Silachev D.N.,A N Belozersky Institute Of Physicochemical Biology |
Plotnikov E.Y.,A N Belozersky Institute Of Physicochemical Biology |
Danilina T.I.,Moscow State University |
Zorov L.D.,International Laser Research Center |
And 2 more authors.
Bulletin of Experimental Biology and Medicine | Year: 2015
We compared the efficiency of delivery of multipotent mesenchymal stem cells into the brain after their intravenous and intra-arterial injection. Analysis of the therapeutic effects of cells after experimental traumatic brain injury revealed improvement of the neurological status and motor functions of the damaged hemisphere, the effect being more pronounced after intraarterial injection of cells. Intra-arterial administration was followed by rapid infiltration of the cells into the brain tissue and their number considerably surpassed that after intravenous infusion. Targeted delivery of multipotent mesenchymal stromal cells into the brain after their injection into the carotid arteries substantially potentiated their neuroprotective effects in traumatic brain injury. © 2015, Springer Science+Business Media New York.