed and pancreatic cancer is not the exception. Approximately 97% of pancreatic cancers have gene derangements, defined by point mutations, amplifications, deletions, translocations, and inversions. This review describes the most frequent genetic alterations found in pancreatic cancer. © 2017 by the authors. Licensee MDPI, Basel, Switzerland.
Vasiliauskas A.V.,Vilnius Gediminas Technical University |
Vilkelis A.,Vilnius Gediminas Technical University |
Zinkeviciute V.,International School of Law and Business |
Batarliene N.,Vilnius Gediminas Technical University
Transport | Year: 2010
The days when a buyer was forced to choose from what is being offered have passed. These days, buyers demand a product that would answer their exclusive expectations at a time of their preference and at an acceptable price. Therefore, manufacturers aiming to survive the competition battle have to rethink their operation strategies. Special importance is attached to the process of development and reconstruction of supply chains, and the process which may feature particularities, depending on the branch of industry. Automobile manufacturing is the biggest the fastest industry developing across the globe. New automobiles are listed as luxury commodities and are, therefore, subjected to very strict requirements with regard to various logistic operations and technologies, which are vital for ensuring efficient automobile delivery to the final users. Due to the growing demand for brand-new automobiles and the distance to the user, automobile manufacturers are constantly searching for solutions to the development and support of an efficient distribution network. Strategy shaping of distribution network requires evaluation of a number of criteria, which influence the distribution system. The article analyzes the development of automobile distribution networks on the basis of multi-criteria evaluation of distribution channels.
Vitkunas R.,International School of Law and Business |
Meidute I.,Vilnius Gediminas Technical University
Transport | Year: 2011
The segment of transport is a significant part of social and economic infrastructure and has a direct impact on certain economic or social territory development. It is known that production and/or trading scale development in a specific territory leads to increased requirements for infrastructure as well as to arising environmental protection issues. Therefore, this paper addresses a very significant problem of constantly increasing vehicle numbers that decrease the permeability of roads and increase traffic jams, which consequently, have an impact on the pollution of the environment. The main goal of this paper is to evaluate bypasses and high-speed streets based on data on Vilnius City using the multi-criteria evaluation method and to verify the hypothesis of the authors. Copyright © 2011 Vilnius Gediminas Technical University (VGTU) Press Technika.
PubMed | Value Innovation, George Washington University, International School of Law and Business and Gregory W. Daniel is managing director for evidence development and innovation at the Engelberg Center for Health Care Reform at Brookings
Type: Journal Article | Journal: Health affairs (Project Hope) | Year: 2015
Multidrug-resistant bacterial diseases pose serious and growing threats to human health. While innovation is important to all areas of health research, it is uniquely important in antibiotics. Resistance destroys the fruit of prior research, making it necessary to constantly innovate to avoid falling back into a pre-antibiotic era. But investment is declining in antibiotics, driven by competition from older antibiotics, the cost and uncertainty of the development process, and limited reimbursement incentives. Good public health practices curb inappropriate antibiotic use, making return on investment challenging in payment systems based on sales volume. We assess the impact of recent initiatives to improve antibiotic innovation, reflecting experience with all sixty-seven new molecular entity antibiotics approved by the Food and Drug Administration since 1980. Our analysis incorporates data and insights derived from several multistakeholder initiatives under way involving governments and the private sector on both sides of the Atlantic. We propose three specific reforms that could revitalize innovations that protect public health, while promoting long-term sustainability: increased incentives for antibiotic research and development, surveillance, and stewardship; greater targeting of incentives to high-priority public health needs, including reimbursement that is delinked from volume of drug use; and enhanced global collaboration, including a global treaty.
Tamburrini G.,International School of Law and Business |
Butakov S.,Concordia University College of Alberta
Journal of International Commercial Law and Technology | Year: 2014
IParadigms, a company involved in plagiarism detection, was hold not liable for the unauthorized use and archival of students' papers. Both the District and Appellate Courts of Virginia, in fact, maintained that the exception of fair use applied to the copyright infringement action. As the relevant facts represent a novelty in case law, it might plausible the hypothesis that iParadigms precedent is not going to be followed in forthcoming cases. This investigation is an attempt to appreciate the possibilities that such an event could happen. In particular, the attention is focused on the special nature of the Copyright Act which is simultaneously backed by opposite theoretical backgrounds such as utilitarianism and moral desert as well as personhood theories, among others. The prevailing of one theory over another shall depend on how liberally or strictly the fair use doctrine shall be interpreted. Despite findings demonstrate judges have applied the fair use doctrine according to the correct conceptions of justice, the discussion ends up recommending a new system of plagiarism detection that drastically reduces the likelihood of copyright infringement actions. © 2014 This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works.
St Inwinkl P.B.,International School of Law and Business |
Rosenberg J.,Jonkoping International Business School
European Energy and Environmental Law Review | Year: 2011
The Swedish government encourages the development of electricity produced from renewable sources using an electricity certificates system. The system is regulated in the Swedish Electricity Certificates Act (lag (2003:113) om elcertifikat). The regulation imposes a penalty fee on producers for those that have received certificates grounded on incorrect or misleading information. Once the penalty fee has been charged, the legislation does not allow any adjustments, even in the case of an unjustified penalty. This article addresses the question whether this scheme is compatible with art. 6 of the European Convention on Human Rights (the Convention). It is concluded that the penalty fee how it is regulated in the Electricity Certificates Act is not in conformity with the Convention and therefore does not comply with EU law. Regulatory changes are needed in the sense that the Electricity Certificates Act has to take into account any reasons for reducing a penalty fee.
Daubariene J.,Vilnius University |
Valiuskevicius G.,Vilnius University |
Asijaviciute V.,International School of Law and Business
8th International Conference on Environmental Engineering, ICEE 2011 | Year: 2011
Functional usage of lakes is the usage of lake shores and water area in order to meet different needs of people. A lot of factors influence the suitability of a lake for certain activities, i.e. geographical position of a lake, water quality, legal regulations, morphometric indexes of lakes etc. The aim of this research is to investigate which morphometric characteristics have impact on the possibilities of functional usage of a lake. The following morphometric parameters have been analysed in this research: lake area, average and maximum depth, the length and indentation of a shoreline, the number of islands and water capacity. This research will also investigate which of these morphometric parameters mostly influences and how it influences such areas of usage of lakes as fishery and fishing, navigations, water supply for people and industry, hydroenergetics and recreation. The object of the research is all Lithuanian lakes bigger than 0.5 ha (total 2,835 lakes). Based on the research of various scientists and legal acts, it was determined which morphometric parameters have the biggest influence on the usage of lakes in a specific area. After grouping the lakes according to the value of morphometric parameters the number of Lithuanian lakes which can perform specific functions was found out. It was established that the functional use of a lake mainly depends on the area of a lake. This directly and indirectly determines the possibilities of a lake usage in all the areas investigated. © Vilnius Gediminas Technical University, 2011.
Buracas A.,International School of Management |
Zvirblis A.,International School of Law and Business |
Joksiene I.,International School of Law and Business
Engineering Economics | Year: 2012
The technique supposes the following procedures: the identification of essential primary macro factors, their quantifiable assessment (in points) as primary criteria allowing the different weights of the impact on economic competitiveness and the composition of task pillars. When examining the primary macro factors, the indicators of global country’s competitiveness index established by the World Economic Forum were taken into account. The whole of the typical primary macrofactors selected by three task pillars (those of specific business infrastructure, common economic surroundings, fiscal and monetary policy macrofactors) is presented. The favorability indexes of each pillar (as partially integrated criteria having different significance) and, in its turn, the generalized measure – macro surroundings favorability index have been determined by applying, in particular, Simple Additive Weighting method.Lithuania‘s macro surrounding advantages were evaluated according to the proposed technique: they may be scored at 54 point (in 100 point system).The economic development in the newly EU countries is oriented to the restructuring of economy also reduction of the differences in the economic development level of various regions. The enlargement of country’s competitive ability and creation of a modern knowledge-based economy are the priorities of the development.This paper concerns the measurement backgrounds of entrepreneurship macro surrounding advantages as a country’s economic competitiveness determinant that applicable for reasoning of the attitudes and decisions of economic development strategy using multi-attribute decision making methods. In principle, the assumption is made that the measurement must be performed according to the approach to every key determinant as a partial economic competitiveness which is subject of essential primary competitiveness macro factors. The conceptual provisions are foremost focused on the measurement of a totality of the national macro surrounding advantages based on the generalized model which reflects the interdependencies of primary macro factors in a system with account of the impact (vector) of each of them. This study is intended to reveal the deterministic measurement possibilities oriented to the reasoned multiple criteria evaluation methods on the basis adopted for the particular task models. © 2012, Kauno Technologijos Universitetas. All rights reserved.
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Dstytojams PASTABADL PRISIJUNGIMO PRIEDSTYTOJO PUSLAPIO!!! Jeigu negalite prisijungti prie Dstytojo puslapio, prisijungimo lange pasirinkite funkcij Slaptaodio priminimas. pasirodiusi slaptaodio priminimo formpakanka rayti tik savo el ...