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Bhalerao S.,Interactive Research School for Health Affairs | Hegde M.,Bharati Vidyapeeth Deemed University | Katyare S.,Bharati Vidyapeeth Deemed University | Kadam S.,Interactive Research School for Health Affairs
World's Poultry Science Journal | Year: 2014

Similar to omega-3 eggs, chicken meat has great potential to become a functional food for humans. In India, chicken meat is preferred due to its perceived health benefits and affordability. The balance between omega 3 and 6 fatty acids is crucial for its usefulness in animals. At present commercial chicken meat has low omega-3 fatty acid content and higher omega-6 fatty acid content. Published research shows that it is possible to modify the lipid profile of commercial chickens by manipulating the broiler diet. The modern human diet is deficient in n-3 FAs, which has been linked to the increase in several degenerative diseases such as cardiovascular disease, diabetes, arthritis, cancer and mental illness. Therefore omega-3 chicken meat may be an effective means of increasing n-3 FA in the human diet. There are several problems associated with the commercial production of omega-3 chicken meat related to the choice of source of fatty acids in the feed, cost of production, consumer acceptability and stability of the chicken meat that need to be tackled. The present article briefly reviews the studies carried out in this respect, the possible impact of omega-3 chicken meat production on the poultry industry, and on human health. © 2014 World's Poultry Science Association.

Malonia S.K.,National Center for Cell Science | Sinha S.,National Center for Cell Science | Lakshminarasimhan P.,Gothenburg University | Singh K.,Cleveland Clinic Lerner Research Institute | And 4 more authors.
Biochimica et Biophysica Acta - Reviews on Cancer | Year: 2011

Changes in the composition of nuclear matrix associated proteins contribute to alterations in nuclear structure, one of the major phenotypes of malignant cancer cells. The malignancy-induced changes in this structure lead to alterations in chromatin folding, the fidelity of genome replication and gene expression programs. The nuclear matrix forms a scaffold upon which the chromatin is organized into periodic loop domains called matrix attachment regions (MAR) by binding to various MAR binding proteins (MARBPs). Aberrant expression of MARBPs modulates the chromatin organization and disrupt transcriptional network that leads to oncogenesis. Dysregulation of nuclear matrix associated MARBPs has been reported in different types of cancers. Some of these proteins have tumor specific expression and are therefore considered as promising diagnostic or prognostic markers in few cancers. SMAR1 (scaffold/matrix attachment region binding protein 1), is one such nuclear matrix associated protein whose expression is drastically reduced in higher grades of breast cancer. SMAR1 gene is located on human chromosome 16q24.3 locus, the loss of heterozygosity (LOH) of which has been reported in several types of cancers. This review elaborates on the multiple roles of nuclear matrix associated protein SMAR1 in regulating various cellular target genes involved in cell growth, apoptosis and tumorigenesis. © 2010 Elsevier B.V.

Pillai A.,Georgia Regents University | Pillai A.,Charlie Norwood Medical Center | Kale A.,Interactive Research School for Health Affairs | Joshi S.,Interactive Research School for Health Affairs | And 5 more authors.
International Journal of Neuropsychopharmacology | Year: 2010

Brain-derived neurotrophic factor (BDNF), which plays an important role in neurodevelopmental plasticity and cognitive performance, has been implicated in neuropsychopathology of schizophrenia. We examined the levels of both cerebrospinal fluid (CSF) and plasma BDNF concomitantly in drug-naive first-episode psychotic (FEP) subjects with ELISA to determine if these levels were different from control values and if any correlation exists between CSF and plasma BDNF levels. A significant reduction in BDNF protein levels was observed in both plasma and CSF of FEP subjects compared to controls. BDNF levels showed significant negative correlation with the scores of baseline PANSS positive symptom subscales. In addition, there was a significant positive correlation between plasma and CSF BDNF levels in FEP subjects. The parallel changes in BDNF levels in plasma and CSF indicate that plasma BDNF levels reflect the brain changes in BDNF levels in schizophrenia. Copyright © CINP 2009.

Hussain A.J.,Directorate of Rice Research | Hussain A.J.,Seed Works India Pvt Ltd | Ali J.,International Rice Research Institute | Siddiq E.A.,Directorate of Rice Research | And 6 more authors.
Plant Breeding | Year: 2012

Genetic analysis of F 2 and backcross populations of an induced temperature-sensitive genic male sterility (TGMS) mutant source F 61 with normal pollen parents revealed that TGMS trait was controlled by a single recessive gene. Molecular tagging of TGMS trait was attempted using polymorphic randomly amplified polymorphic DNA (RAPD) and simple sequence repeats (SSR) markers through bulked segregant analysis. The RAPD primers UBC 345 830, UBC 313 927, microsatellites RM224 and RM21 produced putative markers, which differentiate parents and bulks from sterile parent and sterile bulks. The RAPD analysis of individual F 2 plants with the primer UBC345 830 showed perfect marker-phenotype cosegregation. The 830-bp RAPD fragment, which segregated with TGMS locus at a distance of 1.33cM, was eluted and cloned, and sequence information was used for designing sequence-characterized amplified region (SCAR) primer, which cosegregated with TGMS locus at a distance of 0.8cM. TGMS locus was mapped onto chromosome 11 using RM21 and RM224, flanking it at a distance of 4.3 and 3.0cM, respectively. The DNA markers tightly linked to TGMS gene (tms8) in F 61 can be cost effectively used for marker-assisted selection of TGMS trait. © 2011 Blackwell Verlag GmbH.

Wani K.D.,Interactive Research School for Health Affairs | Kitture R.,Fergusson College | Ahmed A.,Interactive Research School for Health Affairs | Choudhari A.S.,Interactive Research School for Health Affairs | And 4 more authors.
Journal of Bionanoscience | Year: 2011

Curcumin, a naturally occurring polyphenol extracted from turmeric (Curcuma longa), an indispensable culinary spice in Indian diet, has been known to function as a potent anticancer agent. However, its limited solubility and absorption into body tissues limits its bioavailability. Magnetic nanoparticles, typically Fe 3O 4, have been shown to possess various biomedical applications including hyperthermia, MRI, magnetic separation and targeted drug delivery. In the present paper, we report the synthesis of a highly aqueous stable suspension of citric acid (CA) capped iron oxide (Fe 3O 4) nanoparticles conjugated to curcumin (CU). The significance of this report lies in the use of citric acid as a capping agent for magnetic nanoparticles in combination with curcumin. Citric acid has been mainly used to overcome the problem of limited bioavailability of curcumin as well as to impart ferrofluid property to the nanoparticles. The Curcumin-Citric acid-Fe 3O 4 nanoparticles (CCF) were duly characterized by X-ray diffraction (XRD) and conjugated nanoparticles were confirmed by Fourier transform infrared spectroscopy (FTIR). The percent drug loading was evaluated by thermo gravimetric analysis (TGA). CCF nanoparticles were studied in vitro to determine whether the curcumin retained its anticancer activity after conjugation with citric acid capped nanoparticles. In vitro uptake of CCF nanoparticles into breast cancer cell line, MCF7, was confirmed by Prussian blue staining. MTT assay was performed to determine cytotoxicity of the nanoparticles towards MCF7. Growth assays proved that the anticancer activity of curcumin was retained even after conjugation with CA. © 2011 American Scientific Publishers All rights reserved.

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