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Muro del Alcoy, Spain

Castellano D.,Institute Investigacion Sanitaria La Fe | Blanes M.,Instituto Tecnologico Textil AITEX | Marco B.,Instituto Tecnologico Textil AITEX | Cerrada I.,Institute Investigacion Sanitaria La Fe | And 7 more authors.
Stem Cells and Development | Year: 2014

The development of biomaterials for myocardial tissue engineering requires a careful assessment of their performance with regards to functionality and biocompatibility, including the immune response. Poly(3-hydroxybutyrate) (PHB), poly(e-caprolactone) (PCL), silk, poly-lactic acid (PLA), and polyamide (PA) scaffolds were generated by electrospinning, and cell compatibility in vitro, and immune response and cardiac function in vitro and in vivo were compared with a noncrosslinked collagen membrane (Col) control material. Results showed that cell adhesion and growth of mesenchymal stem cells, cardiomyocytes, and cardiac fibroblasts in vitro was dependent on the polymer substrate, with PHB and PCL polymers permitting the greatest adhesion/growth of cells. Additionally, polymer substrates triggered unique expression profiles of anti- and pro-inflammatory cytokines in human peripheral blood mononuclear cells. Implantation of PCL, silk, PLA, and PA patches on the epicardial surface of healthy rats induced a classical foreign body reaction pattern, with encapsulation of polymer fibers and induction of the nonspecific immune response, whereas Col and PHB patches were progressively degraded. When implanted on infarcted rat heart, Col, PCL, and PHB reduced negative remodeling, but only PHB induced significant angiogenesis. Importantly, Col and PHB modified the inflammatory response to an M2 macrophage phenotype in cardiac tissue, indicating a more beneficial reparative process and remodeling. Collectively, these results identify PHB as a superior substrate for cardiac repair. © Mary Ann Liebert, Inc. Source


Espana J.M.,Polytechnic University of Valencia | Samper M.D.,Polytechnic University of Valencia | Fages E.,Instituto Tecnologico Textil AITEX | Sanchez-Nacher L.,Polytechnic University of Valencia | Balart R.,Polytechnic University of Valencia
Polymer Composites | Year: 2013

In recent years, it has been detected an increased interest in the development of materials from renewable resources. This trend has been intensified in the industrial sector where significant efforts have been made in this field in order to adapt these natural fibers to conventional industrial processes and applications. As a result, research has been done into developing new thermoplastic matrices which are compatible with this type of reinforcing fibers. This study evaluates the influence of different coupling agents based on silanes, on the mechanical properties of composite laminates made from a biobased epoxy resin matrix and basalt fabric by using vacuum assisted resin transfer moulding. The curing behavior of the biobased epoxy resin was evaluated by differential scanning calorimetry (DSC), gel point determination, and ionic conductivity. The evaluation of mechanical properties was done by tensile, flexural, impact, and hardness tests. Compatibility between basalt fibers and epoxy resin generally has managed to increase through the addition of silanes, after the addition of these, their mechanical properties are substantially improved compared to the sample without silane treatment, obtaining this way an easily processable material, with good properties and capable of competing with materials with petroleum-based epoxy resins. POLYM. COMPOS., 2013. © 2013 Society of Plastics Engineers Copyright © 2013 Society of Plastics Engineers. Source


Fages E.,Instituto Tecnologico Textil AITEX | Girones S.,Instituto Tecnologico Textil AITEX | Sanchez-Nacher L.,Polytechnic University of Valencia | Garcia-Sanoguera D.,Polytechnic University of Valencia | Balart R.,Polytechnic University of Valencia
Polymer Composites | Year: 2012

The wet-laid process with flax (base) and polypropylene (binder) fibers has been used to obtain nonwovens for further processing by hot-press molding. Mechanical characterization of nonwovens has revealed that slight anisotropy is obtained with the wet-laid process as better tensile strength is obtained in the preferential deposition direction. The thermo-bonding process provides good cohesion to nonwovens, which is critical for further handling/shaping by hot-press molding. Flax:PP composites have been processed by stacking eight individual flax:PP nonwoven sheets and applying moderate temperature and pressure. As the amount of binder fiber is relatively low (<30 wt%) if compared with similar systems processed by extrusion and injection molding, it is possible to obtain eco-friendly composites as the total content on natural fiber (flax) is higher than 70 wt%. Mechanical characterization of hot-pressed flax:PP composites has revealed high dependency of tensile and flexural strength on the total amount of binder fiber as this component is responsible for flax fiber embedment which is a critical parameter to ensure good fiber-matrix interaction. Combination of wet-laid techniques with hot-press molding processes is interesting from both technical and environmental points of view as high natural fiber content composites with balanced properties can be obtained. POLYM. COMPOS., 2012. © 2011 Society of Plastics Engineers. Source


Fages E.,Instituto Tecnologico Textil AITEX | Cano M.A.,Instituto Tecnologico Textil AITEX | Girones S.,Instituto Tecnologico Textil AITEX | Boronat T.,University of Alicante | And 2 more authors.
Textile Research Journal | Year: 2013

In this work, the wet-laid technique has been used to obtain flax nonwovens thermally bonded with different contents of polyvinyl alcohol (PVA) and bicomponent polyamide 6/copolyamide (PA6/CoPA) fibers in the 10-30 wt.% range. Scanning electron microscopy has been used to evaluate the formation of interlock points through melted polymer and flax fibers. Volume porosity has been estimated through determination of thickness and surface mass. Tensile strength and elongation at break have been determined on longitudinal (preferential) and transversal directions to evaluate anisotropy. The sound absorption properties of stacked sheets of flax: PVA and flax: PA6/CoPA nonwovens have been evaluated. In addition, the thermal insulating properties of individual nonwovens have been obtained. Mechanical characterization shows slight anisotropy. The absorption coefficient is interesting in the medium frequencies range, and relatively low thermal conductivity and thermal resistance values are obtained with these nonwovens (in the 0.020-0.025 W m-1 K-1 range for flax: PVA nonwovens and in the 0.09-0.10 W m-1 K-1 range for flax: PA6/CoPA nonwovens). By taking into account these features, these nonwoven substrates could find interesting applications as sound absorbers and/or thermal insulation materials in technical applications. © The Author(s) 2013. Source

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