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Rajabi M.,University of Piemonte Orientale | Rajabi M.,University of Milan | Rajabi M.,University of Milan Bicocca | Gorincioi E.,University of Milan | And 2 more authors.
Nucleosides, Nucleotides and Nucleic Acids | Year: 2012

Cytokinins and cytokinin nucleosides are purine derivatives with potential anticancer activity both in vitro and in vivo. N6-furfuryladenosine (kinetin riboside, KR) displays antiproliferative and apoptogenic activity against various human cancer cell lines and has recently been shown to suppress tumor growth in murine xenograft models of human leukemia and melanoma. In this study, we demonstrate that KR is able to inhibit the proliferation in HCT-15 human colon cancer cells in a dose-dependent manner with a concentration of 2.5 ̀M, which causes 50% inhibition of cell viability. The cell cycle analysis by flow cytometry showed that KR arrested cell cycle progression in the S Phase by blocking through G2/M and G0/G1 phase in HCT-15 colon cells. Moreover, suppression of clonogenic activity occurs after exposure to KR at a concentration of 2.5 μM for HCT-15. Copyright © Taylor and Francis Group, LLC.


Ungur N.,Institutul Of Chimie Al Academiei Of Stiinte A Moldovei | Kulcitki V.,Institutul Of Chimie Al Academiei Of Stiinte A Moldovei | Chetraru O.,Institutul Of Chimie Al Academiei Of Stiinte A Moldovei | Grinco M.,Institutul Of Chimie Al Academiei Of Stiinte A Moldovei | Vlad P.F.,Institutul Of Chimie Al Academiei Of Stiinte A Moldovei
Helvetica Chimica Acta | Year: 2013

An efficient one step, retro-biomimetic procedure for the synthesis of natural products having the atisane structure is described (Scheme 2), natural products which are components of medicinal plants and possess relevant biological activity. Their structures were confirmed by chemical transformations and spectral data. The starting materials were the known ent-kaur-16-en-19-oic acid (1) and ent-trachyloban-19-oic acid (2), diterpenoids readily available from the waste of sunflower. Copyright © 2013 Verlag Helvetica Chimica Acta AG, Zürich.


Grinco M.,Institutul Of Chimie Al Academiei Of Stiinte A Moldovei | Girbu V.,Institutul Of Chimie Al Academiei Of Stiinte A Moldovei | Gorincioi E.,Institutul Of Chimie Al Academiei Of Stiinte A Moldovei | Barba A.,Institutul Of Chimie Al Academiei Of Stiinte A Moldovei | And 2 more authors.
Tetrahedron Letters | Year: 2016

The first biomimetic synthesis of methyl (8S,9R,13R,14R)-4,4,8,9,13-pentamethyl-20(10 → 9)-abeo-ent-isocopal-5(10),11(12)-dien-15-oate - a diterpenoid with the ent-verrucosin A/B skeleton has been performed by electrophilic isomerization of methyl 12α-hydroxy-ent-isocopal-13(16)-en-15-oate. The structure and stereochemistry of the synthesized compound have been established on the basis of spectroscopic data. © 2016 Elsevier Ltd. All rights reserved.

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