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Wang M.,Intelligent Polymer Research Institute | Wang J.,Institute for Superconducting and Electronic Materials | Hou Y.,Intelligent Polymer Research Institute | Shi D.,Institute for Superconducting and Electronic Materials | And 6 more authors.
ACS Applied Materials and Interfaces | Year: 2015

Nitrogen-doped crumpled graphene (NCG) is successfully synthesized via vapor phase deposition of polypyrrole onto graphene aerogel followed by thermal treatment. The NCG was explored as an electrocatalyst for the oxygen reduction reaction, showing comparable electrocatalytic performance with the commercial Pt/C in alkaline membrane exchange fuel cells because of the well-regulated nitrogen doping and the robust micro-3D crumpled porous nanostructure. © 2015 American Chemical Society.


Vine K.L.,Center for Medical Bioscience | Vine K.L.,Illawarra Health and Medical Research Institute | Chandran V.I.,Center for Medical Bioscience | Chandran V.I.,Illawarra Health and Medical Research Institute | And 8 more authors.
Current Cancer Drug Targets | Year: 2012

Tumor-specific delivery of ligand-directed prodrugs can increase the therapeutic window of chemotherapeutics by maintaining efficacy whilst decreasing toxic side effects. We have previously described a series of synthetic Nalkylated isatin cytotoxins that destabilize microtubules and induce apoptosis with 10-fold greater potency than conventional anti-mitotics in vitro. Here, we report the characterization, in vitro cytotoxicity and in vivo efficacy of a lead compound, 5,7-dibromo-N-(p-hydroxymethylbenzyl)isatin (N-AI) conjugated via an esterase-labile linker (N-AIE) to two proven targeting ligands, transferrin (Tf) and plasminogen activator inhibitor type 2 (PAI-2/serpinB2). N-AI was released from N-AIE and the targeting ligands Tf/PAI-2 in an esterase-dependent manner at 37 °C and both Tf- and PAI-2-N-AIE conjugates were stable at physiological pH. Human cancer cell lines which vary in their expression levels of Tf receptor (TfR/CD71) and PAI-2 target, receptor bound urokinase (uPA) selectively internalized the conjugates. Tf-N-AIE was up to 24 times more active than the free drug and showed clear selectivity patterns based on TfR levels. PAI-2-N-AIE showed equivalent activity compared to the parent drug and strong selectivity patterns for uPA levels. In preliminary in vivo experiments, the PAI-2- and Tf-N-AIE conjugates were efficacious at 1/20th and 1/10th of the dose of the free N-AI, respectively, in a metastatic, orthotopic human breast tumor xenograft mouse model. Thus, this strategy specifically delivers and concentrates a novel class of isatin-based, tubulin destabilizing agents to tumors in vivo and warrants further detailed preclinical investigation. © 2012 Bentham Science Publishers.


Wang M.,Huaihai Institute of Technology | Wang M.,University of Wollongong | Huang J.,Huaihai Institute of Technology | Tong Z.,Huaihai Institute of Technology | And 3 more authors.
Journal of Alloys and Compounds | Year: 2013

Cubic Cu2O nanoparticles have been successfully synthesized on n-propylamine (PA) intercalated graphene oxide (GO) with uniform distribution followed with a subsequent hydrazine hydrate reduction process to generate Cu2O/PA/rGO composite. For comparison, Cu2O conjugated reduced graphene oxide (Cu2O/rGO) composite was also synthesized using the same method. The as-prepared Cu2O/PA/rGO and Cu 2O/rGO nanocomposites are characterized by X-ray photoelectron spectroscopy (XPS), X-ray diffraction (XRD) spectroscopy, infrared spectroscopy (IR), scanning electron microscopy (SEM), transmission electron microscopy (TEM), Brunauer-Emmett-Teller (BET) surface area analysis, and Electrochemical impedance spectra (EIS) measurements. UV/vis diffuse reflectance spectroscopy was employed to estimate band gap energies of cuprous oxide composites. The results show that the intercalation of PA into the layered GO increases the surface area of the composites and provides an efficient strategy to load Cu2O due to the large and uniform distribution of active sites for anchoring copper ions. The surface area of the Cu2O/PA/rGO (123 m2/g) nanocomposite was found to be almost 2.5 times higher than that of Cu2O/rGO (55.7 m2/g). The as-prepared Cu 2O/PA/rGO show significant improvement on both adsorption capacity and photocatalytic activity towards organic pigment pollution compared with Cu2O/rGO under identical performance conditions. © 2013 Elsevier B.V. All rights reserved.


Moulton S.E.,Intelligent Polymer Research Institute | Wallace G.G.,University of Wollongong
Journal of Controlled Release | Year: 2014

Drug delivery from 3-dimensional (3D) structures is a rapidly growing area of research. It is essential to achieve structures wherein drug stability is ensured, the drug loading capacity is appropriate and the desired controlled release profile can be attained. Attention must also be paid to the development of appropriate fabrication machinery that allows 3D drug delivery systems (DDS) to be produced in a simple, reliable and reproducible manner. The range of fabrication methods currently being used to form 3D DDSs include electrospinning (solution and melt), wet-spinning and printing (3-dimensional). The use of these techniques enables production of DDSs from the macro-scale down to the nano-scale. This article reviews progress in these fabrication techniques to form DDSs that possess desirable drug delivery kinetics for a wide range of applications. © 2014 Elsevier B.V.


Zhang Y.,ICT Research Institute | Zhang Y.,Intelligent Polymer Research Institute | Ogunbona P.O.,ICT Research Institute | Li W.,ICT Research Institute | And 2 more authors.
ICASSP, IEEE International Conference on Acoustics, Speech and Signal Processing - Proceedings | Year: 2016

We consider the problem of learning a structured and discriminative dictionary based on sparse representation for classification task. The structure comprises class-shared and class-specific partitions which allows the separation of common and class-specific information in the data for classification. The resulting optimization problem was a max margin formulation that exploits the hinge loss function property. Comparative evaluation of the proposed classifier against four recent alternatives in a gender classification task indicates a 3-percenatge point improvement. © 2016 IEEE.


Zhao J.,Intelligent Polymer Research Institute | Zhang W.,Intelligent Polymer Research Institute | Zhang W.,University of Sydney | Sherrell P.,Intelligent Polymer Research Institute | And 4 more authors.
ACS Applied Materials and Interfaces | Year: 2012

A highly sensitive and selective dopamine sensor was fabricated with the unique 3D carbon nanotube nanoweb (CNT-N) electrode. The as-synthesised CNT-N was modified by oxygen plasma to graft functional groups in order to increase selective electroactive sites at the CNT sidewalls. This electrode was characterized physically and electrochemically using HRSEM, Raman, FT-IR, and cyclic voltammetry (CV). Our investigations indicated that the O 2-plasma treated CNT-N electrode could serve as a highly sensitive biosensor for the selective sensing of dopamine (DA, 1 μM to 20 μM) in the presence of ascorbic acid (AA, 1000 μM). © 2011 American Chemical Society.


Crook J.M.,Intelligent Polymer Research Institute | Crook J.M.,University of Melbourne | Crook J.M.,University of Wollongong | Wallace G.,Intelligent Polymer Research Institute | And 2 more authors.
Expert Review of Neurotherapeutics | Year: 2015

There is an urgent need for new and advanced approaches to modeling the pathological mechanisms of complex human neurological disorders. This is underscored by the decline in pharmaceutical research and development efficiency resulting in a relative decrease in new drug launches in the last several decades. Induced pluripotent stem cells represent a new tool to overcome many of the shortcomings of conventional methods, enabling live human neural cell modeling of complex conditions relating to aberrant neurodevelopment, such as schizophrenia, epilepsy and autism as well as age-associated neurodegeneration. This review considers the current status of induced pluripotent stem cell-based modeling of neurological disorders, canvassing proven and putative advantages, current constraints, and future prospects of next-generation culture systems for biomedical research and translation. © Informa UK, Ltd.


De Silva D.A.,University of Wollongong | Martens P.J.,University of New South Wales | Gilmore K.J.,Intelligent Polymer Research Institute | Panhuis M.I.H.,University of Wollongong | Panhuis M.I.H.,Intelligent Polymer Research Institute
Journal of Applied Polymer Science | Year: 2014

Ionic-covalent entanglement (ICE) hydrogels are a recently introduced new type of robust materials for potential future application in the fields of tissue engineering and soft robotics. Here the degradation behavior of gellan gum/polyacrylamide ICE hydrogels immersed in PBS or enzyme solutions is presented. It is demonstrated that ICE gels immersed in enzymes became stiffer, whereas under cyclic testing their mechanical responses stabilize after 10 loading/unloading cycles whether immersed in PBS or enzyme solutions. The leachates of the ICE hydrogels were found to be non-cytotoxic for the growth of L929 and PC12 cells. These findings will be of benefit to the future development of tissue engineering applications based on these gel materials. © 2014 Wiley Periodicals, Inc.


Seyedin M.Z.,Intelligent Polymer Research Institute | Seyedin M.Z.,Deakin University | Razal J.M.,Intelligent Polymer Research Institute | Razal J.M.,Deakin University | And 3 more authors.
Advanced Functional Materials | Year: 2015

A simple fiber spinning method used to fabricate elastomeric composite fibers with outstanding mechanical performance is demonstrated. By taking advantage of the large size of as-prepared graphene oxide sheets (in the order of tens of micrometers) and their liquid crystalline behavior, elastomeric composite fibers with outstanding low strain properties have been fabricated without compromising their high strain properties. For example, the modulus and yield stress of the parent elastomer improved by 80- and 40-fold, respectively, while maintaining the high extensibility of ∼400% strain inherent to the parent elastomer. This outstanding mechanical performance was shown to be dependent upon the GO sheet size. Insights into how both the GO sheet size dimension and dispersion parameters influence the mechanical behavior at various applied strains are discussed. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.


Yue B.,Donghua University | Yue B.,Intelligent Polymer Research Institute | Wang C.,Intelligent Polymer Research Institute | Ding X.,Donghua University | Wallace G.G.,Intelligent Polymer Research Institute
Electrochimica Acta | Year: 2013

Wearable electronics offer the combined advantages of both electronics and fabrics. Being an indispensable part of these electronics, lightweight, stretchable and wearable power sources are strongly demanded. Here we describe a daily-used cotton fabric coated with polypyrrole as electrode for stretchable supercapacitors. Polypyrrole was synthesized on the Au coated fabric via an electrochemical polymerization process with p-toluenesulfonic acid (p-TS) as dopant from acetonitrile solution. This material was characterized with FESEM, tensile stress, and studied as a supercapacitor electrode in 1.0 M NaCl. This conductive textile electrode can sustain up to 140% strain without electric failure. It delivers a high specific capacitance of 254.9 F g-1 at a scan rate of 10 mV s-1, and keeps almost unchanged at an applied strain (i.e. 30% and 50%) but with an improved cycling stability. © 2013 Elsevier Ltd.

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