Chen W.,Integrated Biosystems and Biomechanics Laboratory |
Weng S.,Integrated Biosystems and Biomechanics Laboratory |
Zhang F.,Integrated Biosystems and Biomechanics Laboratory |
Zhang F.,CAS Shanghai Institute of Microsystem and Information Technology |
And 6 more authors.
Circulating tumor cells (CTCs) detached from both primary and metastatic lesions represent a potential alternative to invasive biopsies as a source of tumor tissue for the detection, characterization and monitoring of cancers. Here we report a simple yet effective strategy for capturing CTCs without using capture antibodies. Our method uniquely utilized the differential adhesion preference of cancer cells to nanorough surfaces when compared to normal blood cells and thus did not depend on their physical size or surface protein expression, a significant advantage as compared to other existing CTC capture techniques. © 2012 American Chemical Society. Source