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Guo Y.-M.,Chinese Institute of Materia Medica | Li F.-Y.,Treatment and Research Center for Infectious Diseases | Gong M.,Integrative Medical Center for Liver Diseases | Zhang L.,China Pharma | And 6 more authors.
Chinese Journal of Integrative Medicine | Year: 2016

Objective: To evaluate the clinical efficacy and safety of Yinchen Zhufu Decoction (茵陈术附汤, YCZFD) in the treatment of acute-on-chronic liver failure caused by hepatitis B virus (HBV-ACLF) with cold pattern in Chinese medicine (CM). Methods: This is a multi-center randomized controlled trial of integrative treatment of CM and Western medicine (WM) for the management of HBV-ACLF patients. A total of 200 HBV-ACLF patients with cold pattern were equally randomly assigned to receive YCZFD and WM (integrative treatment) or WM conventional therapy alone respectively for 4 weeks. The primary end point was the mortality for HBV-ACLF patients. Secondary outcome measures included Model for End-Stage Liver disease (MELD) score, liver biochemical function, coagulation function and complications. Adverse events during treatment were reported. Results: The mortality was decreased 14.28% in the integrative treatment group compared with WM group (χ2=6.156, P=0.013). The integrative treatment was found to signififi cantly improve the MELD score (t=2.353, P=0.020). There were statistically signififi cant differences in aspartate transaminase, total bilirubin, indirect bilirubin, direct bilirubin and prothrombin time between the two groups (P<0.05 or {vnP}<0.01). The complications of ascites (χ2=9.033, P=0.003) and spontaneous bacteria peritonitis (χ2=4.194, P=0.041) were improved signififi cantly in the integrative treatment group. No serious adverse event was reported. Conclusions: The integrative treatment of CM and WM was effective and safe for HBV-ACLF patients with cold pattern in CM. The Chinese therapeutic principle "treating cold pattern with hot herbs" remains valuable to the clinical therapy. (Trial registration No. ChiCTR-TRC-10000766) © 2016 Chinese Association of the Integration of Traditional and Western Medicine and Springer-Verlag Berlin Heidelberg

Gong M.,School Specialty | Gong M.,Integrative Medical Center for Liver Diseases | Zhang N.,Integrative Medical Center for Liver Diseases | Sun Y.-Q.,Integrative Medical Center for Liver Diseases | And 5 more authors.
Journal of Thermal Analysis and Calorimetry | Year: 2014

The effects of podophyllotoxin (PPT), etoposide (VP16), and teniposide (VM26) on the growth of Tetrahymena thermophila BF5 (T.t.BF 5) was investigated by the TAM AIR isothermal microcalorimetric system. The extent and duration of toxic effects on T.t.BF5 metabolism were evaluated by studying the growth rate constant (k), inhibitory ratio (I), maximum heat-output power (P max), peak time of maximum heat-output power (t p), and total heat production (Q t). Experimental results showed that the value of t p increased and the value of k and P max decreased with the increasing compound concentrations. Furthermore, the growth rate constant k was linear with compound concentration. The corresponding I was obtained from different k values. According to the IC10 (the concentration of inhibitor when the inhibitory ratio is 10 %), the relative toxicity of the three compounds was PPT (IC10 = 49.6 μg mL-1) > VP16 (IC10 = 117.5 μg mL-1) > VM26 (IC10 = 359.1 μg mL -1). The preliminary investigation of structure-activity relationships showed that the thienyl group was likely responsible for reducing the toxicity of the compounds. © 2013 Akadémiai Kiadó, Budapest, Hungary.

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