International Agency for Research on Cancer WHO IARC Lyon France

France

International Agency for Research on Cancer WHO IARC Lyon France

France
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Chanudet E.,International Agency for Research on Cancer WHO IARC Lyon France | Wozniak M.B.,International Agency for Research on Cancer WHO IARC Lyon France | Bouaoun L.,International Agency for Research on Cancer WHO IARC Lyon France | Byrnes G.,International Agency for Research on Cancer WHO IARC Lyon France | And 5 more authors.
International Journal of Cancer | Year: 2017

Circulating miRNAs have shown great promises as noninvasive diagnostic and predictive biomarkers in several solid tumors. While the miRNA profiles of renal tumors have been extensively explored, knowledge of their circulating counterparts is limited. Our study aimed to provide a large-scale genome-wide profiling of plasma circulating miRNA in clear-cell renal cell carcinoma (ccRCC). Plasma samples from 94 ccRCC cases and 100 controls were screened for 754 circulating micro-RNAs (miRNA) by TaqMan arrays. Analyses including known risk factors for renal cancer-namely, age, sex, hypertension, obesity, diabetes, tobacco smoking and alcohol consumption-highlighted that circulating miRNA profiles were tightly correlated with the stage of the disease. Advanced tumors, characterized as stage III and IV, were associated with specific miRNA signatures that significantly differ from both controls and earlier stage ccRCC cases. Molecular pathway enrichment analyses of their gene targets showed high similarities with alterations observed in renal tumors. Plasma circulating levels of miR-150 were significantly associated with RCC-specific survival and could marginally improve the predictive accuracy of clinical parameters in our series, including age at diagnosis, sex and conventional staging. In summary, our results suggest that circulating miRNAs may provide insights into renal cell carcinoma progression. © 2017 UICC.

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