International Institute of Biophysics

Neuß, Germany

International Institute of Biophysics

Neuß, Germany
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Lipkind M.,Kimron Veterinary Institute | Lipkind M.,International Institute of Biophysics
Advanced Science Letters | Year: 2010

According to current views, a comprehensive analysis of recordings obtained from neuronal complexes related to any individual's thinking process will permit reading the corresponding individual's thoughts. Yet, consistent reasoning leads to conclusion about the in principle impossibility to read human thoughts on the basis of a however exhaustive resolution of the physical recordings gained from the respective neural networks. © 2010 American Scientific Publishers.


Del Giudice E.,National Institute of Nuclear Physics, Italy | Del Giudice E.,International Institute of Biophysics | Pulselli R.M.,University of Siena
International Journal of Design and Nature and Ecodynamics | Year: 2010

In living systems, water takes part in the dynamics of life, not only because it accounts for 99% of all biomolecules but also because it provides energy to living matter. Water has the ability to achieve an extended form of organization and provide an ensemble of different coherence domains (CDs) that are phase locked, thus maximizing their capacity to 'look for' energy from the environment. This 'coherence of coherences' of 'biological water' in living systems corresponds to a sort of higher organization. An efficient mechanism of energy transformation from CDs to biomolecules in living matter guarantees the transfer of biochemical energy necessary for the maintenance of life cycles. The dynamics of formation of dissipative structures in liquid water and the process of self-organization of living organisms induced by water are briefly discussed. Dissipative structures appear as a consequence of the phase locking within an ensemble of CDs. The process of charge and discharge of energy is discussed. © 2010 WIT Press.


Marchettini N.,University of Siena | Del Giudice E.,National Institute of Nuclear Physics, Italy | Del Giudice E.,International Institute of Biophysics | Voeikov V.,International Institute of Biophysics | And 2 more authors.
Journal of Theoretical Biology | Year: 2010

The Belousov-Zhabotinsky phenomenon is analyzed in a framework where the dynamics of dissipative structures outlined by Prigogine is implemented through the collective dynamics produced in liquid water by Quantum Electrodynamics, which has received recently some experimental support. A mechanism allowing the appearance of self-produced oscillations is suggested. © 2010 Elsevier Ltd.


Van Wijk E.P.A.,Leiden University | Van Wijk E.P.A.,Meluna Research | Van Wijk E.P.A.,International Institute of Biophysics | Wijk R.V.,Meluna Research | And 5 more authors.
Journal of Photochemistry and Photobiology B: Biology | Year: 2010

Photon signals emitted spontaneously from dorsal and palm sides of both hands were recorded using 6000 time windows of size T=50. ms in 50 healthy human subjects. These photon signals demonstrated universal behaviour by variance and mean. The data sets for larger time windows up to T=50. s were obtained by merging the data recorded with T=50. ms. The behaviour of Fano factor regarding different window sizes was investigated. The Fano factor hovered around one in signals up to T=3. s and increased slowly with the increase in window size. This indicated super-Poissonian distribution of photo counts. The Fano factor curve F(T) obtained by averaging all subjects and locations had a characteristic shape. Data suggest that the shape is essentially a combination of a smaller sub-population of individuals with sub-Poissonian and a larger sub-population with predominantly super-Poissonian photo count distribution. Averaging the data obtained by randomly shuffling observed data sets was flat and did not show any structure with T. The same applied both to the observed background data sets and the data sets obtained by randomly shuffling background in 50 measurements. The Fano factor was also flat in 50 measurements documented both by a standard LED as well as its shuffled data sets. The structure in the shape F(T) is characteristic of human signals. It may contain valuable information about metabolic processes and may have diagnostic relevance. © 2010 Elsevier B.V.


Van Wijk R.,International Institute of Biophysics | Van Wijk R.,Meluna Research | Wiegant F.A.C.,University Utrecht
Frontiers in Bioscience - Elite | Year: 2011

Postexposure conditioning, as a part of hormesis, involves the application of a low dose of stress following exposure to a severe stress condition. The beneficial effect of a low level of stress in postconditioning hormesis is illustrated by a number of examples found in experimental and clinical research. Depending on whether the low-dose stress is of the same type of stress or is different from the initial high-dose stress causing the diseased state, postconditioning is classified as homologous or heterologous, respectively. In clinical homeopathy, where substances are applied according to the Similia principle, the same distinction is found between the isopathic and the 'heteropathic' or homeopathic use of low dose substances. The Similia principle implies that substances causing symptoms in healthy biological systems can be used to treat similar symptoms in diseased biological systems. Only when heterologous substances are tested for therapeutic effects, the Similia principle can be studied. It is then possible to compare the effect of treatment with the degree of similarity between the diseased state and the effects caused by different substances. The latter research was mainly performed with cells in culture using heat shocked cells post exposed to a variety of stress conditions in low dose.


Van Wijk E.P.A.,International Institute of Biophysics | Van Wijk E.P.A.,Leiden Amsterdam Center for Drug Research | Van Wijk R.,International Institute of Biophysics | Bosman S.,International Institute of Biophysics
Journal of Photochemistry and Photobiology B: Biology | Year: 2010

Exposure of skin to ultraviolet (UV) radiation triggers oxidative stress in skin tissue that can lead to erythema, early skin aging or even cancer. It is suggested that oligomeric proanthocyanidins (OPCs), phytonutrients that belong to the polyphenol family have an anti-oxidant/anti-inflammatory activity on the skin. Measuring ultra-weak photon emission (UPE) is a non-invasive, fairly-sensitive and convenient technique for continuously monitoring oxidative stress. The present study was undertaken to confirm anti-oxidant activity of the specific OPCs cream formulation in human skin by measuring UPE of skin. In the present study 25 healthy female subjects participated. As a baseline measurement of skin, UPE was recorded from the dorsal surface of the subjects' hands before (spontaneous UPE) and after exposure to UV (UV-induced UPE). The effects of the OPCs cream on spontaneous and UV-induced UPE were measured using a fractionated UV exposure protocol. UV exposure resulted in an increase in UPE from both hands. Repeat UV exposure also resulted in a long-term increase of spontaneous UPE. This is likely due to depletion of anti-oxidant capacity of skin resulting in sensitization of skin to UV. It was assessed by measuring spontaneous UPE at 80 min after each UV exposure. Application of the OPCs cream immediately after UV exposure resulted in a significant (approx. 30%) decrease in UV-induced UPE. Topical OPCs cream application also reduced sensitization of skin to UV following repeated UV exposure (i.e., reduced long-term increase in spontaneous UPE). This study indicates that the specific OPCs cream formulation significantly decreases UV-induced oxidative stress in human skin based on UPE measurement. It therefore suggests that regular use of this OPCs cream might protect skin from harmful effects of UV. © 2010 Elsevier B.V. All rights reserved.


Van Wijk R.,International Institute of Biophysics | Wiegant F.A.C.,University Utrecht
Human and Experimental Toxicology | Year: 2010

Postexposure conditioning, as a part of hormesis, involves the application of a low dose of stress following exposure to a severe stress condition. Depending on whether the low-dose stress is of the same type of stress or is different from the initial high-dose stress causing the diseased state, postconditioning can be classified as homologous or heterologous, respectively. In clinical homeopathy, the same distinction is found between isopathic and homeopathic application of low-dose substances. Homeopathy is unique for its Similia principle, which implies that substances causing symptoms in healthy biological systems can be used to treat similar symptoms in diseased biological systems. The evaluation of the Similia principle in an experimental set-up requires the analysis of a complex sequence of 'damage-disease-treatment-effect' events. The process of recovery from an insult is then monitored and a possible beneficial effect on this recovery process, upon application of a range of substances in low dose, can subsequently be analyzed using molecular and functional parameters. It is then possible to compare the effect of treatment with the degree of similarity between the diseased state and the effects caused by homologous and/or different heterologous substances. Beneficial effects of postconditioning mild stress conditions have been described in terms of an increase of the synthesis of stress proteins. In this commentary paper, we present additional information on this aspect. The experimental data suggest that the beneficial effect of the low-dose stress condition used as heterologous postconditioning is related to similarity in molecular stress response. © The Author(s) 2010.


Wiegant F.,University Utrecht | Van Wijk R.,University Utrecht | Van Wijk R.,International Institute of Biophysics
Homeopathy | Year: 2010

This paper describes the results of a research program focused on the beneficial effect of low dose stress conditions that were applied according to the similia principle to cells previously disturbed by more severe stress conditions. In first instance, we discuss criteria for research on the similia principle at the cellular level. Then, the homologous ('isopathic') approach is reviewed, in which the initial (high dose) stress used to disturb cellular physiology and the subsequent (low dose) stress are identical. Beneficial effects of low dose stress are described in terms of increased cellular survival capacity and at the molecular level as an increase in the synthesis of heat shock proteins (hsps). Both phenomena reflect a stimulation of the endogenous cellular self-recovery capacity. Low dose stress conditions applied in a homologous approach stimulate the synthesis of hsps and enhance survival in comparison with stressed cells that were incubated in the absence of low dose stress conditions. Thirdly, the specificity of the low dose stress condition is described where the initial (high dose) stress is different in nature from the subsequently applied (low dose) stress; the heterologous or 'heteropathic' approach. The results support the similia principle at the cellular level and add to understanding of how low dose stress conditions influence the regulatory processes underlying self-recovery. In addition, the phenomenon of 'symptom aggravation' which is also observed at the cellular level, is discussed in the context of self-recovery. Finally, the difference in efficiency between the homologous and the heterologous approach is discussed; a perspective is indicated for further research; and the relationship between studies on the similia principle and the recently introduced concept of 'postconditioning hormesis' is emphasized. © 2009 The Faculty of Homeopathy.


Wiegant F.A.C.,University Utrecht | Prins H.A.B.,University Utrecht | van Wijk R.,University Utrecht | van Wijk R.,International Institute of Biophysics
Dose-Response | Year: 2011

A beneficial effect of applying mild stress to cells or organisms, that were initially exposed to a high dose of stress, has been referred to as 'postconditioning hormesis'. The initial high dose of stress activates intrinsic self-recovery mechanisms. Modulation of these endogenous adaptation strategies by administration of a subsequent low dose of stress can confer effects that are beneficial to the biological system. Owing to its potentially therapeutic applications, postconditioning hormesis is subject to research in various scientific disciplines. This paper presents an overview of the dynamics of postconditioning hormesis and illustrates this phenomenon with a number of examples in experimental and clinical research. © 2011 University of Massachusetts.


PubMed | International Institute of Biophysics
Type: Journal Article | Journal: Journal of acupuncture and meridian studies | Year: 2010

It has been reported that the colors perceived behind closed eyes provide an indication of the psychophysical state of a subject. We discuss this phenomenon in the light of recently developed approaches to living organisms, based on the interplay between matter organization, biochemistry and electrodynamics. When there is no energy, there is no color, no shape, no life. Caravaggio (1571-1610).

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