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Leiden and Cambridge factor V coagulation mutations and activated protein C resistance (RaPC) are alterations related with vein and artery thrombosis. In this study we aimed to determine whether RaPC is associated with the presence of Leiden and Cambridge mutation and the frequency of these mutations in the racially mestizo Mexican population. We included 150 Mexican patients with primary thrombophilia and 100 healthy subjects in this study. RaPC was determined using commercial methods and genotypes FV Leiden and FV Cambridge with PCR-RFLPs. RaPC was positive in four patients and in one control individual; however, there was no presence of Leiden or Cambridge mutation in the studied group; thus, RaPC was not correlated with the presence of any of the studied mutations. These results indicate that there are other primary or secondary causes different from those studied, which condition the presence of RaPC. Furthermore, the frequency obtained for RaPC in our thrombophilic population of racially mixed Mexicans is lower compared to that obtained in the Caucasian population, most probably because they are genetically different populations.

Moreno-Lozano M.,Instituto Nacional Of Rehabilitacion
Spinal Cord | Year: 2016

Objectives:No studies have reported sexual dysfunction in Mexican women with a spinal cord injury (SCI).The objective of the present study was to determine the association between sociodemographic factors and sexual dysfunction characteristics in Mexican females with SCI.Methods:An observational, cross-sectional, descriptive study was conducted in different rehabilitation centers in Mexico City from July 2013 to November 2014. Adult females with a SCI without any gynecologic structural abnormalities, which by itself produced sexual dysfunction, were included. The Female Sexual Function Index (FSFI) was answered personally by all participants. Other variables such as AIS (American spinal injury association Impairment Scale), neurologic level, time since injury, age, relationship status, socioeconomic status, spasticity, use of antispasticity drugs, education level, antidepressant medication, Spinal Cord Independence Measure III score, offspring, work activities and neuropathic pain were considered.Results:There is a high percentage of sexual dysfunction among Mexican woman with SCI (81.9%). Age range went from 18- to 78-year old (42.8±15.87-year old). Time since injury went from 2 to 708 months (65.16±117.65 months). The study showed a negative correlation between age and the FSFI questionnaire (correlation coefficient (CC)=−0.384, P<0.001).There was no significant difference between the means (analysis of variance) of the different groups for neurologic level, socioeconomic status, spasticity and education level.Conclusion:Results showed that the younger the person is, the better sexual function they have, and offspring decreased sexual function and work activities increased it. Some variables showed small comparative groups (use of antidepressives/antispastics and comorbilities), which may be the reason we could not see significative differences in the means.Spinal Cord advance online publication, 23 February 2016; doi:10.1038/sc.2016.19. © 2016 International Spinal Cord Society

Munoz-Pedroza L.A.,Asociacion Leonesa de Distrofia Muscular S.A. Leon | Arenas-Sordo M.L.,Instituto Nacional Of Rehabilitacion
Acta Otorrinolaringologica Espanola | Year: 2013

Facio-Auriculo-Vertebral (FAV) spectrum, also known as Goldenhar syndrome or first and second branchial arch syndrome, is a complex of mainly craniofacial and vertebral anomalies. Microtia is a principal malformation in this complex; it can be unilateral or bilateral.We performed an observational, retrospective, transverse descriptive clinical study, reviewing 149 records of patients with a diagnosis of microtia treated in the Genetics Department.There was no significant difference in the sex of the individuals involved. The mean age was 6.97 years, with a range of 1 to 52 years. We founded positive inbreeding in 14 patients and consanguinity in 1 case. There was a family history of microtia in 37 cases. The most frequent malformations, besides microtia, were facial, costo-vertebral, limb, cardiac, genital, eye and other defects.Patients had a high percentage of family history, which could suggest an autosomal dominant inheritance with reduced penetrance. © 2013 Elsevier España, S.L.

Ruiz-Suarez M.,Instituto Nacional Of Rehabilitacion | Aziz-Jacobo J.,Plano Orthopedic Sports Medicine and Spine Center | Barber F.A.,Plano Orthopedic Sports Medicine and Spine Center
Arthroscopy - Journal of Arthroscopic and Related Surgery | Year: 2010

Purpose: To determine the resistance to cyclic stress and load-to-failure strength of several suture anchors suitable for hip arthroscopy. Methods: Ten polyetheretherketone (PEEK) PushLock, PEEK SutureTak, and Bio-SutureTak anchors (Arthrex, Naples, FL); Lupine Loop BR anchors (DePuy Mitek, Norwood, MA); Bio-Mini Revo anchors (ConMed Linvatec, Largo, FL); and BioRaptor 2.9 AB anchors (Smith & Nephew, Andover, MA) were inserted in rotation into different locations on the rim of 4 matched pairs of potted acetabula clamped to the base of a servohydraulic testing machine. The anchors' sutures were cyclically pulled in line with the insertion angle. Displacement at 100 and 500 cycles, yield load, ultimate failure load, and failure mode were recorded. Statistical analysis was performed. Results: Most of the displacement observed during cyclic loading occurred in the first 100 cycles, except for the BioRaptor 2.9 AB, which showed twice as much displacement at 500 cycles as at 100 cycles. The Lupine Loop BR cyclic displacement was greater than that of the PEEK PushLock (at 100 cycles also), Bio-SutureTak, and PEEK SutureTak at 500 cycles (P < .05). The BioRaptor 2.9 AB cyclic displacement was significantly greater at 100 and 500 cycles than that of the PEEK PushLock and Bio-SutureTak (P < .05). The mean ultimate failure loads for these anchors ranged from 154 N (PEEK SutureTak) to 255 N (Bio-Mini Revo) and was statistically equivalent (P = .139). Correlation analysis showed no significant associations between anchor stiffness, cyclic load displacement, or failure load. Conclusions: Anchors with specific indications for hip arthroscopy showed very little displacement and had consistent failure loads under cyclic conditions in the acetabular rim. All hip anchors except the BioRaptor 2.9 AB showed less than 2.0 mm of displacement after 500 cycles. Clinical Relevance: Biomechanical testing of suture anchors designated for hip arthroscopy should be performed in the acetabular rim before their use. Suture anchors used for shoulder arthroscopy may not perform as well in the hip. © 2010 Arthroscopy Association of North America.

Non-surgical treatment of Achilles tendinopathies ad plantar fasciitis has shown good results in up to 90% of cases. However, the remaining 10% of patients with these conditions represent a true challenge for the orthopedic surgeon. New technologies for the development of orthobiologic materials make it possible to use platelet-rich plasma (PRP) as an alternative to treat cases that have been refractory to prior treatment and that have a chronicity exceeding 12 months. Prospective, analytical study. Patients with diagnosis of Achilles tendinopathy, plantar fasciitis or both, with a course of more than 12 months, previously treated with non-surgical alternatives, without any clinical improvement. The AOFAS hindfoot scale was used, together with the Visual Analog Scale (VAS) for pain, and photographic documentation at 2, 4, 8 and 12 months after infiltration. A treatment program that included immobilization, NSAIDs, eccentric exercises for the Achilles-calcaneal-plantar system and strengthening of the sural triceps was established. The statistical analysis included measurements of the central trend and scatter with the SPSS 15. A sample consisting of 10 patients (12 feet) that met the diagnostic and inclusion criteria was obtained. Mean age at the time of presentation was 43 years (range 23-56), with females being predominant (70%) and 50% laterality for the right and left feet. The initial AOFAS score was 39 (range 28-68) and the VAS score was 9 (range 7-10). By week 16 the AOFAS score had increased to 97 (range 88-99) and the VAS score was 2 (range 1-4). All patients resumed independent gait. The use of PRP in patients with Achilles tendinopathy and plantar fasciitis is an effective and safe alternative for the management of patients with a poor response to conventional non-surgical treatment. Other non-surgical modalities are recommended besides PRP for the treatment of these patients to achieve appropriate results.

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