Amsterdam, Netherlands
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Cheng C.-W.,Hong Kong Baptist University | Kwok A.O.L.,Medical Center | Bian Z.-X.,Hong Kong Baptist University | Tse D.M.W.,Intensive Care Unit ICU
Evidence-based Complementary and Alternative Medicine | Year: 2012

Constipation is a common problem in advanced cancer patients; however, specific clinical guidelines on traditional Chinese medicine (TCM) syndrome (Zhang) are not yet available. In this cross-sectional study, the TCM syndromes distribution and their common symptoms and signs among 225 constipated advanced cancer patients were determined. Results showed that 127 patients (56.4%) and 7 patients (3.1%) were in deficient and excessive patterns, respectively, while 91 patients (40.4%) were in deficiency-excess complex. The distributions of the five syndromes were: Qi deficiency (93.3%), Qi stagnation (40.0%), blood (Yin) deficiency (28.9%), Yang deficiency (22.2%), and excess heat (5.8%). Furthermore, age, functional status, and level of blood haemoglobin were factors related to the type of TCM syndrome. A TCM prescription with the functions on replenishing the Deficiency, redirecting the flow of Qi stagnation and moistening the dryness caused by the blood (Yin) deficiency can be made for the treatment of advance cancer patients with constipation. Robust trials are urgently needed for further justifying its efficacy and safety in evidence-based approaches. © 2012 Chung-Wah Cheng et al.


Janssen G.H.W.,Intensive Care Unit ICU | Rijkenberg S.,Intensive Care Unit ICU | Van Der Voort P.H.J.,Intensive Care Unit ICU | Van Der Voort P.H.J.,TIAS School for Business and Society
Journal of Electrocardiology | Year: 2016

Introduction Prolongation of the corrected QT interval (QTc) can lead to torsades de pointes. This study is designed to determine the validity of the continuous QTc (cQTc) measurement in critically ill patients. Methods In a retrospective cohort study, QTc analysis was performed with manual measurements on a single selected lead from a 12-lead ECG and cQTc measurement obtained at the same time. In addition, automated QTc measurement from the 12-lead ECG was also included in the study. Validation was performed by calculating intraclass correlation coefficient (ICC), Pearson's correlation and Bland-Altman plot. Results 119 patients with QRS < 120 ms were included with a mean cQTc of 468 ms (standard deviation (SD) 37) and mean manually measured QTc of 449 ms (SD 41) (p < 0.001). Pearson's correlation was 0.65 (p < 0.01), ICC was 0.65 (95% CI: 0.53-0.74). Bland-Altman plot shows a mean difference of 19.5 ms (limits of agreement (LOA) - 44.6 to 83.7). For cQTc compared to automated QTc from the 12-lead ECG the intraclass correlation coefficient was 0.77 (95% CI: 0.68-0.83, p < 0.001) and the Bland-Altman plot shows a mean difference of 7.8 ms (LOA - 40.2 to 55.8). Conclusion cQTc measurement in critically ill patients with a QRS duration shorter than 120 ms shows an acceptable accuracy to be used in routine care. © 2016 Elsevier Inc.

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