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Warzocha K.,Instytut Hematologii i Transfuzjologii
Hematologia | Year: 2013

This article describes the project of a national network for oncology in Poland based on comprehensive cancer centres and institutes, in particular the role played by the National Institute of Oncology and Hematology. © 2013 Via Medica. Source


Classical Hodgkin lymphoma (cHL) is characterized by pathognomonic Reed-Sternberg (R-S) cells, surrounded by an extensive infiltrate of T- and B-lymphocytes, granulocytes, macrophages, plasma cells, eosinophils, mast cells and fibroblasts. This peculiar infiltrate exhibits profoundlocal immunosuppressive properties and extensive network of mutual connections with R-S cells. Chemokines, cytokines and immunomodulatory proteins produced and released by R-S cells directly skew T-cell compartment toward Th2 and Treg cells, and induce infiltration of other cellular components that support R-S cell proliferation. Microenvironment-induced activation of R-S cell surface tumor necrosis factor-family receptors, cytokine receptors and Notch-1 signaling trigger activation of transcription nuclear factor κB (NFκB), JAK-STAT axis and suppression of B-cell transcriptional program. Understanding of these complex relationships led to conceptual design of targeted therapeutic interventions that by selective inhibition of receptor signaling, depletion of microenvironment cellular components or immunomo-dulation can deprive R-S cells from their supportive niche and complement conventional chemotherapy or R-S-cell-targeted drugs. The presented manuscript summarizes current views on the role of microenvironment in cHL, emphasizes its potential therapeutic applications. © 2011 Via Medica. Source


Kraj M.,Instytut Hematologii i Transfuzjologii
Acta Haematologica Polonica | Year: 2011

Present status of knowledge on etiology, clinic and therapy of plasma cell leukemia is presented in this paper. Source


Warzocha K.,Instytut Hematologii i Transfuzjologii
Nowotwory | Year: 2014

This article describes an operational model for the national oncology network in Poland based on standardised diagnostic and treatment working practices performed accordingly to defioned levels of referentiality and competence, at certified medical centres that are covered by the national health fund. Source


Internal hernia results from viscus protrusion into a retroperitoneal fossa or foramen in the abdominal cavity. The condition is rare but when it occurs the patient usually manifests symptoms of alimentary tract obstruction. In this paper we present a very rare case of post-operative incarcerated internal hernia. On post-operative day four we diagnosed small bowel obstruction in a patient subjected to left side nephroctomy from retroperitoneal access. Emergency surgical procedure followed. The incarcerated intestinal hernia was released from the inferior ileocecal recess and absorbable sutures were applied. The post operative complications (pneumonia in right lung and bacterial wound infection) subsided as result of antibiotic therapy and wound dressing Following successful medical treatment, the patient was discharged (postoperative day 20). Diagnosis of incarcerated hernia of the interior ileocecal recess is not easy and often occurs incidentally during exploratory laparoscopy for intestinal occlusion. Source

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