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Becerra J.G.F.,Valle de Mexico University | Perrusquia N.L.,Valle de Mexico University | Ruiz M.A.D.,Valle de Mexico University | Perrusquia A.L.,Instituto Nacional Of Rehabilitacion Inr | Suarez J.V.C.,Metropolitan Autonomous University
Materials Research Society Symposium Proceedings | Year: 2015

This work studies the change microstructural and mechanical properties of an ankle prosthetic material 3 16LVM stainless steel, retired from a 36 year old patient. The medical grade 31 6LVM stainless steel was characterized by scanning electron microscopy (SEM), optical microscopy (OM), X-ray diffraction (XRD), hardness Rockwell C (HRC) and nanoindentation tests. The results showed that the ankle prosthesis has different microstructural change along the implant and presence of corrosion pits with inclusions, the mechanical properties like modulus elasticity and hardness decrease. © 2015 Materials Research Society. Source


Munoz-Aviles J.,Instituto Nacional Of Rehabilitacion Inr | Penaloza-Lopez Y.R.,Torre Of Investigacion Del Instituto Nacional Of Rehabilitacion | Flores-Avalos B.G.,Medicina de Electrodiagnostico | Flores-Rodriguez T.B.,Medicina de Electrodiagnostico | Herrera-Rangel A.B.,National Autonomous University of Mexico
Revista Mexicana de Neurociencia | Year: 2011

Introduction: In a previous study, prolongation of P300 wave latencies was observed in women with low education. Objective: To prove that there are not differences in amplitude and latency of mismatch negativity (MMN) and P300 between two groups of elderly adults (aged ≥ 60 years) of both genders with continued intellectual activity and high level of education. Methods: Two groups of elderly adults were allocated into 2 groups with years of education >15 years. Continued intellectual activity, Wechsler IQ test, mini-mental state examination, clock test and Yesavage scale were evaluated, all with normal results. Normal auditory brainstem responses (ABR). Without risk factors for central auditory processing disorders. ABR, MMN and P300 were measured for both groups: 6-lead (3 central, 3 frontal) latency and amplitude records (p < 0.05). Results: A total of 37 elderly adults were studied: group I (GI, n = 28) with 60-69 years of age (mean 64 ± 2.7 years); group II (GII, n = 9) 3 70 years (mean 77 ± 3.7 years). Years of formal education in GI:21 ± 4 years; GII: 20 ± 5 years. In MMN and P300 significant differences were observed between both groups for P300 FZ latency. Conclusion: The results of this study suggest that a high level of education and continued intellectual activity in elderly adults influence performance favorably, a finding evidenced by the absence of electrophysiological changes previously described in other elderly adults. Source


Objective: to analyze the postoperative changes in patients undergoing lumbar discectomy, both in patients whose evolution has been satisfactory, as in those with "Failed lumbar Surgery Syndrome", emphasizing the fair value that the nuclear magnetic resonance has. Methods: the work environment consists of two groups: Group I, five patients with satisfactory evolution and asymptomatic. Group II is composed of ten patients with unsatisfactory results and/or Failed Lumbar Syndrome. The results obtained in the nuclear magnetic resonance image were analyzed, emitting a diagnosis with external evaluation without knowledge of the clinical status of patients, and a correlation with clinical status in both groups was performed. Results: the clinical preoperative manifestations had a very similar distribution. Transoperatory complications were not reported in any of the two groups. In all the groups, the histopathology study was carried out and it was reported the disk degenerated or hyalinization. In Group I, it was not found any abnormality, despite its clinical state. In all the patients, postoperative fibrosis data was found in four cases, and residual disk root was compressed in five patients. In Group II, only in eight patients, the nuclear magnetic resonance showed abnormal findings. The abnormal findings were: fibrosis postoperative in five cases (50%), residual disk in three cases (30%), and data root compression in six cases (60%). Conclusion: there is no congruence between the nuclear magnetic resonance and clinic findings, in postoperative patients, of lumbar disectomy with a satisfactory development, who, so far, are asymptomatic. The nuclear magnetic resonance is not reliable in these patients. Source


Hernandez-Zamora E.,Instituto Nacional Of Rehabilitacion Inr | Zavala-Hernandez C.,Laboratorio Central Of Patologia Clinica | Quintana-Gonzalez S.,Instituto Mexicano del Seguro Social IMSS | Reyes-Maldonado E.,National Polytechnic Institute of Mexico
Cirugia y Cirujanos | Year: 2015

Background: Von Willebrand disease is the most common inherited disorder of the coagulationproteins in humans. There are three types: 1, 2A, 2B, 2N, 2M and 3. It is associated withmutations on chromosome 12 in the region p13.2, encoding the von Willebrand factor (VWF),which is synthesized in endothelial cells and megakaryocytes.Discussion: The VWF gene has been characterised using molecular biology techniques, whichhave acquired an important role in diagnosis von Willebrand disease, as well as in the investiga-tion of alterations in other genes, which may be involved in regulating the synthesis, processing,and secretion of VWF. However, there are still no strategies to integrate the molecular biologydiagnostic tests available.Analysis of VWF multimers is a methodology that meets the characteristics for diagnosis,but it is not easy to standardise. Considering that even in tertiary centres in our country,von Willebrand patients do not have a definitive diagnosis, it is necessary to implement thesemethodologies to study and improve diagnosis.Conclusions: Von Willebrand disease is highly heterogeneous due to the molecular mechanismsthat produce the various clinical and laboratory phenotypes. In Mexico there are few studiesrelated to this disease; therefore it is essential to conduct a comprehensive study including clini-cal, basic, and special testing laboratory tests, in order to establish a correct diagnosis, developnew therapeutic approaches, and offer the appropriate medical care and genetic counselling. © 2015 Academia Mexicana de Cirugia A.C. Publicado por Masson Doyma México S.A. Source


Leyva-Gomez G.,Instituto Nacional Of Rehabilitacion Inr | Cortes H.,Instituto Nacional Of Rehabilitacion Inr | Magana J.J.,Instituto Nacional Of Rehabilitacion Inr | Leyva-Garcia N.,Instituto Nacional Of Rehabilitacion Inr | And 2 more authors.
Drug Discovery Today | Year: 2015

The absence of a definitive treatment for Parkinson's disease has driven the emerging investigation in the search for novel therapeutic alternatives. At present, the formulation of different drugs on nanoparticles has represented several advantages over conventional treatments. This type of multifunctional carrier, owing to its size and composition, has different interactions in biological systems that can lead to a decrease in ability to cross the blood-brain barrier. Therefore, this review focuses on the latest advances in obtaining nanoparticles for Parkinson's disease and provides an overview of technical aspects in the design of brain drug delivery of nanoparticles and an analysis of surface phenomena, a key aspect in the development of functional nanoparticles for Parkinson's disease. © 2015 Elsevier Ltd. Source

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