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Grand Island, NE, United States

Chakraborty S.,University of Nebraska Medical Center | Donner M.,Internal Medical Associates of Grand Island | Colan D.,Internal Medical Associates of Grand Island
Anticancer Research | Year: 2013

Herpes simplex virus 1 (HSV-1) is the principal cause of viral necrotizing encephalitis in developed countries. Small cell carcinoma of the lung accounts for about 15% of all lung cancer. HSV induced encephalitis (HSE) following prophylactic cranial irradiation (PCI) in SCLC is rare. Here, we describe the case of a 58-year-old woman with limited stage SCLC, multiple sclerosis (MS) and cutaneous lupus who developed fatal HSE following PCI. We review the literature to investigate the inter-relationships between these diseases and management of HSE. Source


Chakraborty S.,University of Nebraska Medical Center | Keenportz B.,Saint Francis Medical Center College of Nursing | Woodward S.,Saint Francis Medical Center College of Nursing | Anderson J.,Internal Medical Associates of Grand Island | Colan D.,Internal Medical Associates of Grand Island
American Journal of Clinical Oncology: Cancer Clinical Trials | Year: 2015

Leukemoid reaction is defined as leucocytosis >50,000/μL. When it occurs in association with a malignancy, and infection or leukemia has been ruled out, it is termed as paraneoplastic leukemoid reaction. A patient presented with fatigue, generalized weakness, and abdominal distension and was incidentally noted to have a white blood cell count of 139,000/μL. Leukemia was ruled out by peripheral smear and flow cytometry. Computed tomography-guided biopsy of thickened omentum revealed poorly differentiated metastatic carcinoma. He died 3 days after admission with a peak white blood cell count of 180,000/μL. Previous reports and pathophysiology of paraneoplastic leukemoid reaction are reviewed. © 2013 Wolters Kluwer Health, Inc. All rights reserved. Source

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