Tschoeke D.A.,Instituto Oswaldo Cruz Fiocruz IOC |
Tschoeke D.A.,Instituto Oswaldo Cruz |
Nunes G.L.,Instituto Oswaldo Cruz |
Jardim R.,Instituto Oswaldo Cruz Fiocruz IOC |
And 23 more authors.
Evolutionary Bioinformatics | Year: 2014
Leishmaniasis is an infectious disease caused by Leishmania species. Leishmania amazonensis is a New World Leishmania species belonging to the Mexicana complex, which is able to cause all types of leishmaniasis infections. The L. amazonensis reference strain MHOM/BR/1973/M2269 was sequenced identifying 8,802 codifying sequences (CDS), most of them of hypothetical function. Comparative analysis using six Leishmania species showed a core set of 7,016 orthologs. L. amazonensis and Leishmania mexicana share the largest number of distinct orthologs, while Leishmania braziliensis presented the largest number of inparalogs. Additionally, phylogenomic analysis confirmed the taxonomic position for L. amazonensis within the “Mexicana com-plex”, reinforcing understanding of the split of New and Old World Leishmania. Potential non-homologous isofunctional enzymes (NISE) were identified between L. amazonensis and Homo sapiens that could provide new drug targets for development. © the authors, publisher and licensee Libertas Academica Limited.