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New Haven, CT, United States

Gommans W.M.,InteRNA Technologies
Seminars in Cell and Developmental Biology | Year: 2012

An important epigenetic mechanism in mammals is adenosine deamination, which generates transcriptome variety through the conversion of single adenosines into inosines in RNA molecules. Inosine is interpreted as guanosine by the translational machinery, and when A-to-I RNA editing occurs in the coding region of pre-mRNA molecules this substitution can result in non-synonymous codon changes and subsequent altered protein function. Furthermore, editing can also take place in non-coding RNA molecules, including pri-miRNAs. In this review I intend to give an overview on the interplay between miRNA-mediated control of gene expression and RNA editing, and how editing could impact cellular behavior by influencing mature miRNA expression levels. © 2011 Elsevier Ltd. Source


The invention relates to the diagnostic and therapeutic uses of a miRNA molecule, an equivalent or a source thereof in a disease and condition associated with neo-angiogenesis.


The invention relates to the diagnostic and therapeutic uses of a miRNA molecule, an equivalent or a source thereof in a disease and condition associated with melanoma or a disease or a condition associated with activated BRAF pathway.


The invention relates to the diagnostic and therapeutic uses of a miRNA molecule or an equivalent thereof wherein a source of said miRNA molecule or equivalent thereof comprises at least 80 nucleotides and comprises a motif having at least 98% identity with the motif represented by SEQ ID NO:1 or a source thereof in a disease and condition associated with EMT (Epithelial to Mesenchymal Transition).


Patent
InteRNA Technologies | Date: 2012-12-20

The invention relates to the diagnostic and therapeutic uses of a miRNA-323, miRNA-342, miRNA-326, miRNA-371, miRNA-3157 and/or miRNA-345 molecule, an equivalent or a source thereof in a disease and condition associated with a squamous cell carcinoma such as head and neck cancer or a preneoplastic mucosal change.

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