Gonzalez D.,Instituto Superior Polytechnic Jose Antonio Echevarria |
Rodriguez M.,Instituto Superior Polytechnic Jose Antonio Echevarria
VacciMonitor | Year: 2013
The gangliosides are glycosphingolipids that are distributed in the organism in different forms. The presence of the ganglioside N-Glycolil GM3 (NGcGM3) has been described in human tumoral cells, that is why it has became an attractive target for the specific antitumoral therapy. This molecule is the main component of the vaccine candidate for breast cancer in clinical trials phase. Lactose acceptor is a key intermediate to obtain this ganglioside by chemical synthesis, the protection of the positions 3',4' of lactose with an isopropiliden group is necessary in the synthesis of lactose acceptors that will be used to form part of oligosaccharides and glycoconjugates. This work is focused in the reaction to obtain 3',4'-lactose-isopropiliden, an intermediate in lactose acceptor synthesis. The reaction conditions were studied and the best results were found working at +1 level of temperature and -1 level of time reaction. The reaction was made in a 5 L reactor and the results were reproducible. The thin layer semi-quantitative chromatography was chosen to quantify the amount of the isomers 3',4' and 4',6'-lactose isopropiliden obtained in the reaction.
Lopez L.F.C.,Instituto Superior Polytechnic Jose Antonio Echevarria |
Salerno D.,University of Salerno |
Dentale F.,University of Salerno |
Capobianco A.,University of Naples Federico II |
Buccino M.,University of Naples Federico II
Proceedings of the International Offshore and Polar Engineering Conference | Year: 2015
This paper discusses preliminary results of a wide experimental campaign carried out in the frame of a collaboration between the Government of the isle of Cuba and the CUGRI consortium, an Italian institution which joins the Universities of Salerno and Napoli Federico II. The tests were aimed to analyze the performances of different solutions designed to reduce the overtopping of the Malecòn, a vertical face seawall protecting the northern waterfront of the city of La Habana. The shallow foreshore in front of the structure allowed assessing the role of wave setup and low frequency components of the incoming wave spectrum on the predictions of the mean overtopping rate. Copyright © 2015 by the International Society of Offshore and Polar Engineers (ISOPE).
Socorro R.,Instituto Superior Polytechnic Jose Antonio Echevarria |
Mico L.,University of Alicante |
Oncina J.,University of Alicante
Pattern Recognition Letters | Year: 2011
This work focus on fast nearest neighbor (NN) search algorithms that can work in any metric space (not just the Euclidean distance) and where the distance computation is very time consuming. One of the most well known methods in this field is the AESA algorithm, used as baseline for performance measurement for over twenty years. The AESA works in two steps that repeats: first it searches a promising candidate to NN and computes its distance (approximation step), next it eliminates all the unsuitable NN candidates in view of the new information acquired in the previous calculation (elimination step). This work introduces the PiAESA algorithm. This algorithm improves the performance of the AESA algorithm by splitting the approximation criterion: on the first iterations, when there is not enough information to find good NN candidates, it uses a list of pivots (objects in the database) to obtain a cheap approximation of the distance function. Once a good approximation is obtained it switches to the AESA usual behavior. As the pivot list is built in preprocessing time, the run time of PiAESA is almost the same than the AESA one. In this work, we report experiments comparing with some competing methods. Our empirical results show that this new approach obtains a significant reduction of distance computations with no execution time penalty. © 2011 Elsevier B.V. All rights reserved.
Torres-Hugues R.,Instituto Superior Polytechnic Jose Antonio Echevarria |
Cordova-Lopez L.,Instituto Superior Polytechnic Jose Antonio Echevarria
Tecnologia y Ciencias del Agua | Year: 2010
Engineering structures for beach rehabilitation require a design methodology for the optimal development of projects, due to the need of solving coastal erosion problems. The Coastline and Maritime Structure Physical Modeling Group of the Hydraulic Research Center has had to pose methodologies to make beach rehabilitation projects more efficient. The development and evolution analysis of one of such methodologies is presented.
Valino E.C.,Institute Ciencia Animal |
Ibarra A.,Institute Ciencia Animal |
Garcia Y.,Institute Ciencia Animal |
Izquierdo E.,Instituto Superior Polytechnic Jose Antonio Echevarria |
Dustet J.C.,Instituto Superior Polytechnic Jose Antonio Echevarria
Cuban Journal of Agricultural Science | Year: 2011
In order to describe the sugarcane bagasse fermentation by Trichoderma viride M5-2 in a static bioreactor through a phenomenologic model, the software FERSOLID was used (Dustet 2004). The data were the yield coefficients, the reactor traits, and the type of kinetic model. As outputs of the software, it was obtained the performance of the air flow in respect to the time and the time behavior of the biomass concentration, of the substrate, and the solid humidity. The outcomes obtained in the description of the model predict a constant value or air flow throughout the fermentation time, if the air input and output temperatures are kept constant. The substrate concentration showed a performance similar to the decline observed experimentally. The final biomass was comparable to that estimated through the true protein in the experiment. The percentages of initial and final humidity, calculated by the model were almost the same, which agreed with the experimental results, where there was progressive increment of the substrate humidity. This work proved that the model can be used to evaluate the bioreactor functioning, out of the comparison between the experimental information and that predicted by the model. However, the humidity results deserve greater attention to attain the best initial fit, considering the microbial metabolism. Also, it is possible to use it in the bioreactor functioning design, always fulfilling the fundamental predictions in which the model was established.