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Betsou F.,IBBL Integrated Biobank of Luxembourg | Gunter E.,Specimen Solutions LLC | Clements J.,Queensland University of Technology | De Souza Y.,University of California at San Francisco | And 7 more authors.
Journal of Molecular Diagnostics | Year: 2013

Control of biospecimen quality that is linked to processing is one of the goals of biospecimen science. Consensus is lacking, however, regarding optimal sample quality-control (QC) tools (ie, markers and assays). The aim of this review was to identify QC tools, both for fluid and solid-tissue samples, based on a comprehensive and critical literature review. The most readily applicable tools are those with a known threshold for the preanalytical variation and a known reference range for the QC analyte. Only a few meaningful markers were identified that meet these criteria, such as CD40L for assessing serum exposure at high temperatures and VEGF for assessing serum freeze-thawing. To fully assess biospecimen quality, multiple QC markers are needed. Here we present the most promising biospecimen QC tools that were identified. Copyright © 2013 American Society for Investigative Pathology and the Association for Molecular Pathology. Source


Betsou F.,IBBL Integrated Biobank of Luxembourg
Biopreservation and Biobanking | Year: 2014

This report makes the case for clinical biospecimens to be certified for nominal properties, in particular the diagnosis, and to attain the level of Reference Materials. Clinical certified biospecimens that are collected, processed, characterized, stored, and distributed by biobanks are urgently needed to facilitate diagnostic test development, evaluation, and quality assurance. Four examples are provided to illustrate this purpose and the certification approaches that could be applied are proposed. © Copyright 2014, Mary Ann Liebert, Inc. 2014. Source

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