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Loureiro I.,New University of Lisbon | Miranda N.,Instituto Nacional Of Saude Doutor Ricardo Jorge | Pereira Miguel J.M.,Institute Of Med Preventiva Da Faculdade Of Med Of Lisbon E Institute Nac Of Saude Doutor Ricardo Jorge
Revista Portuguesa de Saude Publica | Year: 2013

Health, a fundamental human right, is critical to human development. Traditionally it has been regarded as being mainly the responsibility of ministries of health. A better understanding of health determinants has showed that policies and actions of other social sectors are among the factors that most influence population's health. The movement of healthy cities is based in the concepts of co-production and responsibility for health. The municipalities integrating the Portuguese Network of Healthy Cities are committed to intentional planning to promote health, based in policies addressed to physical and cultural environment and to the educational process of communities, promoting participation, empowerment and equity. To promote the recognition of health impact of political decisions taken at different sectors and different levels - national, local - as well as health as a support for resilience against adversity, the project Capacity Building in Health Promotion [Projeto de Capacitação em Promoção da Saúde] - PROCAPS was decided by the National Institute of Health Dr. Ricardo Jorge, in collaboration with the Escola Nacional de Saúde Pública from the New University of Lisbon. This project started by studying the actual perception of the political members of municipalities about their role in health promotion and stimulating their responsibility in promoting the health of the populations. In this paper some results of the study and related actions taken are presented. Local policies and actions are proposed as well as processes of action-research and community based participatory research. © 2012 Escola Nacional de Saúde Pública. Published by Elsevier España, S.L. All rights reserved.

Coelho A.,Instituto Nacional Of Saude Doutor Ricardo Jorge | Dias A.,Hospital Prof Doutor Fernando Fonseca | Morais A.,Hospital de Santa Maria | Nunes B.,INSA | And 4 more authors.
European Journal of Haematology | Year: 2014

Chronic haemolysis stands out as one of the hallmarks of sickle cell anaemia, a clinically heterogeneous autosomal recessive monogenic anaemia. However, the genetic architecture of this sub-phenotype is still poorly understood. Here, we report the results of an association study between haemolysis biomarkers (serum LDH, total bilirubin and reticulocyte count) and the inheritance of 41 genetic variants of ten candidate genes in a series of 99 paediatric SS patients (median current age of 9.9 yr) followed up in two general hospitals in Greater Lisboa area (median follow-up per patient of 5.0 yr). Although in a large number of tests a seemingly significant (i.e. P < 0.05) association was observed, the following ones were confirmed upon correction for multiple comparisons: (i) an increased serum LDH level was associated with haplotype 7 within VCAM1 gene; (ii) a lower total bilirubin was associated with the 3.7-kb deletion at HBA gene, rs2070744_T allele at NOS3 gene, and haplotype 9 within VCAM1 promoter; and (iii) a diminished reticulocyte count was associated with the 3.7-kb deletion at HBA, whereas an increased count was associated with rs1984112_G allele at CD36 gene. On the whole, our findings suggest a complex genetic architecture for the sickle cell anaemia haemolysis process involving multiple pathways, namely control of vascular cell adhesion, NO synthesis and erythrocyte volume and haemoglobinisation. © 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

D'Antuono F.,Campus Universitario Of Science Degli Alimenti | Sanches-Silva A.,Instituto Nacional Of Saude Doutor Ricardo Jorge | Costa H.S.,Instituto Nacional Of Saude Doutor Ricardo Jorge
Nutrition Bulletin | Year: 2010

The Sustainable exploitation of bioactive components from the Black Sea Area traditional foods (BaSeFood) is a 3-year collaborative research programme, funded by the 7th Framework Programme, launched on the 1st of April 2009. The project, which is coordinated by Dr Filippo D'Antuono (University of Bologna), consists of a research consortium of 13 partners, namely Italy (two), the United Kingdom, Greece, Portugal, Serbia and six Black Sea area countries: Russian Federation, Ukraine (two), Romania, Bulgaria, Turkey and Georgia. BaSeFood will contribute scientifically by studying the bioactive compounds within traditional foods of the Black Sea area using rigorous analytical and biological assays. The vast array of characteristics of traditional foods will be considered, as well as any associated consumer-perceived benefits, related to health claims, so that they can be properly understood by the consumer and exploited by food processors to produce more healthy traditional foods. © 2010 The Authors. Journal compilation © 2010 British Nutrition Foundation.

Dias M.G.,Instituto Nacional Of Saude Doutor Ricardo Jorge | Camoes M.F.,University of Lisbon | Oliveira L.,Instituto Nacional Of Saude Doutor Ricardo Jorge
Accreditation and Quality Assurance | Year: 2012

For consistent interpretation of an analytical method result it is necessary to evaluate the confidence that can be placed in it, in the form of a measurement uncertainty estimate. The Guide to the expression of Uncertainty in Measurement issued by ISO establishes rules for evaluating and expressing uncertainty. Carotenoid determination in food is a complex analytical process involving several mass transfer steps (extraction, evaporation, saponification, etc.), making difficult the application of these guidelines. The ISO guide was interpreted for analytical chemistry by EURACHEM, which includes the possibility of using intra- and interlaboratory information. Measurement uncertainty was estimated based on laboratory validation data, including precision and method performance studies, and also, based on laboratory participation in proficiency tests. These methods of uncertainty estimation were applied to analytical results of different food matrices of fruits and vegetables. Measurement uncertainty of food carotenoid determination was 10-30% of the composition value in the great majority of cases. Higher values were found for measurements near instrumental quantification limits (e. g. 75% for β-cryptoxanthin, and 99% for lutein, in pear) or when sample chromatograms presented interferences with the analyte peak (e. g. 44% for α-carotene in orange). Lower relative expanded measurement uncertainty values (3-13%) were obtained for food matrices/analytes not requiring the saponification step. Based on these results, the saponification step should be avoided if food carotenoids are not present in the ester form. Food carotenoid content should be expressed taking into account the measurement uncertainty; therefore the maximum number of significant figures of a result should be 2. © 2012 Springer-Verlag.

Pinheiro A.C.,New University of Lisbon | Viegas C.,Polytechnic Institute of Lisbon | Viegas S.,Polytechnic Institute of Lisbon | Verissimo C.,Instituto Nacional Of Saude Doutor Ricardo Jorge | And 2 more authors.
Journal of Toxicology and Environmental Health - Part A: Current Issues | Year: 2012

Indoor air quality recently entered legislation in Portugal. Several parameters must be evaluated and kept within limits in order to obtain a certification for air quality and energy consumption. Certification parameters were analyzed in two Portuguese archives in order to assess indoor air quality both for people attending or working on these premises and for maintenance of a written heritage that must be retained for future generations. Carbon monoxide (CO) and carbon dioxide (CO2), formaldehyde, and fungal counts were kept within stipulated limits. Relative humidity (RH), volatile organic compounds (VOC), particulate matter (PM10), and ozone (O3) showed values above legislated levels and justified the implementation of corrective measures. In terms of conservation, studies on the limit values are still needed, but according to the available international guidelines, some of the analyzed parameters such as PM10, O3, and RH were also above desirable values. Corrective measures were proposed to these institutions. Although this study was only of a short duration, it proved valuable in assessing potential eventual problems and constitutes the first Portuguese indoor air quality assessment taking into consideration both aspects of an archive such as human health and heritage safekeeping. © 2012 Copyright Taylor and Francis Group, LLC.

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