Lucknow, India
Lucknow, India

Integral University is a State Private University in Lucknow, the capital of Uttar Pradesh, India, which was established as a university from Institute of Integral Technology, Lucknow under Act Number 9 of 2004 by the Uttar Pradesh state government. The Institute of Integral Technology, Lucknow was established in 1998 by the then Prime Minister of India Mr. Atal Bihari Vajpayee. Wikipedia.

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Shakya P.,Integral University | Madhav N.V.S.,Dehradoon Institute of Technology | Shakya A.K.,Al-Ahliyya Amman University | Singh K.,Integral University
Journal of Controlled Release | Year: 2011

Rapid developments in the field of molecular biology and gene technology resulted in generation of many macromolecular drugs including peptides, proteins, polysaccharides and nucleic acids in great number possessing superior pharmacological efficacy with site specificity and devoid of untoward and toxic effects. However, the main impediment for the oral delivery of these drugs as potential therapeutic agents is their extensive pre-systemic metabolism, instability in acidic environment resulting into inadequate and erratic oral absorption. Parenteral route of administration is the only established route that overcomes all these drawbacks associated with these orally less/inefficient drugs. But, these formulations are costly, have least patient compliance, require repeated administration, in addition to the other hazardous effects associated with this route. Over the last few decades pharmaceutical scientists throughout the world are trying to explore transdermal and transmucosal routes as an alternative to injections. Historically, oral transmucosal drug delivery has received intensive interest since ancient times for the most widely utilized route of administration for the systemic delivery of drugs. In more recent years, better systemic bioavailability of many drugs has been achieved by oromucosal route. Among the various transmucosal sites available, soft-palatal mucosa was also found to be the most convenient and easily accessible novel site for the delivery of therapeutic agents for systemic delivery as retentive dosage forms, because it has abundant vascularization and rapid cellular recovery time after exposure to stress. Smooth surface of the soft palate and its good flexibility are prerequisites to prevent mechanical irritation and local discomfort. The objective of this review is to provide an update on the most promising advances in novel non-invasive soft-palatal route and the conceptual and technical approaches to the design and formulation of soft-palatal drug delivery systems. In this area, the development of mucoadhesive delivery systems appears to be the most promising strategy. © 2010 Elsevier B.V.

Maurya S.,Integral University | Singh D.,IET
International Journal of PharmTech Research | Year: 2010

Adhatoda vasica leaves were analyzed for total phenolic contents. This phenolic component is responsible for antioxidant activity. The amount of total phenols were analyzed with the Folin-Ciocalteu reagent. Gallic acid was used as a standard compound and the total phenols were expressed as mg/g gallic acid equivalents (standard curve equation: y = 0.0061x + 0.0396, R2= 0.9991). The total phenol varied from 63.95±2.1 to 92.4±0.14 mg/g in the extracts. The maximum phenolic content was found in the aqueous extract (92.4±0.14 mg/g).

Maurya S.,Integral University
AIP Conference Proceedings | Year: 2016

Quality of MOS devices is a strong function of substrate and oxide interface. In this work we have studied how gamma photon irradiation affects the interface of a 13 nm thick, atomic layer deposited hafnium dioxide deposited on silicon wafer. CV and GV measurements have been done for pristine and irradiated samples to quantify the effect of gamma photon irradiation. Gamma photon irradiation not only introduces positive charge in the oxide and at the interface of Si/HfO2 interface but also induce phase change of oxide layer. Maximum oxide capacitances are affected by gamma photon irradiation. © 2016 Author(s).

Maurya S.,Integral University
Journal of Materials Science: Materials in Electronics | Year: 2017

The performance of electronic devices and systems get degraded when they are exposed to radiation above a certain limit or over longer duration and the process is called radiation damage. The performance degradation is due to the damage caused to the interface by the radiation. The damage takes place in the form of dangling or unsatisfied bonds and, trapped charges, formed at the interface. Interfaces and surfaces cannot be ignored and are indispensable in many problems like creation of numerous semiconductor junctions while forming devices, in chemical reactions, intricate biological reactions and processes, and corrosions of material surfaces etc. Substrate surfaces and interface of substrates and oxides play a key role in the performance of the metal oxide/insulator semiconductor field effect transistor and various other similar types of devices. Surfaces are abrupt termination of one material and formation of a second material so the surfaces may have unsaturated chemical bonds forming chemically active surfaces. Even after growing a thin layer of other required material over it, all the unsaturated chemical bonds are not satisfied. Later these surfaces with unsaturated bonds play an important role in the performance reliability of the semiconductor devices. Annealing is one of the processes that is used to modify these unsaturated dangling bonds. This investigation is to explore the possibility of interface modification by alpha particle irradiation, after the fabrication of the interfaces/devices. Here we present a method to improve the interface of silicon and hafnium dioxide, through alpha particle irradiation. This method can be used to improve the interface quality even after fabrication process is over. © 2017 Springer Science+Business Media, LLC

Rahman M.A.,Integral University | Hussain A.,Integral University
Bangladesh Journal of Pharmacology | Year: 2015

MTT assay and DAPI staining test were performed to evaluate anticancer potential and to assess apoptosis inducing effect of methanolic extract of Cordia dichotoma leaves (MECD) against human cervical cancer cell line (HeLa). Changes in MMP and intracellular ROS level were also assessed by JC-1 and DCFH-DA staining. Total phenolic contents were determined by colorimetric principle. Levels of statistical significance were determined by one-way analysis of variance followed by Dunnett’s posttest. Results showed that MECD with obtained IC50 of 202 µg/mL inhibited in vitro proliferation of human cervical cancer cells and induced apoptosis indicating its promising anticancer activity as compared to the standard tamoxifen with obtained IC50of 48 µg/mL. Total phenolic contents was found to be 176.5 mg GAE/g dried extract. It was concluded that MECD possess promising anticancer activity and induce apoptosis. © 2015 Bangladesh Pharmacological Society. All Rights reserved.

Jawaid T.,Hygia Institute of Pharmaceutical Education and Research | Jahan S.,Hygia Institute of Pharmaceutical Education and Research | Kamal M.,Integral University
Journal of Advanced Pharmaceutical Technology and Research | Year: 2015

The comparative study of neuroprotective effect of angiotensin converting enzyme inhibitors against scopolamine-induced neuroinflammation in albino Wistar rats was studied. Male albino rats were administered with scopolamine to induce memory impairment. The standard nootropic agent, piracetam (200 mg/kg b.w., [i.p.]), perindopril (0.1 mg/kg b.w., [i.p.]), enalapril (0.1 mg/kg b.w., [i.p.]), and ramipril (0.1 mg/kg b.w., [i.p.]) were administered in different group of animals for 5 days. On 5 th day, scopolamine (1 mg/kg b.w., i.p.) was administered after 60 min of the last dose of test drug. Memory function was evaluated in Morris water maze (MWM) test and pole climbing test (PCT). Biochemical estimations like glutathione (GSH), malondialdehyde (MDA), and acetylcholinesterase activity in the brain were estimated after completion of behavior study. All three test groups shows improvement in learning and memory in comparison to control group. Perindopril treated group showed a more effective significant decrease in escape latency time and transfer latency time compared to enalapril and ramipril treated group on day 4 in MWM test and PCT, respectively. Perindopril shows a significant reduction in MDA level and acetylcholinesterase activity and a significant rise in GSH level compared to enalapril and ramipril. The finding of this study indicates that Perindopril is more effective in memory retention compared to enalapril and ramipril.

Kuddus M.,Integral University | Kuddus M.,Shaqra University | Ramteke P.W.,SHIATS
Critical Reviews in Microbiology | Year: 2012

Microbial proteases that occupy a pivotal position with respect to their commercial applications are most important hydrolytic enzymes and have been studied extensively since the advent of enzymology. Cold-adapted microorganisms are potential source of cold-active proteases and they have been isolated from the cold regions. Although there are many microbial sources available for producing proteases, only few are recognized as commercial producer. Cold-active proteases along with their producing microbes are of commercial value and find multiple applications in various industrial and biotechnological sectors such as additives in detergents, additives in food industries, environmental bioremediations, biotransformation and molecular biology applications. Therefore, cold-active proteases are the enzymes of choice for many biotechnologists, microbiologists, biochemists, environmentalists and biochemical engineers. In the present review, we discuss some novel sources along with recent developments in production and biotechnological applications of cold-active microbial proteases. © 2012 Informa Healthcare USA, Inc.

Rahman Q.I.,Integral University | Ahmad M.,Indian Institute of Technology Kanpur | Misra S.K.,DAV College Kanpur | Lohani M.,Integral University
Materials Letters | Year: 2013

Highly crystalline ZnO nanoparticles (NPs) were synthesized with zinc acetate as precursor and oxalic acid at 80°C through the simple solution phase approach. The synthesized ZnO NPs possessed monodispersity with the average size 20-30 nm. The crystalline properties revealed the typical hexagonal wurtzite phase with orientation along c-axis. The photocatalytic activity investigation was carried out by performing the decomposition of rhodamine-B dye under UV illumination over as-synthesized ZnO NPs. The rhodamine B dye considerably degraded by ∼95 within 70 min in the presence of as-synthesized ZnO NPs. An excellent rate constant (k=0.0343 min-1) was obtained for the degradation of rhodamine B dye. © 2012 Elsevier B.V. All rights reserved.

Hussain M.S.,Integral University
African Journal of Traditional, Complementary and Alternative Medicines | Year: 2011

Many people have the mistaken notion that, being natural, all herbs and foods are safe; this is not so. Very often, herbs and food may interact with medications you normally take, result in serious reactions. During the latter part of this century the practice of herbalism has become mainstream throughout the world. This is due remove to the recognition of the value of traditional medical systems in the world. Herbal medicines are mixtures of more than one active ingredient. The multitude of pharmacologically active compounds obviously increases the likelihood of interactions taking place. Hence, the likelihood of herb-drug interactions is theoretically higher than drug-drug interactions because synthetic drugs usually contain single chemical entity. Case reports and clinical studies have highlighted the existence of a number of clinically important interactions, although cause-and-effect relationships have not always been established. Herbs and drugs may interact either pharmacokinetically or pharmacodynamically. The predominant mechanism for this interaction is the inhibition of cytochrome P-450 3A4 in the small intestine; result in a significant reduction of drug presystemic metabolism. An additional mechanism is the inhibition of Pglycoprotein, a transporter that carries drug from the enterocyte back to the gut lumen, result in a further increase in the fraction of drug absorbed. Some herbal products (e.g. St. John's wort) have been shown to lower the plasma concentration (and/or the pharmacological effect) of a number of conventional drugs including cyclosporine, indinavir, irinotecan, nevirapine, oral contraceptives and digoxin. The data available so far, concerning this interaction and its clinical implications are reviewed in this article. It is likely that more information regarding such interaction would crop up in the future, awareness of which is necessary for achieving optimal drug therapy. © African Journal of Traditional, Complementary and Alternative Medicines.

Usmani S.,Integral University
Asian Journal of Pharmaceutical and Clinical Research | Year: 2013

Calotropis gigantea L, belonging to family: Asclepiadaceae is also known as Sweat akand, is used in traditional medicine for treatment of various ailments. The surface microscopy of leaf was performed along with powder microscopy. Leaf and flower extracts of Calotropis gigantea were prepared by using various solvents like Acetone, Chloroform and Methanol in increasing polarity. The reference drug used was Silymarin. Antioxidant activity was studied by DPPH method.The level of percentage inhibition was found to be more in the Methanolic extract(64%). Since no such work has been investigated and reported in detail earlier, therefore an effort has been made to explore the antioxidant activity in this plant.

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