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Gustafson D.R.,Gothenburg University | Gustafson D.R.,SUNY Downstate Medical Center | Mazzuco S.,University of Padua | Ongaro F.,University of Padua | And 11 more authors.
American Journal of Geriatric Psychiatry | Year: 2012

Objectives: The concurrent contributions of dynamic, interrelated late-life parameters, such as body mass index (BMI), cognition, and physical functioning on mortality in the elderly are unclear, as is the influence of APOE genotype. We explored these measures in relation to 7-year mortality in long-lived Italian elderly. Design: A representative, age-stratified, population sample. Setting: The Treviso Longeva (TRELONG) Study, in Treviso, Italy. Participants: Three hundred eleven men and 357 women, aged 70 years and older (mean age 84 ± 8 years). Measurements: Seven-year mortality, BMI, Mini-Mental State Examination (MMSE) score, Activities of Daily Living (ADL), APOE genotype, and a variety of clinical and survey data. Results: In separate age-and sex-adjusted analyses, BMI <18.5 kg/m, MMSE ≤24, and ADL <6, were associated with greater 7-year mortality among adults aged 70 years and older. In a multivariate model including all factors, MMSE ≤24, and ADL <6 were associated with greater mortality; BMI ≥30 kg/m was protective. There were no interactions between BMI, MMSE, or ADL. When excluding those dying within 3 years of baseline, only an MMSE ≤24 was related to mortality. APOEε4 was not related to mortality. CONCLUSION:: Higher MMSE score, higher ADL score, and higher BMI, independent of age, sex, and other factors, are markers for longer life among northern Italian adults aged 70 years or older. Global cognition, BMI, and physical functioning, assessed by short, simple tests are profound indicators of death within less than a decade. © 2012 American Association for Geriatric Psychiatry.


Gallucci M.,General Hospital of Treviso | Gallucci M.,Interdisciplinary Geriatric Research Foundation | Flores-Obando R.,SUNY Downstate Medical Center | Mazzuco S.,University of Padua | And 12 more authors.
International Journal of Biological Markers | Year: 2014

Introduction: It has been reported that elderly subjects have a compromised ability to produce melatonin nightly, and thatreduced melatonin levels may be a risk factor for cancer. The purpose of this study was to evaluate the relationship betweenmelatonin levels and chronic diseases in a cohort of elderly subjects using the Charlson comorbidity index (CCI).Design: We performed a secondary data analysis of a longitudinal study of a representative, age-stratified, samplepopulation.Setting: The Treviso Longeva (Trelong) study, in Treviso, Italy.Participants: A total of 114 men and 146 women, aged 77 years and older, still alive after 7 years of follow-up.Measurements: As an estimation of serum melatonin secretion levels, urinary 6-sulfatoxymelatonin (aMT6s) was assayedin the urine of 260 elderly subjects using an enzyme-linked immunosorbent assay (ELISA) kit (product 01-EK-M6S, ALPCOImmunoassays, Windham, NH). All aMT6s levels were creatinine standardized ([aMT6s]/[creatinine]), and the CCI was calculated.Results: The melatonin levels decreased with aging despite not reaching statistical significance, and the decrease was more evident in males than in females (40.5 ng vs 47.0 ng aMT6s/mg creatinine, ns). Melatonin levels were significantly lower in patients reporting insomnia (p=0.05). The CCI score was inversely correlated with the levels of melatonin (p=0.03). Melatoninlevels of subjects affected by CCI pathologies were significantly lower than those of healthy subjects (p=0.03) and ofsubjects suffering from diseases not included in the CCI and, therefore, less severe (p=0.03).Conclusion: Melatonin appears to be a marker of disease state and severity, as well as of sleep disorders, in the elderly. These early findings would confirm the protective role of melatonin against several chronic diseases. The benefits of this agent as apossible medication should be more thoroughly clinically tested. © 2014 Wichtig Publishing.


Albani D.,Irccs Instituto Of Ricerche Farmacologiche Mario Negri | Ateri E.,Irccs Instituto Of Ricerche Farmacologiche Mario Negri | Mazzuco S.,University of Padua | Ghilardi A.,Irccs Instituto Of Ricerche Farmacologiche Mario Negri | And 15 more authors.
Age | Year: 2014

Human sirtuins are seven proteins with deacetylase activity that are emerging as key modulators of basic physiological functions. Some evidence links SIRT3 to longevity in mammals. This study aimed to investigate whether variants within SIRT3 gene were associated to human longevity. We analyzed 549 genomic DNA collected during the prospective study "Treviso Longeva," including elderly over 70 years of age from the municipality of Treviso, a small city in the northeast of Italy. We genotyped SIRT3 rs3825075, rs4980329, and rs11555236 single nucleotide polymorphisms (SNPs) by real-time polymerase chain reaction allelic discrimination assay. A cross-sectional analysis performed by comparing people over and under 85 years of age did not evidence association among the SIRT3 SNPs and longevity. However, when we performed a longitudinal analysis considering mortality as a dependent variable, we observed an association of SIRT3 rs11555236 and rs4980329 with longevity in the whole population (p values corrected for potential confounders=0.04 and 0.03, respectively). After stratification according to gender, the same SNPs were associated to female longevity only (p values corrected for potential confounders=0.03 and 0.02, respectively). Finally, as rs11555236 was reported to be in linkage disequilibrium with a putative functional enhancer within the SIRT3 gene, we assessed whether rs11555236 genotypes correlated with a different level of SIRT3 protein in peripheral blood mononuclear cells.We found an increased level of SIRT3 in subjects homozygous for the (T) allele. We suggest that SIRT3 genetic variability might be relevant for the modulation of human longevity in the Italian population. © American Aging Association 2013.


Gallucci M.,General Hospital of Treviso | Gallucci M.,Interdisciplinary Geriatric Research Foundation | Ongaro F.,University of Padua | Meggiolaro S.,University of Padua | And 13 more authors.
Archives of Gerontology and Geriatrics | Year: 2011

Prolongation of life is an important public health goal as long as there is an emphasis on the quality of life (QoL) and independent living. Diminishing abilities to ambulate and participate in activities of daily living point to a serious decline in functional health, increasing the risk of institutionalization and death. In our work we found a pattern of factors associated with disability, especially cognitive impairment, as well as stroke, physical activity and performance, reading, and the nutritional biomarkers, blood albumin and high-density lipoprotein cholesterol (HDL-C). The attention to this cluster of markers, suggesting multidimensional prevention, may have unexpected good effects against disability. © 2010 Elsevier Ireland Ltd.


Albani D.,Irccs Instituto Of Ricerche Farmacologiche Mario Negri | Mazzuco S.,University of Padua | Chierchia A.,Irccs Instituto Of Ricerche Farmacologiche Mario Negri | Fusco F.,Irccs Instituto Of Ricerche Farmacologiche Mario Negri | And 13 more authors.
International Journal of Molecular Epidemiology and Genetics | Year: 2015

Studies on sirtuins (SIRT), a family of proteins with deacetylase activity, have provided convergent evidence of the key role of these enzymes in aging-linked physiological functions. The link between SIRT1 and longevity has emerged in model organism but few data are available in humans, in particular relying on longitudinal studies. Here, we assessed whether a genetic variant within SIRT1 gene promoter (rs12778366) was associated to human longevity. We analyzed 586 genomic DNA (gDNA) collected in the study “Treviso Longeva” (TRELONG), including elderly over 70 years of age from the municipality of Treviso, a town in the Northeast of Italy, with a 11-year follow-up. We genotyped SIRT1 rs12778366 by real-time polymerase chain reaction (RT-PCR) allelic discrimination assay. A cross-sectional analysis performed by comparing people over and under 85 years of age did not evidence association between rs12778366 and longevity. When we performed a longitudinal analysis considering mortality as dependent variable, we did not observe an association of rs12778366 with longevity in the whole population (corrected P-value = 0.33). However, when we stratified the TRELONG subjects according to circulating level of interleukin- 6 (IL-6), a predictor of disability and mortality, we found that rs12778366 (TC+CC) carriers were at increased risk of mortality in comparison to the TT reference group (corrected P-value = 0.03, HR 1.47). Our data do not support a major role of rs12778366 in human longevity, but the stratified analysis on IL-6 suggests that this variant may be involved in the detrimental effect of high circulating IL-6 in the elderly. © 2015, E-Century Publishing Corporation. All rights reserved.


Fougere B.,Toulouse 1 University Capitole | Fougere B.,French Institute of Health and Medical Research | Mazzuco S.,University of Padua | Spagnolo P.,General Hospital of Treviso | And 7 more authors.
Journal of Nutrition, Health and Aging | Year: 2016

Objectives: To determine the association between Mediterranean-Style Dietary Pattern Score and physical performance. Design: Data analysis of a longitudinal study of a representative, age stratified, population sample. Setting: The TREVISO LONGEVA (TRELONG) Study, in Treviso, Italy. Participants: In 2010, 123 men and 181 women, age 77 years and over (mean age 86.3 ± 6.8 years). Measurements: Performing a logistic regression in a multivariate analysis, hand grip strength and Short Physical Performance Battery (SPPB) were tested in relation to Mediterranean-Style Dietary Pattern Score (MSDPS). Results: The hand grip mean value was 10.9 kg (± 9.5) and the SPPB score was 6.3 (± 3.8). The MSDPS mean value in this study sample was 38.1/100 (± 8.1). A significant association (p=0.036) between a high adherence to the Mediterranean diet (fourth quartile) and higher performance lower limbs (SPPB>7) was found. No correlation was reported for the hand grip strength. Conclusion: We found an association statistically significant between a high adherence to the Mediterranean diet and higher physical performance. © 2016, Serdi and Springer-Verlag France.


Gallucci M.,General Hospital of Treviso | Gallucci M.,Interdisciplinary Geriatric Research Foundation | Mazzuco S.,University of Padua | Ongaro F.,University of Padua | And 12 more authors.
Journal of Nutrition, Health and Aging | Year: 2013

Objectives: The relative contributions of risk factors, as body mass index (BMI), depression, chronic diseases, smoking, and lifestyles (as physical and performance activity, social contacts and reading habit) to cognitive decline in the elderly are unclear. We explored these variables in relation to 7-year cognitive decline in long-lived Italian elderly. Design: Secondary data analysis of a longitudinal study of a representative, age-stratified, population sample. Setting: The TREVISO LONGEVA (TRELONG) Study, in Treviso, Italy. Participants: 120 men and 189 women, age 77 years and older (mean age 80.2 ± 6.9 years) survivors after seven years of follow up. Measurements: Cognitive decline measured as difference between Mini-Mental State Examination (MMSE) score in 2003 and in 2010; Body mass index (BMI), handgrip, Short Physical Performance Battery (SPPB) score, social contacts, reading habit, sight, hearing, schooling, mediterranean diet and multiple clinical and survey data recorded at baseline in 2003. Results: In separate univariate analyses, age, SPPB score < 5, depressive symptoms (GDS) and more comorbidities (CCI) were associated with greater cognitive decline. Otherwise higher BMI, higher handgrip, reading habit, non-deteriorated sight and hearing, and schooling were protective. In a final multivariate model, age and higher BMI were associated with greater cognitive decline while reading habits was protective. SPPB score < 5 tends, though weakly, to be associated with greater cognitive decline. These associations remained with multivariate adjustment for gender, schooling, Charlson co-morbidity index (CCI) and baseline MMSE. Conclusion: Age and higher baseline BMI, independent of gender, and other confounding factors, are risk factors for cognitive decline. Reading habit plays a protective role seven years later among northern Italian adults aged 70 years or older. Low physical performance tends, though weakly, to be associated with greater cognitive decline. © 2013 Serdi and Springer-Verlag France.


Fougere B.,Toulouse 1 University Capitole | Fougere B.,French Institute of Health and Medical Research | Vellas B.,Toulouse 1 University Capitole | Vellas B.,French Institute of Health and Medical Research | And 6 more authors.
Ageing Research Reviews | Year: 2015

The rapid growth in the number of older adults has many implications for public health, including the need to better understand the risks posed by environmental exposures. Aging leads to a decline and deterioration of functional properties at the cellular, tissue and organ level. This loss of functional properties yields to a loss of homeostasis and decreased adaptability to internal and external stress. Frailty is a geriatric syndrome characterized by weakness, weight loss, and low activity that is associated with adverse health outcomes. Frailty manifests as an age-related, biological vulnerability to stressors and decreased physiological reserves. Ambient air pollution exposure affects human health, and elderly people appear to be particularly susceptible to its adverse effects.The aim of this paper is to discuss the role of air pollution in the modulation of several biological mechanisms involved in aging. Evidence is presented on how air pollution can modify the bidirectional association between successful and pathological aging throughout the frailty conditions. © 2015 Elsevier B.V.

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