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dos Santos R.M.,Federal University of Minas Gerais | dos Santos R.M.,Integrated Pharmacology and Drug Interactions Research Group GPqFAR | Dias-Souza M.V.,Federal University of Minas Gerais | Dias-Souza M.V.,Integrated Pharmacology and Drug Interactions Research Group GPqFAR
Saudi Journal of Biological Sciences | Year: 2015

This study aimed to investigate the in vitro antifungal effectiveness of five different formulations against dandruff and ringworm dermatophytes. Candida albicans was also included in our assays. Fungal susceptibility tests were performed with planktonic cells and biofilms of reference strains. Microbiological and physicochemical quality parameters were assessed for all formulations. Our data indicated that the formulations were effective against the dermatophytes strains, and to our knowledge, the effectiveness of cosmetic formulations against fungal biofilms is shown for the first time. The formulations were considered effective against the explored dermatophytes and were considered safe given the adequate microbiological and physicochemical characteristics shown in the proposed assays. © 2015 The Authors.


dos Santos R.,Institute of Business Administration | dos Santos R.,Integrated Pharmacology and Drug Interactions Research Group GPqFAR | Pimenta-Freire G.,Federal University of Minas Gerais | Pimenta-Freire G.,Integrated Pharmacology and Drug Interactions Research Group GPqFAR | And 2 more authors.
International Food Research Journal | Year: 2015

Patients are taking more control over their health, and attracted by contributions to human nutrition, the use of phytonutrients raised. Carotenoids and flavonoids are among the most studied and consumed chemical entities in this sense. However, patients are often unaware of the potential risks associated to drug-herbal interactions. In this study, four drugs were tested combined to lycopene, β-carotene, resveratrol and rutine in an in vitro model against clinical isolates of E. coli and S. aureus. Statistically significant antagonism was detected within most of the tested interactions for at least one isolate. Few events of synergism were detected. For E. coli, the antimicrobial activity of Cephalexin and Amoxicillin was significantly reduced. For S. aureus, strong reduction of the antimicrobial activity was seen for all drugs. Our data suggest that there might be risks of impairment of the antimicrobial activity of these drugs if co-administered with the tested phytonutrients. Further complementary in vivo studies are needed for full assessment of the biological effects of these interactions.


Dos Santos R.,Federal University of Minas Gerais | Dos Santos R.,Integrated Pharmacology and Drug Interactions Research Group GPqFAR | Pimenta-Freire G.,Federal University of Minas Gerais | Figueiredo F.J.B,Santo Agostinho Institute | And 4 more authors.
International Food Research Journal | Year: 2016

The use of phytonutrients in pharmaceutical dosage forms aiming a healthier lifestyle has increased worldwide, and in spite of being generally an useful healthcare measure, this is not free of risks when concomitant medication use is considered. The combined use of phytonutrients and medication remains poorly investigated, and represents a serious problem in drug therapy, given that side effects due to drug-nutrient interactions are poorly predictable. In this study, three drugs were tested in combination to lycopene β-carotene (carotenoids), diosmin and curcumin (flavonoids) against clinical isolates of P. aeruginosa. Strains identity was confirmed by automated methods and the interference of phytomolecules on the pharmacological activity of the chosen drugs was assessed in vitro using antimicrobial disks. Here we show that lycopene, β-carotene, diosmin and curcumin can act synergistically when combined to antimicrobial drugs against clinical isolates of P. aeruginosa. In vivo studies are necessary for assessing the biological effects of these interactions considering clinical contexts. © All Rights Reserved.

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