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O'Daly J.A.,Astralis LTD. | O'Daly J.A.,Center for Psoriasis Research and Treatment | O'Daly J.A.,Instituto Venezolano Of Investigaciones Cientificas Altos Of Pipe | Gleason J.,Astralis LTD. | And 4 more authors.
Archives of Dermatological Research | Year: 2011

A first generation vaccine (AS100-1) was manufactured with protein from four cultured Leishmania species, which proved to be effective in the treatment of psoriasis. A single blind trial on 3,132 psoriasis patients revealed 508 (16.2%) subjects with psoriatic arthritis (PsA) that received AS100-1 antigens. The study group was distributed according to percent psoriasis area and severity index (PASI) reduction from PASI 10 to PASI 100. All groups decreased in arthritis score (AS), tender joints counts and nail changes after treatment; the highest decreased in the PASI 100 group. Relapses of psoriasis and PsA had PASI and AS lower than initial values before treatment. Clinical remissions were at lower doses and less time, after the second course of treatment. Peripheral blood mononuclear cells (PBMC) lymphocyte subsets (LS) varied with PASI range (1-10, 11-20 and 21-72). Pre-treatment, absolute values of gated LS: CD4+, CD8+HLA-, CD8+HLA+, CD8+CD3-, CD8+CD3+ decreased in PBMC as PASI increased, suggesting migration from the blood to the skin. In contrary to the previous finding, the following LS: CD8+CD4-, CD3+CD8-, HLA+CD8-, CD19, CD8+CD4+ and membrane surface immunoglobulin IgA+, IgD+, IgM+, IgE+, and IgG+ increased in PBMC as PASI increased suggesting activation and proliferation by unknown antigens creating a homeostatic cycle between skin/joints and peripheral blood. After nine doses of AS100-1, the following LS: CD8+CD3+, CD8+HLA+, CD3+CD8-, CD4+CD8-, CD8+HLA-, HLA+CD8-, CD8+CD3-, CD19+, CD8+CD4-, CD8+CD4+, IgA+, IgD+, IgM+, IgE+, and IgG+ decreased significantly as compared with values before treatment. The LS decreased stops the vicious cycle between skin/joints and blood explaining clinical remission of lesions. © 2011 Springer-Verlag. Source


O'Daly J.A.,Astralis LTD. | O'Daly J.A.,Center for Psoriasis Research and Treatment | O'Daly J.A.,Instituto Venezolano Of Investigaciones Cientificas Altos Of Pipe | Rodriguez B.,Instituto Venezolano Of Investigaciones Cientificas Altos Of Pipe | And 2 more authors.
Archives of Dermatological Research | Year: 2010

Peripheral blood mononuclear cells (PBMC) collected from subjects prior to treatment and post-treatment with a vaccine composed of leishmania antigens were analyzed by flow cytometry. Upon analysis, it was noticed that lymphocyte subsets (LS) varied with psoriasis area and severity index (PASI) range (1-10, 11-20 and 21-72). Pre-treatment absolute values of gated LS were as follows. CD4+CD8-, CD3+CD8-, CD8+CD3+, CD8+CD4- and CD8+HLA- decreased in PBMC as PASI increased, suggesting migration from the blood to the skin. Contrary to the previous finding, the following LS, CD8+HLA+ and HLA+CD8-, and membrane surface immunoglobulin IgA+, IgD+ and IgM+ increased in PBMC as PASI increased, suggesting activation and proliferation by unknown antigens. After treatment with seven doses of AS100, the following LS, CD3+CD8-, CD8+CD3-, HLA+CD8-, CD8+HLA+ and CD4+CD8-, increased, while CD8+CD3+, CD8+HLA-, CD19 and CD8+CD4+ decreased in PBMC. © 2009 Springer-Verlag. Source


Avila-Cabadilla L.D.,National Autonomous University of Mexico | Stoner K.E.,National Autonomous University of Mexico | Stoner K.E.,New Mexico State University | Nassar J.M.,Instituto Venezolano Of Investigaciones Cientificas Altos Of Pipe | And 7 more authors.
PLoS ONE | Year: 2014

Tropical dry forests (TDFs) are highly endangered tropical ecosystems being replaced by a complex mosaic of patches of different successional stages, agricultural fields and pasturelands. In this context, it is urgent to understand how taxa playing critical ecosystem roles respond to habitat modification. Because Phyllostomid bats provide important ecosystem services (e.g. facilitate gene flow among plant populations and promote forest regeneration), in this study we aimed to identify potential patterns on their response to TDF transformation in sites representing four different successional stages (initial, early, intermediate and late) in three Neotropical regions: México, Venezuela and Brazil. We evaluated bat occurrence at the species, ensemble (abundance) and assemblage level (species richness and composition, guild composition). We also evaluated how bat occurrence was modulated by the marked seasonality of TDFs. In general, we found high seasonal and regional specificities in phyllostomid occurrence, driven by specificities at species and guild levels. For example, highest frugivore abundance occurred in the early stage of the moistest TDF, while highest nectarivore abundance occurred in the same stage of the driest TDF. The high regional specificity of phyllostomid responses could arise from: (1) the distinctive environmental conditions of each region, (2) the specific behavior and ecological requirements of the regional bat species, (3) the composition, structure and phenological patterns of plant assemblages in the different stages, and (4) the regional landscape composition and configuration. We conclude that, in tropical seasonal environments, it is imperative to perform long-term studies considering seasonal variations in environmental conditions and plant phenology, as well as the role of landscape attributes. This approach will allow us to identify potential patterns in bat responses to habitat modification, which constitute an invaluable tool for not only bat biodiversity conservation but also for the conservation of the key ecological processes they provide. © 2014 Avila-Cabadilla et al. Source


Del Toro R.,Instituto Venezolano Of Investigaciones Cientificas Altos Of Pipe | Del Toro R.,Central University of Venezuela | Minichini M.,Central University of Venezuela | Brito J.L.,Instituto Venezolano Of Investigaciones Cientificas Altos Of Pipe | Betancourt P.,Central University of Venezuela
Catalysis Letters | Year: 2013

Abstract: Unsupported Mo carbide and Mo nitride catalysts have been synthesized by temperature programmed synthesis, and characterized by X-ray diffraction, X-ray photoelectron spectroscopy, H2-temperature programmed reduction and desorption and N2 physisorption. These solid compounds have been tested for the hydrodechlorination (HDCl) of polychlorinated biphenyls (PCBs) at 1 bar in a fixed bed reactor. The Mo carbides and the corresponding Mo nitride phases showed a catalytic activity higher than a conventional HDS catalyst consisting of alumina-supported NiMo sulfides (~35 %). Aroclor 1260 HDCl conversion results were related to spilt-over hydrogen species that were proposed to favor the hydrogenolysis of C-Cl bond on refractory phases. The original PCBs broad distribution changed almost completely to non-chlorinated biphenyl on the carbide and nitride catalysts. Graphical Abstract: [Figure not available: see fulltext.] © 2013 Springer Science+Business Media New York. Source

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