Entity

Time filter

Source Type


Garcia-Repetto R.,Instituto Nacional Of Toxicologia Y Ciencias Forenses
Revista Espanola de Medicina Legal | Year: 2015

The correct interpretation of postmortem toxicology results offers an explanation on the meaning and significance of the obtained analytical results. Interpretation agreement to reality will depend on the quality of the sample and analytical results. It will also depends on the knowledge of the existence of different postmortem phenomena and the circumstances in which the death occurred. The whole process is hampered by the lack of recommendations or protocols to guide the toxicologist in the process of interpretation. Therefore, it is the more complex stage of toxicological research. In order to assist the forensic toxicologist in this task, this review of the existing knowledge on this matter is presented. © 2014 Asociación Nacional de Médicos Forenses. Source


Martinez Gonzalez M.A.,Instituto Nacional Of Toxicologia Y Ciencias Forenses
Revista Espanola de Medicina Legal | Year: 2012

Forensic toxicology requires indisputable and legally defensible analytical results. The qualitative criteria are provided by prestigious international and local organizations. This work reviews and evaluates them to gather in one document these different existing guidelines. The aim of this work is to contribute to the quality of the expertise and to implement the common scientific criteria. Both aspects are crucial in forensic toxicology to achieve toxicological results based on solid scientific foundations. The criteria, to be taken into consideration, for a correct detection and identification are discussed. The strategies for detection and the requirements for validation of these methodologies are detailed. The importance of mass spectrometry, as the most reliable technique for identification, is recognized. The criteria for analytical techniques and for toxics are also detailed. Moreover, this review and compendium of criteria try to serve those professionals who need to evaluate the toxicological findings submitted by the forensic laboratories. © 2011 Asociación Nacional de Meacute;dicos Forenses. Source


Martinez Gonzalez M.A.,Instituto Nacional Of Toxicologia Y Ciencias Forenses
Revista Espanola de Medicina Legal | Year: 2014

Forensic toxicology requires indisputable and legally defensible analytical results. Reliable analytical results are essential for the accurate interpretation of toxicological findings. Analytical criteria in forensic toxicology - based on the regulations and recommendations - are provided by prestigious international and local organizations, and their fulfilment is essential to achieve toxicological results based on solid scientific foundations. This work is a continuation of the review and assessment of analytical criteria in forensic toxicology, started with the recently published work in this journal «Qualitative criteria in forensic toxicology». It is aimed at contributing to the quality of the expert witness report and implementing common scientific criteria, both crucial aspects in forensic toxicology. The criteria necessary for an accurate quantification are reviewed, assessed and compiled in this work, detailing the requirements to validate methodologies. Moreover, this work is intended to serve those professionals who need to assess toxicological findings submitted by forensic laboratories. © 2013 Asociacion Nacional de Medicos Forenses. Publicado por Elsevier Espana, S.L. Todos losderechos reservados. Source


Barrio-Caballero P.A.,Instituto Nacional Of Toxicologia Y Ciencias Forenses
Revista Espanola de Medicina Legal | Year: 2013

In the human identification field, Forensic Genetics serves an outstanding role every time. However, there are circumstances where its task could be obstructed. This is the case of human dried bones discovery. The taphonomic conditions of this finding could imply a limitation on adequate quantity and quality of obtaining DNA for bone identification. In these cases, special and different strategies to the usual ones must be executed on forensic laboratories. In the present revision, firstly, the adequacy of using bone fragments to obtain DNA is assessed. This extracted DNA will be employed on subsequent identification genetic studies. Secondly, preservation problems of DNA obtained from this type of samples will be presented. Likewise, methodological complications to obtain this DNA will be set out. In particular, the co-extraction with PCR inhibitors will be considered, although degradation and molecular modification of DNA must not be forgotten. Finally, principal DNA extraction protocols of bone fragments will be evaluated. The protocols, which are designed to eliminate those PCR inhibitors, will be especially considered. © 2012 Asociacón Nacional de Médicos Forenses. Published by Elsevier España, S.L. All rights reserved. Source


Suarez-Mier M.P.,Instituto Nacional Of Toxicologia Y Ciencias Forenses | Merino J.L.,Hospital Universitario La Paz
Cardiovascular Pathology | Year: 2013

A 38-year-old woman without significant cardiovascular risk factors was admitted in the coronary care unit with the diagnosis of acute coronary syndrome without ST-segment elevation. In coronary angiography, left coronary artery system was normal in the first contrast injection, but acute occlusion of the left main coronary trunk (LCT) due to iatrogenic dissection was observed in the following. The patient presented marked ST elevation, severe hypotension, hemodynamic collapse, and loss of consciousness. Cardiopulmonary resuscitation (CPR) was initiated, and two drug-eluting stents were consecutively placed in the LCT and the left anterior descending coronary (LAD), but the patient died after 60 min of continuous CPR. The autopsy showed dissection of the LCT and LAD coronaries with both stents placed in the false lumen and hyperacute myocardial infarction in the anterior left ventricular free wall. This case underlines the importance of careful indication of invasive procedures and of taking in consideration their potential risks. © 2013 Elsevier Inc. Source

Discover hidden collaborations