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Aggarwal R.,Sharda Hospital | Gupta O.,Safdarjung Hospital | Yadav Y.,Integral Institute of Medical science and Research | Dogra S.,Safdarjung Hospital
International Journal of Trichology | Year: 2013

Cylindroma is a benign adnexal tumor, which occurs as solitary dermal nodules on the scalp and forehead. Cylindroma of the breast is a rare lesion. Fine-needle aspiration is often the first line of investigation. In this communication, we illustrate the cytomorphological feature of cylindroma in a 61-year-old female patient who presented with a breast lump. Fine-needle aspiration cytology in this case reveals the islands of tumor cells formed a jig-saw pattern, along with the bland, basaloid cells associated with globular, extracellular material. These features are typical of cylindroma, but differential diagnosis of adenoidcystic carcinoma should always be kept in mind as the management of both tumors are different.


Yadav Y.K.,Integral Institute of Medical science and Research | Kushwaha R.,University of Lucknow | Sharma U.,VMMC and Safdarjung Hospital | Gupta K.,VMMC and Safdarjung Hospital
Journal of Cytology | Year: 2013

Pleomorphic fibroma (PF) is a benign, polypoid, or dome?shaped cutaneous neoplasm with cytologically atypical fibrohistiocytic cells. We describe the cytomorphological features of PF retrospectively with histopathological diagnosis in a 38-year-old male who presented with 3 × 1.5 cm swelling in the soft tissues of the thigh for 6 months. This lesion is benign despite the presence of pleomorphic or bizarre cells. We review the differential diagnosis of PF with other mesenchymal tumors. To the best of our knowledge, cytomorphological features on fine needle aspiration cytology of this tumor are not yet documented in literature.


Tripathi A.,University of Lucknow | Tekkalaki B.,Jawaharlal Nehru Medical College | Agarwal A.,Integral Institute of Medical science and Research
South African Journal of Psychiatry | Year: 2015

Genital self-mutilation (GSM) is a rare phenomenon. In the majority of cases, GSM is secondary to psychotic illness. Among the nonpsychotics, the motives behind GSM are varied. We report a rare case in which a non-psychotic, non-paraphilic patient suffering from excessive sexual drive carried out GSM to curb hypersexuality. Aetiological factors behind GSM are discussed. This case report emphasises that excessive sexual drive may lead to distress and GSM. Effective management of excessive sexual drive and active inquiry into any intentions of GSM in such patients may be helpful in preventing GSM. © S Afr J Psychiatr. All rights reserved.


Shruti D.,Safdarjung Hospital and Vardhman Mahavir Medical College | Kumar Y.Y.,Integral Institute of Medical Science and Research | SharM.A. U.,Safdarjung Hospital and Vardhman Mahavir Medical College | Gupta K.,Safdarjung Hospital and Vardhman Mahavir Medical College
International Journal of Trichology | Year: 2012

Rapunzel syndrome is a rare type of presentation of trichobezoar, an extension of hair fibers into the small bowel and rarely beyond the ileocecal valve. Its clinical presentation is deceptive ranging from abdominal mass to symptoms of obstruction. We report a 8-year-old girl admitted with a history of abdominal pain and vomiting off and on for a period of 1 year. Ultrasound findings were suggestive of subacute intestinal obstruction. On laparotomy, trichobezoar was found in the stomach extending into small bowel and was removed. Appendix was inflammed hence it was also resected. Microscopic evidence of a hair shaft was seen in the appendix indicating appendicitis was due to luminal obstruction by hair concretions.


Nigar A.,Integral Institute of Medical science and Research | Yadav Y.K.,Integral Institute of Medical science and Research | Hakim S.,Jawahar Lal Nehru Medical College
Journal of Clinical and Diagnostic Research | Year: 2015

Endometrial ossification is a rare entity in which bones are found in the uterus. Exact aetiopathogenesis is not known but the most accepted theory is metaplasia of stromal cells into osteoblast cells result in the formation of bones. The possibility of malignant mixed mullerian tumour should be in the mind of clinician and pathologist while making diagnosis. We hereby report an extremely rare case, which is among very few reported cases in the world, in which endometrial ossification presented in a perimenopausal female with polymenorrhagia. A 41-year-old multiparous patient presented with irregular bleeding per vaginum for the past two years. She was found to be a case of endometrial calcification with osseous metaplasia with presence of bones varying from 7mm - 1.5 cms size in the uterine cavity. She was successfully managed by total abdominal hysterectomy. © 2015, Journal of Clinical and Diagnostic Research. All rights reserved.


Tiwari N.,Eras Lucknow Medical College and Hospital | Singh S.,Integral Institute Of Medical science and Research | Tiwari S.,University of Lucknow
International Journal of Pharma and Bio Sciences | Year: 2015

Stress is a non specific response of the body, when exposed to any demanding situation. A slight increase in cortisol levels,cortisol being the major stress hormone implicated in stress, has positive effects like increased energy, increased memory and decreased pain sensitivity.However, prolonged increase in cortisol levels can disrupt blood sugar metabolism, trigger emotional problems and elicit a feeling of constant weakness and tiredness. Salivary cortisol level measurement is a valuable and convenient alternative to plasma cortisol estimation. Even though people suffering from more stress than average have higher cortisol levels, it is yet to be demonstrated in natural conditions and in different phase of life.In our study,we studied the association of salivary cortisol with stress in different phases of the menstrual cycle and we concluded that salivary cortisol levels show positive correlation with luteal phase of menstrual cycle.


PubMed | Integral Institute of Medical science and Research and University of Lucknow
Type: Journal Article | Journal: Journal of clinical and diagnostic research : JCDR | Year: 2016

Chediak-Higashi syndrome (CHS) is an uncommon and fatal congenital disorder. The characteristic features of CHS are partial oculocutaneous albinism, increased vulnerability to infections, presence of abnormal large granules in leukocytes and an accelerated lymphohistiocytic phase. Accelerated phase at initial presentation is rarely seen as it is usually preceded by repeated episodes of infections. Hence this interesting case of a four-month-old Indian child born to consanguineous parents in accelerated phase at initial presentation is described. The boy presented with fever, hepatosplenomegaly, and cleft lip. Clinical diagnosis was leukemia or a lysosomal storage disorder. Cytopaenias, lymphohistiocytic infiltration in bone marrow, and the characteristic large granules in leucocytes helped in the diagnosis, emphasizing the importance of bone marrow in diagnosis of unusual presentation of this rare disorder.


PubMed | Integral Institute of Medical science and Research
Type: Journal Article | Journal: Anesthesia, essays and researches | Year: 2016

Clinical need for a nondepolarizing agent with a rapid onset time and a brief duration of action has led to the development of rocuronium bromide.The aim of this study was to evaluate optimal dose of rocuronium bromide for intubation and to compare the onset time, duration of action, intubating conditions, and hemodynamic effects of two doses of rocuronium bromide.A prospective, randomized, double-blind study.All the patients were divided in a randomized, double-blind fashion into two groups of twenty patients each. Group I patients received rocuronium bromide 0.6 mg/kg intravenously and intubated at 60 s, Group II patients received rocuronium bromide 0.9 mg/kg and intubated at 60 s. The neuromuscular block was assessed using single twitch stimulation of 0.1 Hz at adductor pollicis muscle of hand at every 10 s.The results were compiled and analyzed statistically using Chi-square test for qualitative data and Students Time of onset was significantly shorter (Rocuronium bromide 0.9 mg/kg is a safer alternative to rocuronium bromide 0.6 mg/kg for endotracheal intubation with shorter time of onset and better intubating conditions.


PubMed | Integral Institute of Medical science and Research and Jawahar Lal Nehru Medical College
Type: Journal Article | Journal: Journal of clinical and diagnostic research : JCDR | Year: 2015

Endometrial ossification is a rare entity in which bones are found in the uterus. Exact aetiopathogenesis is not known but the most accepted theory is metaplasia of stromal cells into osteoblast cells result in the formation of bones. The possibility of malignant mixed mullerian tumour should be in the mind of clinician and pathologist while making diagnosis. We hereby report an extremely rare case, which is among very few reported cases in the world, in which endometrial ossification presented in a perimenopausal female with polymenorrhagia. A 41-year-old multiparous patient presented with irregular bleeding per vaginum for the past two years. She was found to be a case of endometrial calcification with osseous metaplasia with presence of bones varying from 7mm - 1.5 cms size in the uterine cavity. She was successfully managed by total abdominal hysterectomy.


PubMed | King Saud University and Integral Institute of Medical science and Research
Type: | Journal: Histology and histopathology | Year: 2016

Recently, gold nanoparticles (GNPs) have shown promising applications in targeted drug delivery and contrast imaging. Although in vitro cytotoxicity of GNPs has been thoroughly studied, there are limited data on in vivo toxicity of GNPs. In this study, we evaluated the effects of intraperitoneally injected 10 nm and 50 nm GNPs (5 g/animal) on the expression of proinflammatory cytokines (IL-1, IL-6 and TNF-) on day 1 and day 5, post-exposure. The results of immunohistochemistry showed that both 10 nm and 50 nm GNPs induced an acute phase expression of proinflammatory cytokines in renal cortex and medulla. This proinflammatory response was comparatively more intense in renal medulla than cortex. All the three cytokines were undetectable in control cortex and medulla. In conclusion, both 10 nm and 50 nm GNPs caused an acute phase induction of proinflammatory cytokines in cortex and medulla of rat kidneys. An intense immunostaining of proinflammatory cytokines in renal medulla warrants further studies to evaluate the nephrotoxicity of GNPs to validate the safe application of GNPs for contrast imaging in renal insufficiency.

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