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Rao Dr. G.S.N.,Tagore Medical College and Hospital | Gurumurthy P.,International Center for Cardio Thoracic and Vascular Diseases | Sruti E.,Tagore Medical College and Hospital
International Journal of Pharma and Bio Sciences | Year: 2013

The incidence of obesity among childhood in India is largely increasing. The serum apolipoproteins and its correlation with anthropometric and biochemical parameters were evaluated in 296 school children and adolescents (96 obese, 97 overweight, were compared with 103 normal controls, aged between 10-17 years). Anthropometric variables, lipid profile, fasting serum glucose analyzed by auto- analyzer and serum apolipoproteins by Immunoturbidimetry assay. Serum Apo-AI levels were decreased in obese and overweight children (130.94±9.24mg/dl, 132.26±10.80mg/dl Vs 153.08±17.98mg/dl) (p<0.001) than control children. Serum Apo-B levels were significantly elevated in obese and overweight children (88.54±11.4mg/dl,82.6±12.64mg/dl Vs 73.55±12.03mg/dl) (p<0.001) than controls. Serum Apo-B levels showed positive correlation with BMI, WHR, Apo-B/Apo-AI ratio, TCHR, TC, TG, LDL-C and showed negative correlation with fasting glucose levels, and no association with HDL-C. Serum Apo-AI levels showed negative correlation with BMI, WHR, Apo-B/Apo- AI ratio, TCHR, TC, TG, LDL-C and showed positive correlation with HDL-C and fasting glucose levels. These findings suggest that childhood obesity is associated with abnormal lipid patterns. Prevention campaigns aimed at identifying obese children and reducing their weight would probably also improve the lipid profile.


Vijayalakshmi R.,SRM University | Nayar S.,International Center for Cardio Thoracic and Vascular Diseases | Cherian K.M.,International Center for Cardio Thoracic and Vascular Diseases
American Journal of Infectious Diseases | Year: 2010

Problem statement: The primary aim was to study the expression of CD44 protein in the heart valves removed surgically for either stenosis or regurgitation and to study the morphology of valves using histochemical staining. Approach: We studied 107 valves which were collected from the International Centre for Cardio Thoracic and Vascular Diseases. Results: Aortic and mitral valves were obtained from the centre and processed in research pathology lab. CD44 protein is a receptor for the ligand hyaluronic acid which causes inflammation in the heart valves. A total of 107 valves were studied. Of the 61 mitral valves studied 38 (62.2%) showed CD44 positivity as brownish granules within the cytoplasm. Of the 46 aortic valves studied 19 (41.3%) showed CD44 positivity as brownish granules within the cytoplasm. The valves showed evidence of past inflammation showing thick and thin walled blood vessels and lymphocytes. CD44 protein increased in 62.2% of mitral valves, of which 60.5% were from patients presenting when they were less than 40 years old. CD44 protein increased in 41.3% of aortic valves, of which 63.15% were from patients presenting when they were less than 40 years old. CD44 positivity was seen in 57 valves as brownish granules within the cytoplasm of the cell. CD44 protein increased in 53.27% of mitral and aortic valves, of which 63.15% were from the males patients. CD44 protein increased in 53.27% of mitral and aortic valves, of which 36.84% were from the females patients. Conclusion/Recommendations: The results showed CD44 is over expressed in the heart valves removed surgically for stenosis or regurgitation where the hyaluronic acid content is high. © 2010 Science Publications.


Srinivasa Nageswara Rao G.,Tagore Medical College and Hospital | Gurumurthy P.,International Center for Cardio Thoracic and Vascular Diseases | Sruti E.,Tagore Medical College and Hospital | Cherian K.M.,International Center for Cardio Thoracic and Vascular Diseases
Journal of Clinical and Diagnostic Research | Year: 2013

Results: The serum neopterin levels Introduction: An adverse pattern of blood lipids and cardiovascular abnormalities starts in obese children during childhood and neopterin serves as a marker for cardiovascular disease. Unfortunately, the data for children and adolescents, particularly, in the Indian population, are scarce. The present study aimed at evaluating the levels of serum neopterin in obese and overweight children and adolescents of the Indian population. Methods: The study groups included 296 school going children and adolescents. (96 obese and 97 overweight subjects were compared with 103 normal controls who were aged between 10- 17 years). The anthropometric variables, the lipid profile, the fasting serum glucose which was analyzed by using an autoanalyzer and the serum neopterin levels were assayed by HPLC (Shimazdu) by using the method of Palfrey et al., 1993. The serum insulin levels were measured by using ELISA kits. significantly in the obese (7.4±1.4) and overweight (6.4±0.8) (p<0.001) children and adolescents than in the controls (4.9±0.9). The serum neopterin levels showed a positive correlation with the BMI (r=0.79), WHR (r=0.5), systolic (r=0.44) and diastolic blood pressures (r= 0.25), insulin (r=0.57), HOMAIR (r=0.55), total cholesterol (r=0.35), triglycerides (r=0.20) and LDL-C (r=0.27) and they showed a negative correlation with HDL-C (r=-0.15) and fasting glucose (r= -0.3). Conclusion: This study revealed a good relationship between serum neopterin and the anthropometric and biochemical parameters. We, therefore, aim to conduct regular camps at schools to counsel and advise the identified overweight and obese children to go for physical exercise and a balanced diet. The implementation of preventive measures from early childhood will have far reaching benefits, as even the prevalence of other obesity related disorders could decline.


Philip S.,St Gregorios Cardio Vascular Center | Varghese M.,St Gregorios Cardio Vascular Center | Manohar K.,St Gregorios Cardio Vascular Center | Manohar K.,International Center for Cardio Thoracic and Vascular Diseases | And 2 more authors.
European Journal of Echocardiography | Year: 2011

Absent pulmonary valve syndrome (APVS) is a rare conotruncal anomaly consisting of a severely hypoplastic pulmonary valve with annular stenosis, aneurysmal dilatation of main pulmonary artery with dilatation of one or both pulmonary artery branches, and a ventricular septal defect. Here, we report a prenatal echo diagnosis of APVS in a 27-year-old primi gravida at 20 weeks of gestation confirmed on fetal autopsy. A 'bow tie'-like hypoechoic shadow in fetal cardiac ultrasound observed by us in a modified four-chamber view was suggestive of aneurysmal dilatation of branch pulmonary arteries. The consequences of continuation of pregnancy including immediate neonatal complications and possible medical and multistaged surgical interventions were well explained. Parents opted for medical termination of pregnancy. Autopsy findings of the fetus were consistent with the prenatal echo diagnosis of APVS. The presence of patent ductus arteriosus seen in the autopsy may be the cause of severe heart failure evidenced by the abnormally large congested liver, dilated right heart chambers, and tricuspid valve annulus. We infer that the prenatal diagnosis of APVS may be possible with a high degree of accuracy with characteristic fetal echocradiographic findings such as 'bow tie'-like or 'ballooning'-like shadows observed in this case. The presence of ductus confirms definite fetal loss and the parents can be counselled accordingly. However, when the ductus is absent, decision-making is difficult as the fetus is going to survive. © The Author 2011.


Ashokkumar M.,International Center for Cardio Thoracic and Vascular Diseases | Emmanuel C.,Global Hospitals and Health City | Dhandapany P.S.,Madurai Kamaraj University | Dhandapany P.S.,Mount Sinai School of Medicine | And 4 more authors.
DNA and Cell Biology | Year: 2011

The chromosomal region 9p21 has been reported to be associated with myocardial infarction, coronary artery disease (CAD), diabetes, and many other related multifactorial diseases in humans. Although the genome-wide association studies have identified a limited number of single-nucleotide polymorphisms (SNPs) at 9p21 for CAD risk, the role of flanking SNPs has not been studied so far. Therefore, in the present work, we studied the role of flanking SNPs with respect to that of the previously identified SNPs rs10757278 and rs2383207 at 9p21 among the Indian subjects found to have CAD (n=414) along with age- and sex-matched control subjects (n=408). Our study replicated the association of genome-wide association studies that had identified SNPs rs2383207 (p=4.7×10-5) and rs10757278 (p=5.5×10-5) among Indians with CAD. Further, we evaluated nine additional SNPs, of which two SNPs flanking rs2383207 (rs1537375 [p=2.4×10-5] and rs1537374 [p=5.6×10-5]) were also strongly associated with CAD. The haplotypes constructed using four risk SNPs revealed that the haplotypes with combinations of rs10757278 showed CAD risks, whereas the minor alleles of rs2383207, rs1537375, and rs1537374 in combinations reduce the CAD risks substantially. Our study demonstrates that the variation in the chromosomal region 9p21 is involved in modifying progression toward CAD among Indians and the risk may be variable, contributed by the SNPs that are flanking previously identified SNPs. © Copyright 2011, Mary Ann Liebert, Inc.

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