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Damgaard-Olesen A.,Copenhagen University | Damgaard-Olesen A.,Internat Center For Res And Res Training In Endocrine Disruption Of Male Reprod And Child Hea | Johannsen T.H.,Copenhagen University | Johannsen T.H.,Internat Center For Res And Res Training In Endocrine Disruption Of Male Reprod And Child Hea | And 13 more authors.
Clinica Chimica Acta | Year: 2016

We report reference ranges based on LC-MS/MS for testosterone (T), free testosterone (FT) and its precursors, i.e. 17-hydroxyprogesterone (17-OHP), dehydroepiandrosterone (DHEA), DHEA-sulfate (DHEAS) and androstenedione (Adione), in relation to different health markers and lifestyle factors.The study was based on 304 healthy men aged 30-61 years participating in a population-based cross-sectional study (Health2008). Examination program consisted of a clinical examination, completion of a self-administered questionnaire and blood sampling. Steroid metabolites were measured by a validated and sensitive LC-MS/MS method.Older age-groups were significantly associated with decreased concentrations of DHEA, DHEAS, Adione, and FT, while no significant associations with age were shown for 17-OHP or T. Participants with BMI≥30 kg/m2 had lower age-related steroid metabolite z-scores compared to participants with BMI<30 kg/m2, i.e. 17-OHP: -0.51 vs. 0.08 (p<0.001); DHEA: -0.27 vs. 0.09 (p=0.014); Adione: -0.29 vs. 0.09 (p=0.012); T: -0.99 vs. 0.14 (p<0.001); and FT -0.55 vs. 0.05 (p<0.001), respectively. In conclusion, this large study on serum steroid metabolites and concomitant assessment of health markers in healthy men provides age-related reference ranges, and furthermore evaluates the impact of lifestyle factors and metabolic syndrome on androgen metabolite levels. © 2015 Elsevier B.V. Source

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