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Saboktakin M.R.,International Research Institute of Arian Chemie Gostar | Saboktakin M.R.,Baku State University | Tabatabaie R.M.,International Research Institute of Arian Chemie Gostar | Maharramov A.,Baku State University | Ramazanov M.A.,Baku State University
Composites Part B: Engineering | Year: 2011

Hybrid materials, which consist of organic-inorganic materials, are of profound interest owing to their unexpected synergistically derived properties. Aluminium oxide (Al2O3) nanoparticles/polymer composites have been produced using a one-system polymer synthesis. The linear polymer, poly(methyl methacrylate) (PMMA, MW = 15,000 g/mol) and polymethacrylic acid (PMAA) are applied for the stabilization of Al 2O3 nanoparticles. The Fourier transfer infrared (FT-IR) analysis data and scanning electron microscopy (SEM) image reveal that the core shell structure of Al2O3/PMMA/PMAA nanocomposites have been synthesized. The ratio of concentration of the capping polymer material to the concentration of the Al2O3 precursor could control the size of Al2O3 nanoparticles. With specific concentration of the reductant, the core-shell nanostructure could be fluctuated in order. © 2011 Elsevier Ltd. All rights reserved.


Saboktakin M.R.,International Research Institute of Arian Chemie Gostar | Saboktakin M.R.,Baku State University | Tabatabaee R.M.,International Research Institute of Arian Chemie Gostar | Maharramov A.,Baku State University | Ramazanov M.A.,Baku State University
Carbohydrate Polymers | Year: 2010

The main objective of this research is to design a new extended release multiparticulate delivery system by incorporation into nanoparticles made of chitosan-polymethacrylic acid copolymers. As the first part of a continued research on conversion of chitosan to useful biopolymer-based materials, by grafting polymethacrylic acid (PMAA), free radical graft copolymerization was carried out at 70 °C, with bis-acrylamide as a cross-linking agent and persulfate as an initiator. Equilibrium swelling studies were carried out in enzyme-free simulated gastric and intestinal fluids. Also, the paclitaxel as a model drug was entrapped in these nano-gels and in vitro release profiles were established separately in both enzyme-free SGF and SIF. The drug release was found to be faster in SIF. © 2010 Elsevier Ltd. All rights reserved.


Saboktakin M.R.,International Research Institute of Arian Chemie Gostar | Saboktakin M.R.,Baku State University | Tabatabaie R.M.,International Research Institute of Arian Chemie Gostar | Maharramov A.,Baku State University | Ramazanov M.A.,Baku State University
International Journal of Biological Macromolecules | Year: 2011

The purpose of this study was to examine chitosan (CS)-carboxymethyl starch (CMS) nanoparticles as drug delivery system to the colon. The 5-aminosalicylic acid (5-ASA) was chosen as model drug molecule. CS-CMS nanoparticles were formulated by a complex coacervation process under mild conditions. The influence of process variables, including the two ionic polymers, on particle size, and nanoparticles entrapment of 5-ASA was studied. In vitro release of 5-ASA was also evaluated, and the integrity of 5-ASA in the release fraction was assessed using sodium dodecyl sulfate-polyacrylamide gel electrophoresis. The release of 5-ASA from nanoparticle was based on the ion-exchange mechanism. The CS-CMS nanoparticles developed based on the modulation of ratio show promise as a system for controlled delivery of drug to the colon. © 2010 Elsevier B.V.


Reza Saboktakin M.,International Research Institute of Arian Chemie Gostar | Reza Saboktakin M.,Baku State University | Tabatabaie R.M.,International Research Institute of Arian Chemie Gostar | Maharramov A.,Baku State University | Ali Ramazanov M.,Baku State University
International Journal of Biological Macromolecules | Year: 2011

The main aim of this research is to study the in vitro photocytotoxicity and cellular uptake of biodegradable polymeric nanoparticles loaded with photosensitizer mTHPP. As the first part of a continued research on conversion of N-sulfonato-N,O-carboxymethylchitosan (NOCCS) to useful biopolymer-based materials, large numbers of carboxylic functional groups were introduced onto NOCCS by grafting with polymethacrylic acid (PMAA). The free radical graft copolymerization was carried out at 70 °C, bis-acrylamide as a cross-linking agent and persulfate as an initiator. These results show that the nanoparticles have high loading capacity and stability. These nanoparticles are suitable as carriers for photodynamic therapy in vivo. © 2011.


Saboktakin M.R.,International Research Institute of Arian Chemie Gostar | Tabatabaie R.M.,International Research Institute of Arian Chemie Gostar | Maharramov A.,Baku State University | Ramazanov M.A.,Baku State University
Carbohydrate Polymers | Year: 2010

A new synthetic macromolecule, aminodextran-coated iron oxide nanoparticles, was synthesized as drug carrier detectable using magnetic resonance imaging (MRI) technique. The synthesis process starts with a 2-step reaction that attaches a high density of amino groups to a dextran backbone. These macromolecules were coated with magnetic iron oxide molecules by a chemical reaction that can carry several molecules such as drug and peptides. The aminodextran-coated iron oxide nanoparticles thus synthesized have been characterized by Fourier infrared (FT-IR) spectroscopy. Also, the morphology of this synthetic macromolecule was studied by scanning electron microscopy. © 2009 Elsevier Ltd.


Saboktakin M.R.,International Research Institute of Arian Chemie Gostar | Saboktakin M.R.,Baku State University | Tabatabaie R.M.,International Research Institute of Arian Chemie Gostar | Maharramov A.,Baku State University | Ramazanov M.A.,Baku State University
Carbohydrate Polymers | Year: 2010

The main aim of this research is to design a new extended release gastroretentive multiparticulate delivery system by incorporation of the hydrogel beads made of chitosan. As the first part of a continued research on conversion of N-sulfonato-N,O-carboxymethylchitosan(NOCCS) to useful biopolymer-based materials, large numbers of carboxylic functional groups were introduced onto NOCCS by grafting with polymethacrylic acid (PMAA). The free radical graft copolymerization was carried out at 70 °C, bis-acrylamide as a cross-linking agent and persulfate as an initiator. The equilibrium swelling studies were carried out in enzyme-free simulated gastric and intestinal fluids (SGF and SIF, respectively). Also, the satranidazole as a model drug was entrapped in nano-gels and in vitro release profiles were established separately in both enzyme-free SGF and SIF. The drug release was found to be faster in SIF. The drug-release profiles indicate that the drug release depends on their degree of swelling and cross-linking. Crown Copyright © 2010.


Saboktakin M.R.,International Research Institute of Arian Chemie Gostar | Saboktakin M.R.,Baku State University | Tabatabaie R.,International Research Institute of Arian Chemie Gostar | Maharramov A.,Baku State University | Ramazanov M.A.,Baku State University
Carbohydrate Polymers | Year: 2010

The purpose of this study was to examine chitosan (CS)-dextran sulfate (DS) nanoparticles coated iron oxide as drug carriers detectable using magnetic resonance imaging (MRI) technique. The 5-aminosalicylic acid (5-ASA) was chosen as model drug molecule. CS-DS hydrogels were formulated by a complex coacervation process under mild conditions. The influence of process variables, including the two ionic polymers, on particle size, and hydrogel entrapment of 5-ASA was studied. The in vitro release of 5-ASA were also evaluated, and the integrity of 5-ASA in the release fraction was assessed using sodium dodecyl sulfate-polyacrylamide gel electrophoresis. The release of 5-ASA from hydrogel was based on the ion-exchange mechanism. The CS-DS hydrogel developed based on the modulation of ratio show promise as a system for controlled delivery of drug detectable using magnetic resonance imaging (MRI) technique. Crown Copyright © 2010.


Saboktakin M.R.,International Research Institute of Arian Chemie Gostar | Saboktakin M.R.,Baku State University | Tabatabaie R.M.,International Research Institute of Arian Chemie Gostar | Maharramov A.,Baku State University | Ramazanov M.A.,Baku State University
International Journal of Biological Macromolecules | Year: 2011

A novel drug delivery system for the treatment of brain tumors was formulated by methotrexate (MTX)-loaded polymeric nanoparticles (NPs) based on Glycol chitosan (GCS) and Dextran sulfate (DS). The physicochemical properties of resulting particles were investigated, evidencing the contribution of these nanoparticles for brain targeting. In vitro release of MTX was also evaluated. The GCS-DS nanoparticles have been developed based on the modulation of ratio show promise as a system for controlled delivery of the drug to the brain. © 2011 Elsevier B.V.


Saboktakin M.R.,International Research Institute of Arian Chemie Gostar | Saboktakin M.R.,Baku State University | Tabatabaie R.M.,International Research Institute of Arian Chemie Gostar | Maharramov A.,Baku State University | Ramazanov M.A.,Baku State University
International Journal of Biological Macromolecules | Year: 2011

The main objective of this study was to develop a local, oral mucoadhesive metronidazole benzoate (MET) delivery system that can be applied and removed by the patient for the treatment of periodontal diseases. The results of present study revealed that the retention time of MET at its absorption site could be increased by formulating it into nanoparticles using thiolated chitosan (TCS)-poly(methacrylic acid) (PMAA). The nanoparticles of MET prepared from TCS-PMAA may represent a useful approach for targeting its release at its site of absorption, sustaining its release and improving its oral availability. © 2011 Elsevier B.V.


Saboktakin M.R.,International Research Institute of Arian Chemie Gostar | Tabatabaee R.M.,International Research Institute of Arian Chemie Gostar
International Journal of Biological Macromolecules | Year: 2014

Photodynamic therapy (PDT) is a medical treatment in which a combination of a photosensitizing drug and visible light causes destruction of selected cells. Over the past two decades, photodynamic therapy has enjoyed a period of laboratory and in the clinic. Although still widely considered to be an experimental technique, its status and value within modern clinical practice continues to grow. The PDT field has, to date, been dominated by a small number of pharmaceutical companies inhabited almost exclusively by clinicians and those involved in fundamental scientific research. True pharmaceutical formulation development has been limited, to some extent, by financial constraints. If PDT is to realize its undoubted potential in clinical practice it is important that awareness of the need for appropriate photosensitizer delivery systems is raised. Accordingly, this article deals with the innovations pertaining to drug delivery systems for photodynamic therapy as disclosed in recent patent literature. © 2014 Elsevier B.V.

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