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Saboktakin M.R.,International Research Institute of Arian Chemie Gostar | Tabatabaie R.M.,International Research Institute of Arian Chemie Gostar | Maharramov A.,Baku State University | Ramazanov M.A.,Baku State University
Carbohydrate Polymers | Year: 2010

A new synthetic macromolecule, aminodextran-coated iron oxide nanoparticles, was synthesized as drug carrier detectable using magnetic resonance imaging (MRI) technique. The synthesis process starts with a 2-step reaction that attaches a high density of amino groups to a dextran backbone. These macromolecules were coated with magnetic iron oxide molecules by a chemical reaction that can carry several molecules such as drug and peptides. The aminodextran-coated iron oxide nanoparticles thus synthesized have been characterized by Fourier infrared (FT-IR) spectroscopy. Also, the morphology of this synthetic macromolecule was studied by scanning electron microscopy. © 2009 Elsevier Ltd. Source


Saboktakin M.R.,International Research Institute of Arian Chemie Gostar | Saboktakin M.R.,Baku State University | Tabatabaie R.M.,International Research Institute of Arian Chemie Gostar | Maharramov A.,Baku State University | Ramazanov M.A.,Baku State University
Carbohydrate Polymers | Year: 2010

The main aim of this research is to design a new extended release gastroretentive multiparticulate delivery system by incorporation of the hydrogel beads made of chitosan. As the first part of a continued research on conversion of N-sulfonato-N,O-carboxymethylchitosan(NOCCS) to useful biopolymer-based materials, large numbers of carboxylic functional groups were introduced onto NOCCS by grafting with polymethacrylic acid (PMAA). The free radical graft copolymerization was carried out at 70 °C, bis-acrylamide as a cross-linking agent and persulfate as an initiator. The equilibrium swelling studies were carried out in enzyme-free simulated gastric and intestinal fluids (SGF and SIF, respectively). Also, the satranidazole as a model drug was entrapped in nano-gels and in vitro release profiles were established separately in both enzyme-free SGF and SIF. The drug release was found to be faster in SIF. The drug-release profiles indicate that the drug release depends on their degree of swelling and cross-linking. Crown Copyright © 2010. Source


Saboktakin M.R.,International Research Institute of Arian Chemie Gostar | Saboktakin M.R.,Baku State University | Tabatabaie R.M.,International Research Institute of Arian Chemie Gostar | Maharramov A.,Baku State University | Ramazanov M.A.,Baku State University
International Journal of Biological Macromolecules | Year: 2011

A novel drug delivery system for the treatment of brain tumors was formulated by methotrexate (MTX)-loaded polymeric nanoparticles (NPs) based on Glycol chitosan (GCS) and Dextran sulfate (DS). The physicochemical properties of resulting particles were investigated, evidencing the contribution of these nanoparticles for brain targeting. In vitro release of MTX was also evaluated. The GCS-DS nanoparticles have been developed based on the modulation of ratio show promise as a system for controlled delivery of the drug to the brain. © 2011 Elsevier B.V. Source


Saboktakin M.R.,International Research Institute of Arian Chemie Gostar | Saboktakin M.R.,Baku State University | Tabatabaie R.M.,International Research Institute of Arian Chemie Gostar | Maharramov A.,Baku State University | Ramazanov M.A.,Baku State University
International Journal of Biological Macromolecules | Year: 2011

The main objective of this study was to develop a local, oral mucoadhesive metronidazole benzoate (MET) delivery system that can be applied and removed by the patient for the treatment of periodontal diseases. The results of present study revealed that the retention time of MET at its absorption site could be increased by formulating it into nanoparticles using thiolated chitosan (TCS)-poly(methacrylic acid) (PMAA). The nanoparticles of MET prepared from TCS-PMAA may represent a useful approach for targeting its release at its site of absorption, sustaining its release and improving its oral availability. © 2011 Elsevier B.V. Source


Reza Saboktakin M.,International Research Institute of Arian Chemie Gostar | Reza Saboktakin M.,Baku State University | Tabatabaie R.M.,International Research Institute of Arian Chemie Gostar | Maharramov A.,Baku State University | Ali Ramazanov M.,Baku State University
International Journal of Biological Macromolecules | Year: 2011

The main aim of this research is to study the in vitro photocytotoxicity and cellular uptake of biodegradable polymeric nanoparticles loaded with photosensitizer mTHPP. As the first part of a continued research on conversion of N-sulfonato-N,O-carboxymethylchitosan (NOCCS) to useful biopolymer-based materials, large numbers of carboxylic functional groups were introduced onto NOCCS by grafting with polymethacrylic acid (PMAA). The free radical graft copolymerization was carried out at 70 °C, bis-acrylamide as a cross-linking agent and persulfate as an initiator. These results show that the nanoparticles have high loading capacity and stability. These nanoparticles are suitable as carriers for photodynamic therapy in vivo. © 2011. Source

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