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Chen Z.,China Pharmaceutical University | Chen Z.,Zhejiang Pharmaceutical College | Chen Z.,International Joint Laboratory SYSU PolyU HK of Novel Anti dementia Drugs of Guangdong Province | Digiacomo M.,University of Pisa | And 22 more authors.
European Journal of Medicinal Chemistry | Year: 2017

A series of rivastigmine-caffeic acid and rivastigmine-ferulic acid hybrids were designed, synthesized, and evaluated as multifunctional agents for Alzheimer's disease (AD) in vitro. The new compounds exerted antioxidant neuroprotective properties and good cholinesterases (ChE) inhibitory activities. Some of them also inhibited amyloid protein (Aβ) aggregation. In particular, compound 5 emerged as promising drug candidates endowed with neuroprotective potential, ChE inhibitory, Aβ self-aggregation inhibitory and copper chelation properties. These data suggest that compound 5 offers an attractive starting point for further lead optimization in the drug-discovery process against AD. © 2016 Elsevier Masson SAS

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