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Kawsar F.,Marquette University | Ahamed S.,Marquette University | Love R.,International Breast Cancer Research Foundation
Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) | Year: 2015

Automatic activity detection is important for remote monitoring of elderly people or patients, for context-aware applications, or simply to measure one’s activity level. Recent studies have started to use accelerometers of smart phones. Such systems require users to carry smart phones with them which limit the practical usability of these systems as people place their phones in various locations depending on situation, activity, location, culture and gender. We developed a prototype for shoe based activity detection system that uses pressure data of shoe and showed how this can be used for remote monitoring. We also developed a multimodal system where we used pressure sensor data from shoes along with accelerometers and gyroscope data from smart phones to make a robust system. We present the details of our novel activity detection system, its architecture, algorithm and evaluation. © Springer International Publishing Switzerland 2015.

Adibuzzaman M.,Marquette University | Ahamed S.I.,Marquette University | Love R.,International Breast Cancer Research Foundation
Proceedings of the ACM Symposium on Applied Computing | Year: 2014

Smart phones with optical sensors have created new opportunities for low cost and remote monitoring of vital signs. In this paper, we present a novel approach to find heart rate, perfusion index and oxygen saturation using the video images captured by the camera of the smart phones with mathematical models. We use a technique called principal component analysis (PCA) to find the band that contain most plethysmographic information. Also, we showed a personalized regression model works best for accurately detecting perfusion index and oxygen saturation. Our model has high accuracy of the physiological parameters compared to the traditional pulse oxymeter. Also, an important relationship between frame rate for image capture, minimum peak to peak distance in the pulse wave form and accuracy has been established. We showed that there is an optimal value for minimum peak to peak distance for detecting heart rate accurately. Moreover, we present the evaluation of our personalized models. Copyright 2014 ACM.

Love R.R.,International Breast Cancer Research Foundation | Young G.S.,Ohio State University | Laudico A.V.,Philippine General Hospital | Van Dinh N.,Hospital K | And 11 more authors.
Cancer | Year: 2013

BACKGROUND In premenopausal women treated for breast cancer, loss of bone mineral density (BMD) follows from menopause induced by chemotherapy or loss of ovarian function biochemically or by surgical oophorectomy. The impact on BMD of surgical oophorectomy plus tamoxifen therapy has not been described. METHODS In 270 Filipino and Vietnamese premenopausal patients participating in a clinical trial assessing the impact of the timing in the menstrual cycle of adjuvant surgical oophorectomy on breast cancer outcomes, BMD was measured at the lumbar spine and femoral neck before this treatment, and at 6, 12, and 24 months after surgical and tamoxifen therapies. RESULTS In women with a pretreatment BMD assessment and at least 1 other subsequent BMD assessment, no significant change in femoral neck BMD was observed over the 2-year period (-0.006 g/cm 2, -0.8%, P =.19), whereas in the lumbar spine, BMD fell by 0.045 g/cm2 (4.7%) in the first 12 months (P <.0001) and then began to stabilize. CONCLUSIONS Surgically induced menopause with tamoxifen treatment is associated with loss of BMD at a rate that lessens over 2 years in the lumbar spine and no significant change of BMD in the femoral neck. Cancer 2013;119:3746-3752. © 2013 American Cancer Society.

Ginsburg O.M.,University of Toronto | Ginsburg O.M.,Womens College Research Institute | Love R.R.,Ohio State University | Love R.R.,International Breast Cancer Research Foundation
Breast Journal | Year: 2011

Recent progress with declines in mortality in some high-income countries has obscured the fact that for the majority of women worldwide who are newly diagnosed, breast cancer is a neglected disease in the context of other numerically more frequent health problems. For this growing majority, it is also an orphan disease, in that detailed knowledge about tumor characteristics and relevant host biology necessary to provide even basic care is absent. With the possible exception of nutritional recommendations, current international cancer policy and planning initiatives are irrelevant to breast cancer. The progress that has occurred in high-income countries has come at extraordinary fiscal expense and patient toxicity, which of themselves suggest nonrelevance to women and healthcare practitioners in middle- and low-income countries. The implications of these circumstances appear clear: if the promise of the now 60-year-old Declaration of Human Rights that the fruits of medical science accrue to all mankind is to be realized with respect to breast cancer, a basic and translational global research initiative should be launched. © 2011 Wiley Periodicals, Inc.

Love R.R.,Ohio State University | Love R.R.,International Breast Cancer Research Foundation
ONCOLOGY | Year: 2010

Reviews of issues around adjuvant hormonal therapies for breast cancer in premenopausal women often focus on recent and current large clinical trials, and fail to address other subjects that are very germane to evidence-based and investigatory clinical practice. These topics include: (1) the descriptive epidemiology of breast cancer globally, (2) critical issues in tumor hormone receptor testing, (3) compelling data demonstrating that hormone receptorpositive breast cancer is a chronic disease, (4) data supportive of combined hormonal therapy with tamoxifen as the standard of care, and the limited justifications for awaiting the SOFT and TEXT trial results, (5) pharmacogenetic hypotheses with tamoxifen, (6) ethical issues in ovarian suppression vs ablative treatment, and (7) emerging data about the importance of primary tumor removal surgery itself and surgical stress in solid tumor management.

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