Integral Institute of Medical science and Research

Lucknow, India

Integral Institute of Medical science and Research

Lucknow, India
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Gupta P.,Integral Institute of Medical science and Research | Bharati N.,Integral Institute of Medical science and Research | Hussein M.,P.A. College | Singh A.B.,University of Lucknow
Journal of the Anatomical Society of India | Year: 2017

Introduction: The mandibular foramen is a prominent feature on the medial surface of the ramus of the mandible which is located just above its center. The dental surgeon who is going to perform a surgery in oral cavity, tooth extraction should be aware of accessory mandibular foramina for planning to give anesthesia at an appropriate anatomical site as the branches of facial, mylohyoid, buccal and transverse cervical cutaneous nerves are known to pass through these foramina. Methods: The present current study was carried out on 50 human dry North Indian mandibles in which 45 were dentulous and 5 edentulous. The measurements were obtained with sliding caliper as per standard anthropological conventions. Results: We observed that the mandibular foramen was positioned at a mean distance of 19. mm with SD 2.34 from coronoid notch of the anterior border of the ramus. It was found in this study that the location of mandibular foramen is not at the center of mandibular ramus in the horizontal plane, it is situated at a distance of 2.75. mm posterior to the midpoint of antero posterior width of ramus of mandible. Discussion: Knowledge of the position of mandibular foramen is very importance for many procedures in dentistry and useful for the maxillofacial surgeons, radiologists and oncologists in preventing neurovascular complications and misinterpretations. © 2017 Anatomical Society of India.


Ibrahim K.E.,King Saud University | Khan A.,Integral Institute of Medical science and Research
Histology and Histopathology | Year: 2017

Recently, gold nanoparticles (GNPs) have shown promising applications in targeted drug delivery and contrast imaging. Although in vitro cytotoxicity of GNPs has been thoroughly studied, there are limited data on in vivo toxicity of GNPs. In this study, we evaluated the effects of intraperitoneally injected 10 nm and 50 nm GNPs (5 µg/animal) on the expression of proinflammatory cytokines (IL-1β, IL-6 and TNF-α) on day 1 and day 5, post-exposure. The results of immunohistochemistry showed that both 10 nm and 50 nm GNPs induced an acute phase expression of proinflammatory cytokines in renal cortex and medulla. This proinflammatory response was comparatively more intense in renal medulla than cortex. All the three cytokines were undetectable in control cortex and medulla. In conclusion, both 10 nm and 50 nm GNPs caused an acute phase induction of proinflammatory cytokines in cortex and medulla of rat kidneys. An intense immunostaining of proinflammatory cytokines in renal medulla warrants further studies to evaluate the nephrotoxicity of GNPs to validate the safe application of GNPs for contrast imaging in renal insufficiency. © 2017, Histology and Histopathology. All rights reserved.


Jaiswal P.,Integral Institute of Medical science and Research | Yadav Y.K.,Integral Institute of Medical science and Research | Jaiswal S.,KGMU | Bhasker N.,Integral Institute of Medical science and Research
Journal of Parasitic Diseases | Year: 2017

Isolated cysticercosis of anterior abdominal wall without parasitosis of central nervous system is very rare and may mimic a tumor leading to diagnostic and therapeutic dilemma. Histopathological examination plays an important role in making a definitive diagnosis. Here we report a case of a 13-year old Muslim girl presenting with swelling and pain in left lower abdomen which was clinically diagnosed as lipoma. On histopathological examination cysticercus with surrounding inflammation was seen. Since cysticercosis is a preventable disease, early and accurate diagnosis is necessary for the reduction of disease burden in the endemic areas. © 2016, Indian Society for Parasitology.


Aggarwal R.,Sharda Hospital | Gupta O.,Safdarjung Hospital | Yadav Y.,Integral Institute of Medical science and Research | Dogra S.,Safdarjung Hospital
International Journal of Trichology | Year: 2013

Cylindroma is a benign adnexal tumor, which occurs as solitary dermal nodules on the scalp and forehead. Cylindroma of the breast is a rare lesion. Fine-needle aspiration is often the first line of investigation. In this communication, we illustrate the cytomorphological feature of cylindroma in a 61-year-old female patient who presented with a breast lump. Fine-needle aspiration cytology in this case reveals the islands of tumor cells formed a jig-saw pattern, along with the bland, basaloid cells associated with globular, extracellular material. These features are typical of cylindroma, but differential diagnosis of adenoidcystic carcinoma should always be kept in mind as the management of both tumors are different.


Yadav Y.K.,Integral Institute of Medical science and Research | Kushwaha R.,University of Lucknow | Sharma U.,VMMC and Safdarjung Hospital | Gupta K.,VMMC and Safdarjung Hospital
Journal of Cytology | Year: 2013

Pleomorphic fibroma (PF) is a benign, polypoid, or dome?shaped cutaneous neoplasm with cytologically atypical fibrohistiocytic cells. We describe the cytomorphological features of PF retrospectively with histopathological diagnosis in a 38-year-old male who presented with 3 × 1.5 cm swelling in the soft tissues of the thigh for 6 months. This lesion is benign despite the presence of pleomorphic or bizarre cells. We review the differential diagnosis of PF with other mesenchymal tumors. To the best of our knowledge, cytomorphological features on fine needle aspiration cytology of this tumor are not yet documented in literature.


Tiwari N.,Eras Lucknow Medical College and Hospital | Singh S.,Integral Institute Of Medical science and Research | Tiwari S.,University of Lucknow
International Journal of Pharma and Bio Sciences | Year: 2015

Stress is a non specific response of the body, when exposed to any demanding situation. A slight increase in cortisol levels,cortisol being the major stress hormone implicated in stress, has positive effects like increased energy, increased memory and decreased pain sensitivity.However, prolonged increase in cortisol levels can disrupt blood sugar metabolism, trigger emotional problems and elicit a feeling of constant weakness and tiredness. Salivary cortisol level measurement is a valuable and convenient alternative to plasma cortisol estimation. Even though people suffering from more stress than average have higher cortisol levels, it is yet to be demonstrated in natural conditions and in different phase of life.In our study,we studied the association of salivary cortisol with stress in different phases of the menstrual cycle and we concluded that salivary cortisol levels show positive correlation with luteal phase of menstrual cycle.


PubMed | Integral Institute of Medical science and Research and University of Lucknow
Type: Journal Article | Journal: Journal of clinical and diagnostic research : JCDR | Year: 2016

Chediak-Higashi syndrome (CHS) is an uncommon and fatal congenital disorder. The characteristic features of CHS are partial oculocutaneous albinism, increased vulnerability to infections, presence of abnormal large granules in leukocytes and an accelerated lymphohistiocytic phase. Accelerated phase at initial presentation is rarely seen as it is usually preceded by repeated episodes of infections. Hence this interesting case of a four-month-old Indian child born to consanguineous parents in accelerated phase at initial presentation is described. The boy presented with fever, hepatosplenomegaly, and cleft lip. Clinical diagnosis was leukemia or a lysosomal storage disorder. Cytopaenias, lymphohistiocytic infiltration in bone marrow, and the characteristic large granules in leucocytes helped in the diagnosis, emphasizing the importance of bone marrow in diagnosis of unusual presentation of this rare disorder.


PubMed | Integral Institute of Medical science and Research
Type: Journal Article | Journal: Anesthesia, essays and researches | Year: 2016

Clinical need for a nondepolarizing agent with a rapid onset time and a brief duration of action has led to the development of rocuronium bromide.The aim of this study was to evaluate optimal dose of rocuronium bromide for intubation and to compare the onset time, duration of action, intubating conditions, and hemodynamic effects of two doses of rocuronium bromide.A prospective, randomized, double-blind study.All the patients were divided in a randomized, double-blind fashion into two groups of twenty patients each. Group I patients received rocuronium bromide 0.6 mg/kg intravenously and intubated at 60 s, Group II patients received rocuronium bromide 0.9 mg/kg and intubated at 60 s. The neuromuscular block was assessed using single twitch stimulation of 0.1 Hz at adductor pollicis muscle of hand at every 10 s.The results were compiled and analyzed statistically using Chi-square test for qualitative data and Students Time of onset was significantly shorter (Rocuronium bromide 0.9 mg/kg is a safer alternative to rocuronium bromide 0.6 mg/kg for endotracheal intubation with shorter time of onset and better intubating conditions.


PubMed | Integral Institute of Medical science and Research and Jawahar Lal Nehru Medical College
Type: Journal Article | Journal: Journal of clinical and diagnostic research : JCDR | Year: 2015

Endometrial ossification is a rare entity in which bones are found in the uterus. Exact aetiopathogenesis is not known but the most accepted theory is metaplasia of stromal cells into osteoblast cells result in the formation of bones. The possibility of malignant mixed mullerian tumour should be in the mind of clinician and pathologist while making diagnosis. We hereby report an extremely rare case, which is among very few reported cases in the world, in which endometrial ossification presented in a perimenopausal female with polymenorrhagia. A 41-year-old multiparous patient presented with irregular bleeding per vaginum for the past two years. She was found to be a case of endometrial calcification with osseous metaplasia with presence of bones varying from 7mm - 1.5 cms size in the uterine cavity. She was successfully managed by total abdominal hysterectomy.


PubMed | King Saud University and Integral Institute of Medical science and Research
Type: | Journal: Histology and histopathology | Year: 2016

Recently, gold nanoparticles (GNPs) have shown promising applications in targeted drug delivery and contrast imaging. Although in vitro cytotoxicity of GNPs has been thoroughly studied, there are limited data on in vivo toxicity of GNPs. In this study, we evaluated the effects of intraperitoneally injected 10 nm and 50 nm GNPs (5 g/animal) on the expression of proinflammatory cytokines (IL-1, IL-6 and TNF-) on day 1 and day 5, post-exposure. The results of immunohistochemistry showed that both 10 nm and 50 nm GNPs induced an acute phase expression of proinflammatory cytokines in renal cortex and medulla. This proinflammatory response was comparatively more intense in renal medulla than cortex. All the three cytokines were undetectable in control cortex and medulla. In conclusion, both 10 nm and 50 nm GNPs caused an acute phase induction of proinflammatory cytokines in cortex and medulla of rat kidneys. An intense immunostaining of proinflammatory cytokines in renal medulla warrants further studies to evaluate the nephrotoxicity of GNPs to validate the safe application of GNPs for contrast imaging in renal insufficiency.

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