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Monsalvo A.C.,Fundacion INFANT | Batalle J.P.,Fundacion INFANT | Lopez M.F.,Fundacion INFANT | Krause J.C.,Vanderbilt University | And 25 more authors.
Nature Medicine | Year: 2011

Pandemic influenza viruses often cause severe disease in middle-aged adults without preexisting comorbidities. The mechanism of illness associated with severe disease in this age group is not well understood. Here we find preexisting serum antibodies that cross-react with, but do not protect against, 2009 H1N1 influenza virus in middle-aged adults. Nonprotective antibody is associated with immune complex-mediated disease after infection. We detected high titers of serum antibody of low avidity for H1-2009 antigen, and low-avidity pulmonary immune complexes against the same protein, in severely ill individuals. Moreover, C4d deposition-a marker of complement activation mediated by immune complexes-was present in lung sections of fatal cases. Archived lung sections from middle-aged adults with confirmed fatal influenza 1957 H2N2 infection revealed a similar mechanism of illness. These observations provide a previously unknown biological mechanism for the unusual age distribution of severe cases during influenza pandemics. © 2011 Nature America, Inc. All rights reserved.

Lopez Linares S.,Institutos Of Salud Dr Carlos G Malbran | Martin Heer I.,Institutos Of Salud Dr Carlos G Malbran
Revista Argentina de Endocrinologia y Metabolismo | Year: 2014

Introduction: Iodine deficiency is the main cause of preventable mental deficiency and brain damage in the population. Salt iodization is required by law 17259/67 in Argentina. The aim of the study has been to determine the iodine content of salt available at retail outlets from different localities of provinces of the northwest (NOA), northeast (NEA), and Cuyo regions.

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