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Romano M.,University of Trieste | Buratti E.,International Center for Genetic Engineering An Biotechnology | Romano G.,International Center for Genetic Engineering An Biotechnology | Klima R.,International Center for Genetic Engineering An Biotechnology | And 4 more authors.
Journal of Biological Chemistry | Year: 2014

Background: TDP-43 and hnRNPA1/A2 factors are implicated in neurodegeneration. Results: The human and fruit fly TDP-43 and hnRNPA1/A2 orthologs show physical, genetic, and functional interplays. Conclusion: The functional cooperation between TBPH/Hrp38 and TDP-43/hnRNP A/B is conserved throughout evolution. Significance: TBPH/Hrp38 interplay can be critical for neurodegeneration, and Drosophila is a model suitable to study the impact of this interaction. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.

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