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Li S.,Changchun University of Science and Technology | Li S.,International Joint Research Center for Nanophotonics and Biophotonics | Xu D.,Jilin University | Shen H.,Jilin University | And 3 more authors.
Materials Research Bulletin | Year: 2012

With cetyltrimethylammonium bromide (CTAB) as a soft template, magnesium borate (Mg 2B 2O 5) one-dimensional micro/nanorods were synthesized. The products prepared in the absence of CTAB were Mg 2B 2O 5 nanoparticals and needles. However, using CTAB as a soft template the products were Mg 2B 2O 5 whiskers (diameter: 200 ± 10 nm, length: 1-2 μm). The formation mechanism was discussed. In addition, the experimental and theoretical Raman spectra of Mg 2B 2O 5 were reported for the first time, and the possible vibrations modes of Mg 2B 2O 5 crystals were assigned based on the calculation results. Copyright © 2012 Published by Elsevier Ltd. All rights reserved.


Liu L.-W.,Changchun University of Science and Technology | Liu L.-W.,International Joint Research Center for Nanophotonics and Biophotonics | Hu S.-Y.,Changchun University of Science and Technology | Hu S.-Y.,International Joint Research Center for Nanophotonics and Biophotonics | And 7 more authors.
Beilstein Journal of Nanotechnology | Year: 2014

In this study, we report on CdS/ZnS nanocrystals as a luminescence probe for bioimaging applications. CdS nanocrystals capped with a ZnS shell had enhanced luminescence intensity, stronger stability and exhibited a longer lifetime compared to uncapped CdS. The CdS/ZnS nanocrystals were stabilized in Pluronic F127 block copolymer micelles, offering an optically and colloidally stable contrast agents for in vitro and in vivo imaging. Photostability test exhibited that the ZnS protective shell not only enhances the brightness of the QDs but also improves their stability in a biological environment. An in-vivo imaging study showed that F127- CdS/ZnS micelles had strong luminescence. These results suggest that these nanoparticles have significant advantages for bioimaging applications and may offer a new direction for the early detection of cancer in humans. © 2014 Liu et al.


Liu L.,Changchun University of Science and Technology | Liu L.,State University of New York at Buffalo | Liu L.,International Joint Research Center for Nanophotonics and Biophotonics | Law W.-C.,State University of New York at Buffalo | And 13 more authors.
Analyst | Year: 2011

Recently, multimodal nanoparticles integrating dual- or tri-imaging modalities into a single hybrid nanosystem have attracted plenty of attention in biomedical research. Here, we report the fabrication of two types of multimodal micelle-encapsulated nanoparticles, which were systematically characterized and thoroughly evaluated in terms of their imaging potential and biocompatibility. Optical and magnetic resonance (MR) imaging probes were integrated by conjugating DOTA-gadolinium (Gd) derivative to quantum dot based nanomicelles. Two amphiphilic block copolymer micelles, amine-terminated mPEG-phospholipid and amine-modified Pluronic F127, were chosen as the capping agents because of their excellent biocompatibility and ability to prevent opsonization and prolong circulation time in vivo. Owing to their different hydrophobic-hydrophilic structure, the micellar aggregates exhibited different sizes and protection of core QDs. This work revealed the differences between these nanomicelles in terms of the stability over a wide range of pH, along with their cytotoxicity and the capacity for chelating gadolinium, thus providing a useful guideline for tailor-making multimodal nanoparticles for specific biomedical applications. © 2011 The Royal Society of Chemistry.


Cai H.,International Joint Research Center for Nanophotonics and Biophotonics | Zhu J.,State University of New York at Buffalo | Chen G.,International Joint Research Center for Nanophotonics and Biophotonics | Liu L.,International Joint Research Center for Nanophotonics and Biophotonics | And 2 more authors.
Journal of Raman Spectroscopy | Year: 2011

As an infrared Raman probe, the molecule 3,3′- diethylthiatricarbocyanine iodide (DTTC) has received much attention in the past decades due to its potential applications in Raman imaging, single-cell detection, cancer diagnosis, and surface-enhanced Raman scattering (SERS). In this work, ordinary Raman, SERS, and theoretical Raman spectra were investigated to estimate the DTTC suspension. More specifically, the original gold nanospheres (60 nm diameter) and gold nanorods were encoded with DTTC and stabilized with a layer of thiol-polyethylene glycol as Raman reporter; SERS data were also obtained from the samples. Hartree-Fock theory and density functional theory (DFT) calculation were applied to calculate the optimized Raman spectra of DTTC in water on the B3LYP/6-31G level. Subsequently, the obtained experimental spectra from DTTC were carefully compared with the theoretically calculated spectra, and good agreement was obtained between the theoretical and experimental results.The bands between 500 and 3100 cm -1 in the ordinary Raman and SERS spectra were assigned as well. This work will facilitate the development of ultrasensitive SERS probes for advanced biomedical imaging applications. © 2011 John Wiley & Sons, Ltd.


Liu L.,Changchun University of Science and Technology | Liu L.,State University of New York at Buffalo | Liu L.,International Joint Research Center for Nanophotonics and Biophotonics | Ding H.,State University of New York at Buffalo | And 14 more authors.
Plasmonics | Year: 2011

We report the use of biocompatible gold nanorods (GNRs) as multimodal (plasmonic and magnetic) probes for cancer cell labeling in vitro. These multifunctional and multimodal bioconjugates were prepared by replacing cetyltrimethylammonium bromide with a mixture of functionalized PEGylation molecules so that a variety of functionalities (e.g., magnetic resonance imaging agent gadolinium (Gd) and biorecognition molecule transferrin (Tf)) can be easily integrated using simple chemistry. It was shown that Gd incorporation did not interfere with the plasmonic properties of the GNRs and a strong T1 relaxivity was estimated (10.0 mM-1 s-1), which is more than twice that of the clinical MRI agent Gd-DTPA. The large observed T1 relaxivity was possibly due to the huge surface to volume ratio of GNR, which allowed huge amount of amine-terminated molecule to anchor on the surface, coupled with Gd (III) ions for the enhanced relaxation of water protons. Pancreatic cancer cell overexpressing the transferring receptor was served as the in vitro model, and the Tf-mediated uptake was demonstrated and confirmed by dark-field imaging and transmission electron microscopy. More importantly, cell viability (MTS) assay did not reveal any sign of toxicity in these treated cells, suggesting that PEGylated GNRs can serve as a biocompatible, multifunctional, and multimodal platform for variable bio-applications. © 2010 Springer Science+Business Media, LLC.


Erogbogbo F.,State University of New York at Buffalo | Liu T.,Changchun University of Science and Technology | Liu T.,State University of New York at Buffalo | Liu T.,International Joint Research Center for Nanophotonics and Biophotonics | And 6 more authors.
ACS Nano | Year: 2011

Particle size is widely used to tune the electronic, optical, and catalytic properties of semiconductor nanocrystals. This contrasts with bulk semiconductors, where properties are tuned based on composition, either through doping or through band gap engineering of alloys. Ideally, one would like to control both size and composition of semiconductor nanocrystals. Here, we demonstrate production of silicon-germanium alloy nanoparticles by laser pyrolysis of silane and germane. We have used FTIR, TEM, XRD, EDX, SEM, and TOF-SIMS to conclusively determine their structure and composition. Moreover, we show that upon extended sonication in selected solvents, these bare nanocrystals can be stably dispersed without ligands, thereby providing the possibility of using them as an ink to make patterned films, free of organic surfactants, for device fabrication. The engineering of these SiGe alloy inks is an important step toward the low-cost fabrication of group IV nanocrystal optoelectronic, thermoelectric, and photovoltaic devices. © 2011 American Chemical Society.


Law W.-C.,State University of New York at Buffalo | Law W.-C.,International Joint Research Center for Nanophotonics and Biophotonics | Yong K.-T.,State University of New York at Buffalo | Yong K.-T.,Nanyang Technological University | And 4 more authors.
ACS Nano | Year: 2011

In this study, we report the development of a nanoparticle-enhanced biosensor by integrating both the nanoparticles and immunoassay sensing technologies into a phase interrogation surface plasmon resonance (SPR) system for detecting antigen at a concentration as low as the femtomolar range. Our work has demonstrated that the plasmonic field extension generated from the gold film to gold nanorod (GNR) has led to a drastic sensitivity enhancement. Antibody-functionalized sensing film, together with antibody-conjugated GNRs, was readily served as a plasmonic coupling partner that can be used as a powerful ultrasensitive sandwich immunoassay for cancer-related disease detection. Experimentally, it was found that the bioconjugated GNR labels enhance the tumor necrosis factor alpha (TNF-α) antigen signal with more than 40-fold increase compared to the traditional SPR biosensing technique. The underlying principle was analyzed by simulating the near-field coupling between the sensing film and the GNR. The results have shown that GNRs were readily served as promising amplification labels in SPR sensing technology. © 2011 American Chemical Society.


Liu L.-W.,Changchun University of Science and Technology | Liu L.-W.,International Joint Research Center for Nanophotonics and Biophotonics | Hu S.-Y.,Changchun University of Science and Technology | Hu S.-Y.,International Joint Research Center for Nanophotonics and Biophotonics | And 5 more authors.
Beilstein Journal of Nanotechnology | Year: 2015

This study investigates near-infrared region Ag2S quantum dots (QDs) and their nonlinear optical response under 532 nm nanosecond laser pulses. Our experimental result shows that nonlinear transmission is reduced from 0.084 to 0.04. The observed narrowing behavior of the output pulse width shows superior optical limiting. We discuss the physical mechanisms responsible for the nonlinear optical response of the QDs. The average size of the nanocrystals was 5.5 nm. Our results suggest the possibility of using these Ag2S QDs for photoelectric, biosensor, optical ranging, and self-adaptive technologies. © 2015 Liu et al.


Guo M.-R.,International Joint Research Center for Nanophotonics and Biophotonics | Cai H.-X.,International Joint Research Center for Nanophotonics and Biophotonics | Chen G.,International Joint Research Center for Nanophotonics and Biophotonics | Fan Y.,International Joint Research Center for Nanophotonics and Biophotonics | Zhang X.-H.,International Joint Research Center for Nanophotonics and Biophotonics
Guang Pu Xue Yu Guang Pu Fen Xi/Spectroscopy and Spectral Analysis | Year: 2011

Malachite green isothiocyanate(MGITC)is a Raman probe molecule that was applied to cells detection, tissue composition detection and cells stain imaging. In the present work, MGITC molecular structure was optimized by density functional theory(DFT) calculation. MGITC molecular Raman spectra and infrared spectra were calculated with Hartree-Fork theory and MP2 theory based on STO-3G level, then two theoretical Raman spectra were carefully compared with experimental spectra, and good agreements were obtained between the theoretical and experimental results. MGITC structure parameters were given also in the paper including bond lengths and bond angles etc. Vibrational modes were assigned to all bands in the range between 550 and 4200 cm-1. This work will facilitate the application of MGITC Raman probe for biology.

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